Patents by Inventor Wei-Cheng Lu

Wei-Cheng Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12163168
    Abstract: Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-?-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: December 10, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Everett Stone, Wei-Cheng Lu, Christos Karamitros
  • Publication number: 20240309346
    Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: February 11, 2022
    Publication date: September 19, 2024
    Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Tia Marie DiTommaso, Anthony James Garrity
  • Patent number: 12036269
    Abstract: Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-?-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: July 16, 2024
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Wei-Cheng Lu
  • Publication number: 20240141388
    Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: March 9, 2022
    Publication date: May 2, 2024
    Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Lauren E. Alfonse, Anthony James Garrity
  • Patent number: 11946045
    Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: April 2, 2024
    Assignee: Arbor Biotechnologies, Inc.
    Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Lauren E. Alfonse, Anthony James Garrity
  • Patent number: 11866746
    Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: January 9, 2024
    Assignee: ARBOR BIOTECHNOLOGIES, INC.
    Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Tia Marie Ditommaso, Anthony James Garrity
  • Publication number: 20230295589
    Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: December 30, 2022
    Publication date: September 21, 2023
    Inventors: Shaorong CHONG, Wei-Cheng LU, Brendan Jay HILBERT, Quinton Norman WESSELLS, Tia Marie DITOMMASO, Anthony James GARRITY
  • Publication number: 20230287403
    Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: December 30, 2022
    Publication date: September 14, 2023
    Inventors: Shaorong CHONG, Wei-Cheng LU, Brendan Jay HILBERT, Quinton Norman WESSELLS, Lauren E. ALFONSE, Anthony James GARRITY
  • Publication number: 20220275099
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: October 11, 2021
    Publication date: September 1, 2022
    Inventors: George GEORGIOU, Everett STONE, Nicholas MARSHALL, John BLAZECK, Wei-Cheng LU
  • Publication number: 20210386838
    Abstract: Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-?-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.
    Type: Application
    Filed: May 25, 2021
    Publication date: December 16, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: George GEORGIOU, Everett STONE, Wei-Cheng LU
  • Publication number: 20210380962
    Abstract: Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine-?-lyases comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 9, 2021
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Everett STONE, Wei-Cheng LU, Christos KARAMITROS
  • Patent number: 11168142
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: November 9, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Nicholas Marshall, John Blazeck, Wei-Cheng Lu
  • Patent number: 11033612
    Abstract: Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-?-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: June 15, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Wei-Cheng Lu
  • Patent number: 10890839
    Abstract: The structured light imaging device includes a projector including a diffractive optical element, an image sensor, and a processing circuit. The processing circuit is configured to control the projector to emit a beam having a special pattern, and alter an amplitude of the beam during a sensing period. The image sensor is configured to capture an image corresponding to the beam during the sensing period, and transmits the image to the processing circuit. The processing circuit calculates a depth according to the image and a predetermined image having the special pattern. Therefore, the interference phenomenon is reduced.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: January 12, 2021
    Assignee: HIMAX TECHNOLOGIES LIMITED
    Inventors: Ching-Wen Wang, Cheng-Che Tsai, Tsai-Hsing Chen, Seng-Yu Huang, Wei-Cheng Lu, Hsueh-Tsung Lu
  • Patent number: 10724026
    Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: July 28, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Wei-Cheng Lu
  • Publication number: 20190390187
    Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: February 1, 2019
    Publication date: December 26, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: George Georgiou, Everett Stone, Wei-Cheng Lu
  • Patent number: 10233438
    Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: March 19, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Wei-Cheng Lu
  • Publication number: 20190002579
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: April 25, 2018
    Publication date: January 3, 2019
    Inventors: George GEORGIOU, Everett STONE, Nicholas MARSHALL, John BLAZECK, Wei-Cheng LU
  • Publication number: 20180326025
    Abstract: Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-?-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.
    Type: Application
    Filed: May 11, 2018
    Publication date: November 15, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: George GEORGIOU, Everett STONE, Wei-Cheng LU
  • Patent number: 9975959
    Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 22, 2018
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: George Georgiou, Everett Stone, Nicholas Marshall, John Blazeck, Wei-Cheng Lu