Patent number: 6239134
Abstract: The present invention provides compounds of the general formula (1):
wherein:
two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen;
R is H, halogen, OH, SH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, phenoxy, thiophenoxy, phenyl or substituted phenyl;
A is C, CH, or N;
R1 is aryl, heteroaryl, or cycloalkyl groups, optionally substituted by from 1 to 3 substituents selected from C1-C6 alkyl, C1-C6 alkoxy; CF3, Cl, Br, F, CN, or CO2CH3;
R2is H or alkyl
R3 is C1-C6 alkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heteroaryl, C3 to C8 cycloalkyl optionally substituted by C1-C6 alkyl, or a 3 to 8-membered heterocyclic ring containing one or more heteroatoms selected from O, S or N; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders using these compounds.
Type:
Grant
Filed:
February 25, 2000
Date of Patent:
May 29, 2001
Assignee:
American Home Products Corp.
Inventors:
Annmarie L. Sabb, Robert L. Vogel, Michael G. Kelly, Yvette L. Palmer, Wayne E. Childers
