Patents by Inventor Wayne P. Fitzmaurice

Wayne P. Fitzmaurice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for expressing a library of nucleic acid sequence variants and selecting desired traits
    Patent number: 6468745
    Abstract: The present invention relates to a method for using viral vectors to bear populations of sequence variants and using plant hosts to select the sequences that exhibit the desired traits.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 22, 2002
    Assignee: Large Scale Biology Corporation
    Inventors: Wayne P. Fitzmaurice, John A. Lindbo, Hal S. Padgett, Gregory P. Pogue
  • Method of increasing complementarity in a heteroduplex
    Publication number: 20020146732
    Abstract: We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective amount of enzymes having strand cleavage activity, 3′ to 5′ exonuclease activity, and polymerase activity, and allowing sufficient time for the percentage of complementarity to be increased within the heteroduplex. Not all heteroduplex polynucleotides will necessarily have all mismatches resolved to complementarity. The resulting polynucleotide is optionally ligated. Several variant polynucleotides result. At sites where either of the opposite strands has templated recoding in the other strand, the resulting percent complementarity of the heteroduplex polynucleotide sequence is increased. The parent polynucleotides need not be cleaved into fragments prior to annealing heterologous strands. Therefore, no reassembly is required.
    Type: Application
    Filed: February 1, 2002
    Publication date: October 10, 2002
    Inventors: Hal S. Padgett, John A. Lindbo, Wayne P. Fitzmaurice
  • Interspecific nicotiana hybrids and their progeny
    Publication number: 20020092036
    Abstract: The present invention relates to novel interspecific Nicotiana excelsior x N. benthamiana hybrid seeds and plants and to a method of producing interspecific Nicotiana hybrids having enhanced properties for biomass and the production of recombinant proteins using a viral vector system.
    Type: Application
    Filed: January 14, 2002
    Publication date: July 11, 2002
    Inventor: Wayne P. Fitzmaurice
  • Interspecific nicotiana hybrids and their progeny
    Patent number: 6344597
    Abstract: The present invention relates to novel interspecific Nicotiana excelsior×N. benthamiana hybrid seeds and plants and to a method of producing interspecific Nicotiana hybrids having enhanced properties for biomass and the production of recombinant proteins using a viral vector system.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: February 5, 2002
    Assignee: Large Scale Biology Corporation
    Inventor: Wayne P. Fitzmaurice
  • DNA sequences encoding enzymes useful in carotenoid biosynthesis
    Patent number: 5539093
    Abstract: DNA sequences isolated from Nicotiana species (e.g., Nicotiana benthamiana and Nicotiana tabacum) have SEQ ID NOS: 1, 3, 5 and 7. The DNA sequences encode polypeptides having enzymatic activity for producing zeta-carotene. The polypeptides are referred to as phytoene desaturase.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: July 23, 1996
    Inventors: Wayne P. Fitzmaurice, Gary M. Hellmann, Laurence K. Grill, Monto H. Kumagai, Guy R. della-Cioppa