Patents by Inventor Wayne E. Childers

Wayne E. Childers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functionalized N,N-dialkylamino phenyl ethers and their method of use
    Patent number: 11873267
    Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: January 16, 2024
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Magid A. Abou-Gharbia, Wayne E. Childers, Marlene A. Jacobson, Rong Fan, Rogelio L. Martinez
  • Aminothiazole compounds and methods using same
    Patent number: 11787794
    Abstract: The present invention includes novel aminothiazole compounds of formula (I), which are useful in preventing or treating cancer in a subject in need thereof.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: October 17, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • (S)-2-AMINO-6-((3-AMINOPROPYL)AMINO)HEXANOIC ACID (APL) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH), LIVER INFLAMMATION, HEPATOCELLULAR BALLOONING, LIVER FIBROSIS AND STEATOSIS
    Publication number: 20230172886
    Abstract: (S)-2-amino-6-((3-aminopropyl)amino)hexanoic acid (APL) for use in the treatment of non-alcoholic steatohepatitis (NASH), liver inflammation, hepatocellular ballooning, liver fibrosis and steatosis.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 8, 2023
    Inventors: Salim MERALI, Wayne E. CHILDERS, Carlos BARRERO, George C. MORTON, Mario Cesar RICO
  • Compositions and methods for treatment of insulin resistance
    Patent number: 11596615
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: March 7, 2023
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Functionalized N,N-dialkylamino phenyl ethers and their method of use
    Patent number: 11325883
    Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 10, 2022
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Edward G. Melenski, Wayne E. Childers, Marlene A. Jacobson, Magid A. Abou-Gharbia
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20210052532
    Abstract: In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of A1C, glucose, insulin, homeostasis model of assessment of insulin resistance HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof.
    Type: Application
    Filed: March 7, 2019
    Publication date: February 25, 2021
    Applicant: Temple University - Of The Commonwealth System Of Higher Education
    Inventors: Salim MERALI, Carlos A. BARRERO, Wayne E. CHILDERS, George C. MORTON
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20210046030
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: July 17, 2020
    Publication date: February 18, 2021
    Inventors: Salim Merali, Carlos A. Barrero, Wayne e. Childers, George c. Morton
  • NOVEL FUNCTIONALIZED N,N-DIALKYLAMINO PHENYL ETHERS AND THEIR METHOD OF USE
    Publication number: 20200392073
    Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.
    Type: Application
    Filed: May 24, 2017
    Publication date: December 17, 2020
    Inventors: Magid A. Abou-Gharbia, Wayne E. Childers, Marlene A. Jacobson, Rong Fan, Rogelio L. Martinez
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20200392075
    Abstract: Compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein X is selected from the group consisting of —O—, —S—, —NR14—O—, —O—NR14—, —NR14—NR15— and —S—S—; R1-R15, m, n, o, p, q and r are as defined herein, are provided for treatment for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: March 7, 2019
    Publication date: December 17, 2020
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Novel Functionalized N,N-Dialkylamino Phenyl Ethers and Their Method of Use
    Publication number: 20200354307
    Abstract: Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.
    Type: Application
    Filed: November 20, 2018
    Publication date: November 12, 2020
    Inventors: Edward G. Melenski, Wayne E. Childers, Marlene A. Jacobson, Magid A. Abou-Gharbia
  • Beta lactams as modulators of glutamate uptake and methods for use thereof
    Patent number: 10759750
    Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: September 1, 2020
    Assignee: Temple University—Of The Commonwealth System Of Higher Education
    Inventors: Magid A. Abou-Gharbia, Benjamin E. Blass, Wayne E. Childers, Mercy Ramanjulu, George C. Morton
  • Compositions and methods for treatment of insulin resistance
    Patent number: 10729670
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: August 4, 2020
    Assignee: Temple University—Of The Commonwealth Systems Of Higher Education
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Screening Method for Identification of Neuroprotective Compounds
    Publication number: 20200166517
    Abstract: The present invention provides compositions and methods for identifying modulators of palmitoylation and uses thereof.
    Type: Application
    Filed: July 18, 2018
    Publication date: May 28, 2020
    Inventors: Gareth M. Thomas, Dale D.O. Martin, Sabrina Marion Holland, Jingwen Niu, Marlene A. Jacobson, Wayne E. Childers
  • Novel Aminothiazole Compounds and Methods Using Same
    Publication number: 20200071314
    Abstract: The present invention includes novel aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Application
    Filed: November 7, 2019
    Publication date: March 5, 2020
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abou-Gharbia, Wayne E. Childers, George C. Morton
  • Aminothiazole compounds and methods using same
    Patent number: 10513516
    Abstract: The present invention includes novel aminothiazole compounds of formula (I) useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: December 24, 2019
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abu-Gharbia, Wayne E. Childers, George C. Morton
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
    Publication number: 20190192462
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Application
    Filed: September 7, 2017
    Publication date: June 27, 2019
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Novel Beta Lactams as Modulators of Glutamate Uptake and Methods for Use Thereof
    Publication number: 20190127323
    Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in its etiology.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 2, 2019
    Inventors: Magid A. Abou-Gharbia, Benjamin E. Blass, Wayne E. Childers, Mercy Ramanjalu, George C. Morton
  • Novel Aminothiazole Compounds and Methods Using Same
    Publication number: 20180215750
    Abstract: The present invention includes novel aminothiazole compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 2, 2018
    Inventors: Jean-Pierre J. Issa, Hanghang Zhang, Magid Abu-Gharbia, Wayne E. Childers, George C. Morton
  • Beta lactams as modulators of glutamate uptake and methods for use thereof
    Patent number: 9975879
    Abstract: Pharmaceutical compositions of the invention comprise compounds, compositions, methods useful for the treatment of drug addiction, drug withdrawal, and diseases or conditions that involve dysregulation of glutamate homeostasis in it etiology.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: May 22, 2018
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Magid Abou-Gharbia, Wayne E. Childers, Rogelio L. Martinez, Mercy M. Ramanjulu, Benjamin E. Blass
  • PCSK9 Inhibitors and Methods of Use Thereof
    Publication number: 20170290806
    Abstract: The present invention relates to compositions and methods for treating lipid disorders in a subject. In one embodiment, the compositions of the present invention can be used to inhibit protease proprotein convertase subtilisin-like kexin type 9 (PCSK9). In another embodiment, the compositions of the present invention can be used to disrupt the protein-protein interaction between PCSK9 and low-density lipoprotein receptor (LDLR).
    Type: Application
    Filed: September 8, 2015
    Publication date: October 12, 2017
    Inventors: Magid Abou-Gharbia, Wayne E. Childers