Abstract: A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein A, A? and A? are independently O, C?O, etc.; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, etc.; R6, R7 and R8 are each independently H, C1-C6 alkyl, C1-C4 alkoxy(C1-C6 alkyl), etc.; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A quick connect assembly according to an example of the present disclosure includes a first member that has a mating section at a first end. A second member includes a protruding portion received against the mating section. A clip is configured to be received within an opening of the first member such that an engagement portion of the clip is received against the protruding portion.

Abstract: An HVAC system according to an example of the present disclosure includes a blower rotatable about an axis that has a first axial end and a second axial end opposite the first axial end. A hub is positioned to divide the blower into a first section for receiving a first fluid flow and a second section for receiving a second fluid flow fluidly isolated from the first fluid flow.

Abstract: An HVAC system according to an example of the present disclosure includes a blower rotatable about an axis. The blower has a first blower section and a second blower section fluidly isolated from the first blower section. An inlet assembly at an axial end of the blower includes a first compartment configured to control fluid flow through the first blower section and a second compartment configured to control fluid flow through the second blower section.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Embodiments are directed to a tug-toy tooth brush. In one example, the tug-toy tooth brush includes a structural frame that provides support for at least one sliding element. The structural frame includes channels that guide the sliding element while sliding within the structural frame. The sliding element is configured to slide from a first position to a second position within the structural frame. The sliding element includes bristles that extrude through the structural frame. The tug-toy tooth brush also includes at least one handle attached to a distal end of the sliding element, where the handle is configured for travel through the structural frame.

Abstract: A compound compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein A, A? and A? are independently O, C?O, C—R? or N—R?, where R? and R? may independently be H, amino, —NR7COR6, COR6, —CONR7R8, C1-C6 alkyl, or hydroxy(C1-C6 alkyl), and R? may be present or absent, and is present where the rules of valency permit, and where not more than one of A, A? and A? is O or C?O; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, hydroxy(C1-C6 alkyl), phenyl(C1-C6 alkyl), formyl, heteroaryl, heterocyclic, —COR6, —OCOR6, —COOR6, —NR7COR6, —CONR7R8, and —(CH2)n—W, where W is cyano, hydroxy, C3-C8 cycloalkyl, —SO2NR7R8, and —SO2—R9, where R9 is C1-C6 alkyl, C3-C8 cycloalkyl, heteroaryl, or heterocyclic; wherein each of said alkyl, cycloalkyl, heterocyclic, or heteroaryl ma

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: An apparatus and method for deploying vivid notice to a first responder, wherein the deploying event is triggered by the vehicle crash motion or by signal from the vehicle's own crash detection system, and the vivid notice is coded to the particular hazard present at the vehicle crash site and includes at least one visual notice, auditory notice, or olfactory notice, and may include a combination of any of the three notices, or all three at once.

Abstract: A vehicle HVAC system includes a first air handling module having a blower motor assembly that includes a fan that reverses direction to selectively extract airflow from a vehicle cabin into the first air handling module and communicate a conditioned airflow from the first air handling module into the vehicle cabin.

Abstract: An apparatus and method for deploying vivid notice to a first responder, wherein the deploying event is triggered by the vehicle crash motion or by signal from the vehicle's own crash detection system, and the vivid notice is coded to the particular hazard present at the vehicle crash site and includes at least one visual notice, auditory notice, or olfactory notice, and may include a combination of any of the three notices, or all three at once.

Abstract: One embodiment of a rat/mouse trap, reconfigured to increase efficiency of take down rates, utilizing two inline and opposing alloy bows (10) mounted on an elongated wooden platform or the main body (20). Mounting holes (18) one in each of the four corners, pre-drilled for ease of horizontal or vertical mounting. The opposing and inline bows (10) are rectangular in shape, comprised of sturdy alloy; two hold down rods (14), also comprised of a suitable alloy; two adjacent bait pedals (12), comprised of a material sturdy enough to hold rod in place and two tension springs (28), all of which are either adjacent or opposing. The trap is armed by pulling the bow (10) into the locking position with one hand and holding the bow (10) in place with the thumb while extending the hold down rod (14) over the bow (10) and placing the free angled end under the bait pedal (12) engagement surface, toward centerline (32) on the main body (20). This action is repeated on the opposite side.

Abstract: The present invention generally relates to an apparatus and process for automatically cutting a textile web with reduced wrinkling.

Abstract: A tool for compressing a run flat device is provided. The tool contains a spool and a belt. The belt is wrapped around spool and the run flat device, and when the spool rotates, an effective length of the belt decreases to compress the run flat device.