Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Abstract: Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.

Abstract: The disclosure provides an ultrasound image registration apparatus and a method thereof suitable for registering two ultrasound images partially overlapped with each other. The apparatus comprises: a first-stage image-developing processing module, a second-stage image-developing processing module and a registration module. The first-stage image-developing processing module performs beam-forming processing on two ultrasound images so as to generate two raw images. The second-stage image-developing processing module connects the first-stage module for performing envelope detection processing and compression processing on the raw images so as to generate two developed ultrasound images.

Abstract: A hardware phase shift correction method for a multi-channel apparatus is provided. The method includes the following steps. A multi-channel apparatus including a plurality of analog circuits is provided, wherein the multi-channel apparatus transmits an analog signal and receives an echo signal. In a receiving path test mode, a plurality of first test signals are received. The first test signals are enabled to pass through a receiving path of the multi-channel apparatus, and converted to a plurality of test data. In response to the test data corresponding to the first test signals, phase shift correction for the channels is performed.

Abstract: The disclosure provides an ultrasound image registration apparatus and a method thereof suitable for registering two ultrasound images partially overlapped with each other. The apparatus comprises: a first-stage image-developing processing module, a second-stage image-developing processing module and a registration module. The first-stage image-developing processing module performs beam-forming processing on two ultrasound images so as to generate two raw images. The second-stage image-developing processing module connects the first-stage module for performing envelope detection processing and compression processing on the raw images so as to generate two developed ultrasound images.