Abstract: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof. These compounds inhibit the growth of piconaviruses, such as rhinoviruses, Hepatitus viruses, cardioviruses, polioviruses, enteroviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus.

Abstract: Certain vinyl acetylene benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus.

Abstract: The present application provides a series of benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.

Abstract: Ribosylated 2-amino-1,3,4-thiadiazoles having antiviral activity, methods of use and pharmaceutical formulations therefor.

Abstract: Compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, and R.sup.2 is cyano or --C(.dbd.S)--NH--R.sup.3 ; orR.sup.1 and R.sup.2 taken together are .dbd.C(NH.sub.2).sub.2 or .dbd.C(R.sup.5)(NHR.sup.3 ');R.sup.3 and R.sup.3 ' are hydrogen or --COOR.sup.4 ;R.sup.4 is C.sub.1 -C.sub.10 alkyl, substituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, substituted C.sub.2 -C.sub.10 alkenyl, phenyl, or substituted phenyl; andR.sup.5 is hydrogen or --S--R.sup.6 where R.sup.6 is C.sub.1 -C.sub.4 alkyl, cyano-C.sub.1 -C.sub.4 alkyl or pyridyl-C.sub.1 -C.sub.4 alkyl, and salts thereof, are useful antiviral agents.

Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.

Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.

Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.

Abstract: This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.

Abstract: Compounds of the formula ##STR1## in which Y is hydrogen or hydroxyl, useful as intermediates in the production of antibiotics, are prepared by reacting a sulfinic acid of the formula ##STR2## with an oxidizing agent.

Abstract: 7.beta.-Acylamino-3-azido-3-cephem-4-carboxylic acid esters are obtained with the corresponding 3-halo or 3-sulfonyloxy-3-cephem esters and an alkali metal azide. The 3-azido compounds as the free acids or salts are antibacterial agents while in esterified form react with alcohols and phenols to provide 2-alkoxy (or 2-phenoxy)-3amino-3-cephem esters and isomeric ring expanded 4,7-bicyclo .beta.-lactam compounds, namely [2R-(2.alpha.,7.alpha.,8.beta.)-4-alkoxy (or 4-phenoxy)-9-oxo-8-acylamino-6-thia-1,3-diazabicyclo[5.2.0]non-3-ene-2-car boxylic acids and esters and the corresponding 3-alkoxy (or 3-phenoxy) 1,4-diazabicyclo[5.2.0]non-3-ene-2-carboxylic acids and esters. These reaction products obtained with the azide possess antibacterial properties.

Abstract: 4-Fluoroazetidinone antibacterial agents are provided by a process comprising the reaction of an azetidinone-4-sulfinic acid, or a salt thereof, with perchloryl fluoride (FClO.sub.3) at -80.degree. C. to -25.degree. C., e.g., p-nitrobenzyl 3-methyl-2-(2-oxo-4-sulfino-3-phenoxyacetamido-1-azetidinyl-3-butenoate is reacted with FClO.sub.3 to provide corresponding 4-fluoroazetidinone. The latter is isomerized with a tertiary amine to corresponding 2-butenoate which a carboxy group deprotection provides an antibacterial compound.

Abstract: Certain N-substituted benzimidazoles are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and a method of treating viral infections are provided.

Abstract: Process for 4-halo azetidinones of the formula ##STR1## wherein R.sub.1 is acylamino or diacylamino, X is chloro, bromo or iodo, and R is a carboxy-protecting group which comprises treating a 4-sulfinoazetidinone of the formula ##STR2## with positive halogen reagent, eg. N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, hypohalite. The 4-haloazetidinones are useful intermediate for .beta.-lactam antibiotics.

Abstract: Novel oxazolinoazetidinone compounds are prepared by the reaction of chloroazetidinones with lead difluoride in dimethyl sulfoxide.

Abstract: Novel oxazolinoazetidinone intermediates are prepared by cyclizing 2-chloroazetidinones with lead difluoride in dimethyl sulfoxide. The oxazolinoazetidinone products are useful as intermediates in the preparation of oxygen analogues of penicillins.

Abstract: Imino chlorides of 6-aminopenicillanic esters and 7-aminocephalosporanic esters are reacted at a temperature between -80.degree. and -25.degree. C. with a strong base such as an alkali metal amide of a secondary amine and the generated anion is halogenated to provide the corresponding 6- or 7-halo-N(.alpha.-haloalkylidene) or N(.alpha.-halo-.alpha.-arylmethylidene)-6-aminopenicillanic or 7-aminocephalosporanic esters, respectively. The 6-halopenicillins and 7-halocephalosporins are converted to 6-methoxypenicillins and 7-methoxycephalosporins.

Abstract: 6-APA, 7-ACA and 7-ADCA esters are reacted with benzaldehyde, acetophenone or substituted derivatives thereof providing imines which react in the presence of a strong base such as sodium hydride or lithium diisopropyl amide with a C.sub.2 -C.sub.5 alkanoyl halide, 2,2,2-trichloroethoxycarbonyl chloride, a benzoyl halide, a C.sub.1 -C.sub.4 alkoxycarbonyl chloride or a methoxymethyl halide to afford C.sub.6 and C.sub.7 substituted .beta.-lactam imines via acylation or methoxymethylation. The .beta.-lactam substituted imines are reacted with a carbonyl reagent, e.g. Girard's reagent T to provide a C.sub.6 substituted 6-APA ester or a C.sub.7 substituted 7-ACA or 7-ADCA ester which is acylated to provide a 6-acylamido-6-substituted penicillin or a 7-acyl-amide-7-substituted cephalosporin.

Abstract: 7-Acylamido-3-alkylsulfonyloxy (and phenyl or substituted phenylsulfonyloxy)-3-cephem-4-carboxylic acids and esters thereof are provided via sulfonation of 3-hydroxy-3-cephem esters. The 3-cephem-3-sulfonate esters are useful antibacterial compounds.

Abstract: 6-Acylamino-6-alkylthiopenicillanic or 7-acylamino-7-alkylthiocephalosporanic acids or esters are reacted at a temperature between -80.degree. and -25.degree.C. with one equivalent of halogen to provide an intermediate halosulfonium halide which is reacted with a C.sub.1 -C.sub.4 alkyl amine, a C.sub.1 -C.sub.4 dialkylamine or ammonia in an appropriate solvent. The ester group is removed to provide the 6-aminopenicillanic or 7-aminocephalosporanic acid.