Abstract: The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula I: The invention also provides methods for treating allergic and inflammatory diseases. More particularly, the present invention relates to formulations of olopatadine and their use for treating and/or preventing allergic or inflammatory disorders of the eye, nose, skin, and ear.

Abstract: The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens.

Abstract: A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).

Abstract: The present invention relates to development of efficacious pharmaceutical compositions comprising an active agent, such as the free base or hydrochloride salt of tandospirone, for topical delivery to the eye for the treatment of retinal disorders.

Abstract: A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).

Abstract: The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens.

Abstract: An air sampler module is provided for use with a detection device that monitors liquids and/or solids on a surface using spectroscopy techniques. The air sampler module comprises a housing, an intake port for collecting air containing airborne threats to be analyzed by the detection device, and a port to permit communication of an optical transceiver of the detection device into the housing to permit analysis of the collected air. Thus, the capabilities of a spectroscopy detection system are expanded to include the ability to analyze airborne threats.

Abstract: The use of certain synthetic phospholipids to preserve pharmaceutical compositions from microbial contamination is described. The synthetic phospholipids have unique molecular arrangements wherein a phosphate group is linked to a quaternary ammonium functionality via a substituted-propenyl group, and the quaternary ammonium functionality is further linked to at least one long hydrocarbon chain. Such molecular arrangements are what make the phospholipids of formula (I) highly water soluble, e.g., the length of the hydrocarbon chain assists to maintain solubility and efficacy of the molecules for the uses described herein. The synthetic phospholipids described herein have been found to be particularly useful as antimicrobial preservatives for ophthalmic, otic and nasal pharmaceutical compositions, especially ophthalmic compositions. These compounds may also be utilized to disinfect contact lenses.

Abstract: The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent.

Abstract: Packaging materials substantially lacking adsorptive and absorptive properties for 2-pyrrolidone derivatives are provided. The packaged products described herein provide for retention of the 2-pyrrolidone derivative within the formulation thereby maintaining the integrity of such formulations. Packaged products are useful for ophthalmic, otic, and nasal applications. Ophthalmic application includes therapeutic uses and contact lens care uses.

Abstract: The present teachings provide control systems and methods for monitoring the performance of an absorption refrigerator. The system includes a temperature sensor that senses the temperature of a generator of a cooling arrangement. The circuit may communicate with the sensor and turn off a heat source of the cooling unit if a sensed temperature condition of the generator exceeds a predetermined temperature condition.

Abstract: An air sampler module is provided for use with a detection device that monitors liquids and/or solids on a surface using spectroscopy techniques. The air sampler module comprises a housing, an intake port for collecting air containing airborne threats to be analyzed by the detection device, and a port to permit communication of an optical transceiver of the detection device into the housing to permit analysis of the collected air. Thus, the capabilities of a spectroscopy detection system are expanded to include the ability to analyze airborne threats.

Abstract: The present invention provides control systems and methods for a cooling unit. The system includes a temperature sensor that senses the temperature of a cooling fin and a circuit. The circuit may communicate with a signal from the cooling unit that indicates when cooling is required. The circuit also communicates with the sensor and turns off the heat source of the cooling unit if the temperature does not decrease within a pre-selected time after cooling becomes required. Additionally, the circuit may turn off the heat source only if the temperature is above a pre-selected temperature. Moreover, a pre-selected time after turning off the heat source, the circuit may turn the heat source on.

Abstract: The present invention provides control systems and methods for a cooling unit. The system includes a temperature sensor that senses the temperature of a cooling fin and a circuit. The circuit may communicate with a signal from the cooling unit that indicates when cooling is required. The circuit also communicates with the sensor and turns off the heat source of the cooling unit if the temperature does not decrease within a pre-selected time after cooling becomes required. Additionally, the circuit may turn off the heat source only if the temperature is above a pre-selected temperature. Moreover, a pre-selected time after turning off the heat source, the circuit may turn the heat source on.

Abstract: HETE salts, the preparation of HETE salts, the preparation of stable and efficacious HETE compositions, HETE compositions and methods of use for treating dry eye are disclosed.

Abstract: A stand for carrying a reel around which a linear product such as wire may be wound. The stand comprises a base and a support member for engaging the reel in a manner that permits the reel to rotate so that the linear product may be unwound therefrom or wound thereon. The stand comprises a line guide having a guide head designed to guide the linear product during the winding or unwinding process. The guide head is carried on a guide arm which is configured to be mounted on the stand. Optionally, the line guide and stand are configured to provide a position on the stand where the line guide may be stowed when not in use. Preferably, the guide arm is flexible to permit the desired positioning of the guide head and, optionally, to facilitate stowage.

Abstract: Compositions containing one or more HETE derivative(s) and an effective concentration of ethanol and methods of use for treating dry eye are disclosed.

Abstract: The present invention is a communication system for communicatinginformation over greater distances than otherwise possible on bidirectional media subject tointerference, by reducing the interference while assuring spectral compatibility with other communication services. The system of the present invention provides symmetric data service to end users by using asymmetric signaling. In one embodiment, the present invention utilizes partially overlapped, non-symmetric baud rates and spectrally shaped transceiver filters to achieve both spectral compatibility and extended range.

Abstract: The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.

Abstract: The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.