Abstract: The present application provides anti-LAG-3 constructs comprising a single-domain antibody (sdAb) that specifically recognizes LAG-3. Also provided are methods of making and using these constructs.

Abstract: A computer implemented method for certifying robustness of image classification in a neural network is provided. The method includes initializing a neural network model. The neural network model includes a problem space and a decision boundary. A processor receives a data set of images, image labels, and a perturbation schedule. Images are drawn from the data set in the problem space. A distance from the decision boundary is determined for the images in the problem space. A re-weighting value is applied to the images. A modified perturbation magnitude is applied to the images. A total loss function for the images in the problem space is determined using the re-weighting value. A confidence level of the classification of the images in the data set is evaluated for certifiable robustness.

Abstract: The present invention belongs to the field of environment monitoring, particularly relates to a CO2 storage state networking monitoring device, system and method with multi-information fusion. The present invention comprises: obtaining orientation electrical signal data and real-time pressure signals, analyzing a fluid flowing state at a view of a pressure sensor through the real-time pressure signals, and obtaining a CO2 flowing state through the orientation electrical signal data; and obtaining a CO2 regional storage state by combining an orientation CO2 content, a CO2 flowing state and the fluid flowing condition at the view of the pressure sensor. By combining accurate short-range CO2 boundary monitoring of orientation electrodes with long-range monitoring of pressure sensors to achieve a wide range of CO2 flowing state monitoring, the present invention can observe more data with higher reliability and effectively aims at the problem of strong inter-well heterogeneity.

Abstract: Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.

Abstract: A polypeptide comprising a chimeric antigen receptor (CAR) comprising (i) an extracellular domain capable of binding to a first antigen, (ii) a transmembrane domain, and (iii) an intracellular domain; and a domain capable of binding to a second antigen expressed on the surface of a cell that can interact with a T cell, wherein the CAR and the domain are fused by a peptide linker.

Abstract: A graph neural network (GNN)-based prediction system for total organic carbon (TOC) in shale solves the problem that the existing shale TOC prediction method cannot fully analyze the complex nonlinear relationship between all logging curves and TOC. The prediction system adopts a method including: acquiring and preprocessing a plurality of logging curves of a target well location in a target shale bed to acquire a plurality of standardized logging curves, windowing the plurality of standardized logging curves, and inputting the windowed logging curves and weight matrix into a trained GNN-based TOC prediction network to acquire TOC of the target well location. The prediction system inputs the plurality of logging curves as correlative multi-dimensional dynamic graph data for analysis and can acquire the complex nonlinear relationship between the logging curves and TOC, thus improving the prediction accuracy of TOC.

Abstract: The disclosure discloses a garage mode control unit, system and method capable of preventing vehicle miss-acceleration in narrow site. The control method comprises the steps that vehicle environment information is received; whether a vehicle is in the narrow site or not is judged according to the vehicle environment information; and the vehicle is controlled according to a garage mode when the condition that the vehicle is in the narrow site is judged.

Abstract: The invention belongs to the field of environmental monitoring, and in particular relates to a method for optimally selecting a carbon storage site based on multi-frequency band seismic data.

Abstract: This application discloses an electrode plate rolling apparatus and an electrode plate rolling method that are configured to roll an electrode plate. The electrode plate includes a coated region and an uncoated region. The electrode plate rolling apparatus includes a roller group, a heating part, and a cooling part. The heating part is configured to heat the electrode plate, and the cooling part is configured to cool the electrode plate. The heating part further includes an extension assembly, and the extension assembly can extend the uncoated region when the heating part heats the electrode plate. The electrode plate passes through the cooling part after passing through the heating part. The heating part and the cooling part are configured to reduce a difference between an extensibility parameter of the uncoated region and an extensibility parameter of the coated region.

Abstract: An organic electroluminescent display panel, a method of manufacturing the same, and a display device that can alleviate or avoid the occurrence of pixel crosstalk problems due to lateral conduction of the charge generation layer are disclosed. An organic electroluminescent display panel is provided which comprises: a substrate; an anode layer and a pixel defining layer over the substrate, the pixel defining layer defining pixel units, wherein a recess is provided in the pixel defining layer between adjacent pixel units; a stack of organic electroluminescent units over the anode layer and the pixel defining layer, the stack comprising at least two organic electroluminescent units and a charge generation layer disposed between organic electroluminescent units which are adjacent to each other; a cathode layer over the stack. The corresponding charge generation layers of the adjacent pixel units are disconnected at the recesses. The cathode layer is continuous at the recess.

Abstract: A power converter can include: positive and negative input terminals configured to receive an input voltage; positive and negative output terminals configured to generate an output voltage; first and second power switches sequentially coupled in series between the positive input terminal and a first node; third and fourth power switches sequentially coupled in series between a second node and the negative input terminal, where there is no physical connection between the first node and the second node; a first energy storage element coupled between a common terminal of the first and second power switches and a common terminal of the third and fourth power switches; a first multi-level power conversion circuit coupled between the first node and the positive output terminal; and a second multi-level power conversion circuit coupled between the first node and the positive output terminal.

Abstract: The present disclosure provides a multi-scale three-dimensional (3D) engineering geological model construction system and method. A regional geological model of a target region, a site geological model of each engineering site, and a drilling geological model of each drilling well are constructed. The geological model of each drilling well is superimposed to the site geological model of the corresponding engineering site in the way of step-by-step superimposition, and the site geological model of each engineering site fused with the drilling geological model is superimposed to the regional geological model of the target region. Thus, multi-scale geological model fusion of drilling well, engineering site, and regional mountain is realized.

Abstract: A power converter can include: N switching power stage circuits, where output terminals of the N switching power stage circuits are connected in parallel, and N is a positive integer; an energy storage element coupled between an input terminal and the output terminal of the power converter, where the energy storage element is configured to periodically store energy for delivery to the output terminal of the power converter; and where after a main transistor of an M-th switching power stage circuit is turned off, a main transistor of the (M+1)-th switching power stage circuit is turned on, in order to realize zero-voltage-switching (ZVS) of the main transistor of (M+1)-th switching power stage circuit, where M is a positive integer less than N.

Abstract: An integrated driver applied to a voltage converter having a switched capacitor conversion circuit, the integrated driver including: a first die having a first-type power transistor; a second die including at least one second-type power transistor, where a withstand voltage of the first-type power transistor is higher than a withstand voltage of the second-type power transistor; and where the first die and the second die are coupled in series between a high potential terminal and a low potential terminal of the voltage converter, such that the first-type power transistor receives a high voltage signal.

Abstract: A power converter can include at least one first power stage circuit and a second power stage circuit, where each of the at least one first power stage circuit can include: at least one power switch, configured as a main power switch; a first magnetic element; a first energy storage element configured to be coupled to a first node of the first power stage circuit together with one adjacent power stage circuit, and to be charged or discharged through the adjacent power stage circuit; and an auxiliary module configured to ensure that a current flowing through the first magnetic element is not less than zero in a current discontinuous mode, where a first terminal of the second power stage circuit is coupled to an adjacent first power stage circuit.

Abstract: A current sampling circuit for a multi-level DC-DC converter having first and second power switches connected in series, and a first inductor having one terminal coupled to a common node of the first and second power switches, where the current sampling circuit is configured to: receive a first signal representing a current flowing through the first power switch; receive a second signal representing a current flowing through the second power switch; and generate a third signal representing an inductor current flowing through the first inductor according to the first signal and the second signal.

Abstract: This application discloses an electrode plate rolling apparatus and an electrode plate rolling method that are configured to roll an electrode plate. The electrode plate includes a coated region and an uncoated region. The electrode plate rolling apparatus includes a roller group, a heating part, and a cooling part. The heating part is configured to heat the electrode plate, and the cooling part is configured to cool the electrode plate. The heating part further includes an extension assembly, and the extension assembly can extend the uncoated region when the heating part heats the electrode plate. The electrode plate passes through the cooling part after passing through the heating part. The heating part and the cooling part are configured to reduce a difference between an extensibility parameter of the uncoated region and an extensibility parameter of the coated region.

Abstract: The present disclosure relates to an organic electroluminescent display panel, a method of manufacturing the same, and a display device that can alleviate or avoid the occurrence of pixel crosstalk problems due to lateral conduction of the charge generation layer.

Abstract: A method of controlling a three-level DC-DC converter having first, second, third, and fourth power switches coupled in series between an input voltage and a reference ground, and a flying capacitor coupled between a common node of the first and second power switches and a common node of the third and fourth power switches, can include: operating the flying capacitor in a first mode in which the voltage across the flying capacitor is controlled to not be decreased in at least two consecutive first intervals, where each first interval is half of a switching period of the three-level DC-DC converter; and operating the flying capacitor in a second mode in which the voltage across the flying capacitor is controlled not to be increased in at least two consecutive first intervals, such that the voltage across the flying capacitor approaches a predetermined value.

Abstract: The present disclosure belongs to the field of capture, utilization, and storage of carbon dioxide, particularly relates to a method and system for intelligently identifying a carbon storage box based on a GAN network, and aims at solving the problem that the analysis accuracy of a fault zone area in the prior art is insufficient. The method comprises the steps: delineating seismic waveform data of a stable sedimentary area through a GAN network, and removing seismic waveform data points in the fault zone area; obtaining a stable sedimentary background seismic waveform data invertomer; obtaining a three-dimensional wave impedance prediction data volume; making a difference to obtain an abnormal wave impedance data volume; retaining abnormal wave impedance data of fault-karst in the three-dimensional variance attribute volume to obtain a fault-karst wave impedance data volume; and then obtaining a carbon storage box interpretation model.