Abstract: A self-powered microelectronic semiconductor device includes low temperature interconnection and encapsulation materials to enable integration of a battery with the microelectronics package during manufacture. The package includes a partially exposed leadframe or leads of a substrate for connecting the battery. The battery includes one or more terminal connectors that can either be manufactured by the battery vendor or externally attached using spot/laser or resistance welding. The steps of connecting the battery to the package are performed after the microelectronic package assembly to ensure the battery does not experience any high temperatures from the package assembly process. Cavities are formed in an overmolded molding compound to expose the leadframe or battery pads for electronic connection. A low temperature electrically conductive bonding agent is used to create the electrical and mechanical bond of the battery tabs to the leadframe.

Abstract: An apparatus configured to provide portioned instances of a compressible material includes a channel assembly, a gas source, a cutting assembly, and a discharge assembly. The channel assembly holds a bulk instance of the material extending through upper and lower channels of a continuous channel. The gas source supplies gas to compress the bulk instance. The cutting assembly moves in relation to the channel assembly to isolate the upper and lower channels, severing upper and lower material portions of the bulk instance. The discharge assembly directs gas to impinge on a lower face of the cutting assembly to discharge the lower material portion as a portioned instance. The channel assembly may be moveable, where operation of the gas source, cutting assembly, and/or discharge assembly are based on moving the channel assembly between various positions. The gas supply may be controlled based on a determined property of the portioned instance.

Abstract: Therapies comprising administering at least one antiviral nucleoside, and the use of such therapies in the treatment of viral infections, such as infection by Eastern equine encephalitis virus, Western equine encephalitis virus, Venezuelan equine encephalitis virus, Chikungunya virus, Ross River virus, orthomyxoviridae virus, paramyxoviridae virus, RSV, influenza A virus, influenza B virus, filoviridae virus, human coronavirus, SARS-CoV-1, MERS-CoV, SARS-CoV-2, Ebola virus, or Zika virus, are disclosed herein.

Abstract: A method may include accessing digital characteristics associated with a user identifier, the digital characteristics including a task identifier assigned to the user identifier; encoding the digital characteristics into components of an input vector, the components of the input vector corresponding to inputs of a machine learning model; inputting the input vector into the machine learning model; executing the machine learning model; subsequent to the executing, accessing an output of the machine learning model, the output corresponding to a cluster identifier associated with a plurality of user identifiers with similar digital characteristics; and automatically transmitting a request to change a resource access right for the user identifier based on access rights associated with the cluster identifier.

Abstract: An environmental control system comprises a fluid flow path which has a pump and circulates liquid to a first heat exchanger in a first room and to a second heat exchanger in a second room. The fluid flow path comprises a pump. A user inputs a target temperature for the first room via a first user interface that is located in the first room, which is communicated to the control unit and a sensor located in the room communicates the temperature in the first room to the control unit. A user inputs a target temperature for the second room via a second user interface that is located in the second room, which is communicated to the control unit and a sensor located in the room communicates the temperature in the second room to the control unit. The control is physically isolated from the user interfaces and temperatures sensors.

Abstract: The present invention provides humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from CCR4-IgG1 and recognizes the same epitope. This antibody contains either an IgG4 or a stabilized IgG4 in order to improve binding efficiency and reduce in vivo Fab arm exchange. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer.

Abstract: Methods and systems described herein are directed to automatedly detecting a vehicle accident occurrence based on a generated accident suspicion. An accident detection system can retrieve a myriad of information as data relating to a driver or a vehicle of the driver. The retrieved information can be assessed to determine assignment of a suspicion of a vehicle accident occurrence. The suspicion assignment can be based on, with respect to historical insurance data, predetermined thresholds and/or machine learning for the retrieved information. The retrieved information can be verified by auxiliary data remote from the driver or the vehicle of the driver. The accident detection system can verify the suspicion by dispatching one or more notifications to the driver, and in the absence of response, determine whether the suspicion is true via the collection of information for a suspected location of the accident or from individuals associated with the driver.

Abstract: The systems and methods disclosed herein relate to querying data using artificial intelligence models. A generalized model receives an output generation request and partitions it into segments mapped to specific domains, where each domain indicates associated databases and guidelines. The segments are routed to domain-specific models trained on domain-specific data, which generate query fragments by comparing performance metrics and system resource usage metrics. The query fragments are aggregated into an overall query that satisfies guidelines across domains. The systems and methods can include a feedback loop to adjust the domain-specific models using user interactions and performance metrics to dynamically adapt to a skill level or experience of the user.

Abstract: A method and device for reducing intraocular pressure in a patient. The method may comprise administering a viscoelastic material in Schlemm's canal to open aqueous humor outflow pathways. The device is adapted to perform the method. The viscoelastic material may be configured to lower the intraocular pressure within the eye.

Abstract: Aspects of the disclosure relate to computing platforms that utilize machine learning to perform output generation based on intent identification. The computing platform may train intent orchestration models (e.g., intent identification, output generation, or communication channel) using historical data. The computing platform may data corresponding to an individual. Based on the data, the computing platform may select intent identification models, and may use them to identify an intent. Based on the intent of the individual, the computing platform may select engagement output generation models, and may use them to generate a customer engagement output. The computing platform may use a communication channel model to identify a communication channel. The computing platform may send commands directing display of the customer engagement output, which may cause a user device to display the customer engagement output using the communication channel.

Abstract: Apparatus and associated methods relate to controlling electrical power of an electrotherapeutic signal that is provided to a biological tissue engaged by an electrosurgical instrument during a medical procedure. Electrical power—a product of a voltage difference across and an electrical current conducted by the engaged biological tissue—is controlled according to a therapeutic schedule. The electrotherapeutic schedule can be reduced or terminated in response to a termination criterion being met. In some examples, the termination criterion is a current characteristic, such as, for example, a decrease in current conducted by the engaged biological tissue. In some examples, the termination criterion is a biological tissue resistance characteristic, such as, for example, an increase in the biological tissue resistance that exceeds a predetermined delta resistance value.

Abstract: A system and method for determining native cardiac output of a heart while maintaining operation of an intracardiac blood pump includes determining a current drawn by the pump motor, a blood pressure within the ascending aorta, and a change in the blood temperature based on a thermodilution technique. An intracardiac blood pump positioned in the aorta includes at least one sensor for determining a motor current and blood pressure and a thermistor for determining the change in blood temperature after a precise fluid bolus has been introduced into the vasculature. A processor receives current, pressure, and temperature measurements, and calculates a pump flow output and a total cardiac output from which the native cardiac output is calculated. The native cardiac output and other clinically relevant variables derived from the measurements inform decisions related to continued therapeutic care, including increasing or decreasing cardiac assistance provided by the intracardiac pump.

Abstract: System, method, and instrumentalities are described herein for transmitting information optically. The optical source may be configured to generate a beam. The beam may include a series of light pulses. The beam of light may be modulated. A modulator may be configured to modulate the series of light pulses in response to a data transmission signal, thereby encoding transmission data into the series of light pulses. The modulated beam of light may be received and both amplified and filtered. The filtered beam of light may be transmitted from to a detector having a photoreceiver. The photoreceiver may be configured to extract the transmission data from the filtered beam of light.

Abstract: Provided herein are techniques that facilitate interactions with and/or control of devices provided for collaborative workspaces using body area network communications. In one example, a method is provided that may include, upon a touch of a user with a collaboration device, performing, for a user device that provides a body area network for the user, a pairing exchange facilitated via the body area network for pairing the user device and the collaboration device. During the touch of the user with the collaboration device, the method may include transmitting a user token to the collaboration device via the body area network. The method may further include transmitting a pairing communication to a collaboration service in which the communication includes the user token and a pairing token for the device and, upon successful authentication of the user by the collaboration service, pairing the user device with the collaboration device.

Abstract: A method of processing workpieces in an automated mass production system includes: (a) receiving a supply carrier at a workpiece repitch station, the supply carrier including a plurality of rows of supply retainers, each supply retainer holding a respective workpiece for unloading at the repitch station; (b) advancing a plurality of processing carriers through the repitch station, each processing carrier including a row of processing retainers for receiving respective workpieces unloaded from the supply carrier; (c) operating a repitch robot at the repitch station to repitch and transfer a set of workpieces from respective supply retainers to the respective processing retainers of a respective processing carrier at the repitch station; and (d) repeating the operating step to fill each of the plurality of processing carriers advanced through the repitch station with workpieces from the supply carrier.

Abstract: A battery pack comprises a pair of physically separate battery cells share a single protection circuit module (PCM). Each further saw comprises a respective pair of electrodes, with both pairs of electrodes being connected to a single, common protection circuit board (PCB) of the PCM. The common PCM may be located in a spacing between adjacent ends of the batteries such that a widthwise dimension of the PCB has an upright orientation between the two batteries.

Abstract: A device and a method for sealing an opening in the wall of a blood vessel is provided. The device includes pushing mechanism, a shaft fixedly connected to the pushing mechanism, a seal assembly attached to the distal end of the shaft, and a pushing rod also engaging the seal assembly, the pushing mechanism moving the pushing rod from a first position to a second position.

Abstract: A computer-implemented method and system for authorizing user access to services provided by a first entity is disclosed. The method involves receiving a request to authorize a user, retrieving a plurality of user-related metrics from a database, generating a risk metric based on these metrics, and automatically determining the user's authorization based on the risk metric. The authorization decision involves a second entity assuming risk for the services provided by the first entity. The method further includes communicating the authorization decision to a graphical user interface, providing a clear indication of the user's authorized access.

Abstract: A hemostatic material and a method of treating a bleeding wound of a human or an animal include a hemostatic powder for application to the wound. The hemostatic powder comprises a first part consisting of a native chitosan base and a second part consisting of a chitosan salt, where the first and the second parts form the main component of the hemostatic powder, or at least 50% of a total weight of the hemostatic powder, and the second part forms a layer that at least partially coats the first part. The hemostatic powder may be provided in a hemostatic spray formulation that comprises a mixture of the hemostatic powder dispersed in a liquefied gas for release from a cannister onto the wound. A treatment method involves applying the hemostatic spray formulation directly to the wound. Other embodiments are also disclosed.

Abstract: Systems and methods are described for transmitting information optically. For instance, a system may include an optical source configured to generate a beam of light. The system may include at least one modulator configured to encode data on the beam of light to produce an encoded beam of light/encoded plurality of pulses. The system may include a spectrally-equalizing amplifier configured to receive the encoded beam of light/encoded plurality of pulses from the at least one modulator and both amplify and filter the encoded beam of light/encoded plurality of pulses to produce a filtered beam of light/filtered plurality of pulses, thereby spectrally equalizing a gain applied to the encoded beam of light. In some cases, the system may slice the beam of slight, to ensure a detector has impulsive detection. In some cases, the system may include a temperature controller to shift a distribution curve of wavelengths of the optical source.