Patents by Inventor Wayne A. Spitzer

Wayne A. Spitzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids
    Patent number: 3954731
    Abstract: 6-Acylamido-6-lower alkylthio (benzylthio) penicillanic and 7-acylamido-7-lower alkylthio (benzylthio)cephalosporanic and deacetoxycephalosporanic acid esters are reacted at a temperature between -80.degree. and -25.degree.C. with one equivalent of halogen to provide an intermediate halosulfonium halide which is reacted with a C.sub.1 -C.sub.4 lower alcohol, benzyl alcohol, p-nitrobenzyl alcohol or 2,2,2-trichloroethanol in the presence of a hydrogen halide acceptor to provide the corresponding 6- or 7- O-alkyl, benzyl, p-nitrobenzyl or 2,2,2-trichloroethyl penicillanic, cephalosporanic or deacetoxycephalosporanic acid esters. The 6- and 7- (2,2,2-trichloroethoxy) substituted penicillin or cephalosporin is reacted with zinc in formic acid to provide the 6- or 7-hydroxypenicillin or cephalosporin respectively.
    Type: Grant
    Filed: October 4, 1973
    Date of Patent: May 4, 1976
    Assignee: Eli Lilly and Company
    Inventor: Wayne A. Spitzer