Abstract: Provided are engineered cells with enhanced transcriptional activities of a transcriptional enhanced associate domain (TEAD) protein, and methods of making and use thereof. The engineered cells overexpress a TEAD coactivator (e.g., a YAP peptide or a WWTR1 peptide).

Abstract: Disclosed is a dual chimeric antigen receptor (Dual-CAR) system targeting neuroendocrine lineage markers, comprising (1) a first CAR comprising a primary intracellular signaling domain of an immune cell and (2) a second CAR that does not comprise a primary intracellular signaling domain derived from CD3? or a primary intracellular signaling domain of an immune cell. Relates to a single CAR system targeting a neuroendocrine lineage marker. Also described are engineered immune cells comprising such systems and the use of these cells in the treatment of cancer.

Abstract: Obtain, using at least one hardware processor, data characterizing a physical system governed by a physical conservation law. Apply, using the at least one hardware processor, contrastive learning to the data to automatically capture system invariants of the physical system. Employ, using the at least one hardware processor, a neural projection layer to guarantee that a corresponding dynamic machine learning model preserves the captured system invariants. Optionally, predict performance of the physical system using the corresponding dynamic machine learning model.

Abstract: A current sampling circuit for a multi-level DC-DC converter having first and second power switches connected in series, and a first inductor having one terminal coupled to a common node of the first and second power switches, where the current sampling circuit is configured to: receive a first signal representing a current flowing through the first power switch; receive a second signal representing a current flowing through the second power switch; and generate a third signal representing an inductor current flowing through the first inductor according to the first signal and the second signal.

Abstract: One or more computer processors create a fully convolution network (FCN) comprising a plurality of 1×1 convolutions. The one or more computer processors append linear mapping layer (LM) to created FCN. The one or more computer processors capture a plurality of features utilizing multi-scale dilated convolutional kernels from the linear mapped FCN (LM-FCN). The one or more computer processors apply an average pool layer to the captured plurality of features along a temporal axis of a dilated convolutional kernel within the LM-FCN. The one or more computer processors predict a classification for subsequent time-series data utilizing the pooled plurality of features.

Abstract: A track lamp includes a track having a power transmission bar, and an electrical connection device in electrical contact with the track. The electrical connection device includes a substrate, a power supply structure plugged and fixed on the substrate, and an elastic member arranged between the substrate and the power supply structure. The power supply structure features a convex portion in electrical contact with the power transmission bar. The elastic member is configured to bias the convex portion and the power transmission bar against each other, such that the convex portion and the power transmission bar are kept in contact with each other.

Abstract: A track light belongs to the field of lighting technology is provided. The track light includes a track, and a lamp in electrical contact with the track, the lamp includes a substrate, an elastic structure, and a power obtain structure plugged and fixed on the substrate, the substrate is provided with a through hole, the elastic structure includes a mounting post and an elastic portion, the mounting post is accommodated in the through hole and is in contact with an inner wall of the through hole, a power transmission strip is provided in the track, the power obtain structure includes an abutment portion in electrical contact with the power transmission strip, the elastic portion is provided between the abutment portion and the substrate to generate elastic deformation in response to that the abutment portion and the power transmission strip are pressed against each other.

Abstract: A temperature-strain detection system and method for reservoir rock mass are disclosed by the present disclosure, which relate to the field of rock engineering geomechanics testing and measurement. The temperature-strain detection system and method for reservoir rock mass includes a light source, a strain measurement module, a temperature measurement module, a sensing optical fiber, and a processing module. The light source is respectively connected to the strain measurement module and the temperature measurement module; the strain measurement module and the temperature measurement module are both connected to the processing module; the strain measurement module and the temperature measurement module are both connected to the sensing optical fiber; the sensing optical fiber is arranged in the reservoir rock mass; the sensing optical fiber is engraved with an uwFBG array.

Abstract: Disclosed are a telescopic pulse ash blower capable of blowing ash at multiple angles and an ash blowing method. The telescopic pulse ash blower includes a fixed inner core tube, a traveling device, a multipoint rotating mechanism, an outer nozzle tube, a combined propelling device, a base, and a nozzle. The combined propelling device is mounted at one end of the base. The fixed inner core tube is arranged above the combined propelling device. The outer nozzle tube is sleeved on an outer side of the fixed inner core tube. The outer nozzle tube is connected to the traveling device. The traveling device is connected to the combined propelling device. The multipoint rotating mechanism is arranged on an outer side of the outer nozzle tube, the nozzle is connected to the outer nozzle tube. A gas mixer inlet is formed at a top of the fixed inner core tube.

Abstract: Provided is a system for engineering geomechanical experimental testing of a reservoir rock mass, including a stress control unit, a temperature control unit and a rock sample holder. The stress control unit includes a rigid pressure-applying mechanism and a flexible pressure-applying mechanism. The rigid pressure-applying mechanism is configured to apply rigid pressure to a rock mass via an indenter and a pressing piece. The flexible pressure-applying mechanism is configured to apply flexible pressure to the rock mass by using a pressure medium. Rigid pressure application and flexible pressure application are integrated to simulate a stress status under an actual geological condition better, and uniformity of pressure application is also ensured. The temperature control unit is configured to control a temperature of the rock mass via a heating mechanism and a cooling mechanism. A method for engineering geomechanical experimental testing of a reservoir rock mass is further provided.

Abstract: The present application provides GPC2-specific antibodies and antigen binding fragments thereof. A chimeric antigen receptor (CAR) that specifically binds glypican-2 (GPC2) comprising a GPC2-specific antibody, a transmembrane domain, and an intracellular signaling domain. T cells comprising the disclosed CAR constructs can be used for cancer immunotherapy.

Abstract: A track light, including a track, a lamp and latch structures connecting the track and the lamp. Each latch structure comprises a latch member, a connection member, a gasket and a locking member. The lamp is provided with mounting portions and mounting holes penetrating through the mounting portions. The connection members penetrate through the mounting holes and extend out of the lower surfaces of the mounting portions. The locking members are inserted from bottom to top into the connection members and are locked to be fixed to the tail ends of the connection members. The gaskets are sleeved on the outer side of the tail ends of connection members and are pressed to be fixed between the lower surfaces of the mounting portions and the locking members. The connection members are configured to penetrate through the mounting holes and then extend out of the lower surfaces of the mounting portions.

Abstract: Provided herein are anti-DLL3 chimeric antigen receptors (CARs), DLL3 binding proteins and uses of such CARs or DLL3 binding proteins in the treatment of DLL3 associated disorders, such as small cell lung cancer.

Abstract: This application discloses an electrode plate rolling apparatus and an electrode plate rolling method that are configured to roll an electrode plate. The electrode plate includes a coated region and an uncoated region. The electrode plate rolling apparatus includes a roller group, a heating part, and a cooling part. The heating part is configured to heat the electrode plate, and the cooling part is configured to cool the electrode plate. The heating part further includes an extension assembly, and the extension assembly can extend the uncoated region when the heating part heats the electrode plate. The electrode plate passes through the cooling part after passing through the heating part. The heating part and the cooling part are configured to reduce a difference between an extensibility parameter of the uncoated region and an extensibility parameter of the coated region.

Abstract: A current sampling circuit for a multi-level DC-DC converter having first and second power switches connected in series, and a first inductor having one terminal coupled to a common node of the first and second power switches, where the current sampling circuit is configured to: receive a first signal representing a current flowing through the first power switch; receive a second signal representing a current flowing through the second power switch; and generate a third signal representing an inductor current flowing through the first inductor according to the first signal and the second signal.

Abstract: A computer implemented method for certifying robustness of image classification in a neural network is provided. The method includes initializing a neural network model. The neural network model includes a problem space and a decision boundary. A processor receives a data set of images, image labels, and a perturbation schedule. Images are drawn from the data set in the problem space. A distance from the decision boundary is determined for the images in the problem space. A re-weighting value is applied to the images. A modified perturbation magnitude is applied to the images. A total loss function for the images in the problem space is determined using the re-weighting value. A confidence level of the classification of the images in the data set is evaluated for certifiable robustness.

Abstract: The present disclosure provides a water-soluble 1,3-diphenylguanidine (DPG)-based supramolecular inclusion complex and a preparation method and use thereof. A supramolecular compound and a vulcanization accelerator DPG are subjected to supramolecular interaction to form a DPG-based supramolecular inclusion complex. While improving water solubility and dispersibility of the DPG, a molecular structure of the DPG can be completely retained, and the supramolecular host used does not affect a performance of latex. The supramolecular compound and the DPG are ball milled in a certain proportion to prepare the DPG-based supramolecular inclusion complex, the water-soluble DPG-based supramolecular inclusion complex is added in a natural latex curing process; and after mixing evenly, a mixture is foamed on-machine, vulcanized in a steamer, and dried to obtain a latex foam product.

Abstract: A shear box for testing shear-seepage coupling characteristics of rock mass, and a method of using the shear box are provided, including an upper fixed shear box, and a lower movable shear box. A first extrusion block and an upper rock mass sample are arranged in a first placement groove of the upper fixed shear box. A second extrusion block and a lower rock mass sample are arranged in a second placement groove of the lower fixed shear box. A first elastic sealing member is arranged on each of both sides of the upper rock mass sample and the lower rock mass sample, and an elastic capsule is arranged on each of inner walls of both sides of the first placement groove and the second placement groove. An upper pressure head device for applying a force in a third direction is arranged on the upper fixed shear box.

Abstract: Provided is a sample fixture for an indirect tensile test of rock mass, relating to the technical field of rock mass engineering geomechanics tests. The sample fixture includes an upper fixture, and a lower fixture located below the upper fixture. The upper fixture includes an upper fixing block, a ball head, and an upper knife. The lower fixture includes a lower fixing block, a telescopic positioning plate, and a lower knife. The ball head is in fit with a spherical groove on an upper surface of the upper fixing block to achieve the function of transferring pressure, thus ensuring loading strength acting on a sample. A loading force is transferred by using a cutting edge of the upper knife to make the pressure act on the sample intensively, thus ensuring point or linear loading required by the test.

Abstract: There is provided a solution for advantage generation. In the solution, a value model is pretrained based on respective returns for respective first tokens in a first response of a plurality of first responses output by a trained reference model. A return for a first token indicates a cumulative reward from the first token to an end of the first response. Respective advantages for respective second tokens in a second response of a plurality of second responses output by a language model are generated based on the pretrained value model. An advantage for a second token indicates a cumulative reward for the second token relative to an average of cumulative rewards for candidate tokens at a position of the second token.