Abstract: A tool for replacing a bushing and seal of an inlet ball valve disc pivot and a method thereof, relating to the technical field of installation and maintenance of hydropower station equipment. The tool for replacing the bushing and seal of the inlet ball valve disc pivot comprises a support frame, a driving ring, a support shaft, a first support assembly and a second support assembly; the support frame includes a first ring, a second ring provided in parallel, and a plurality of connecting rods connected between the first ring and the second ring; the first ring is used for connecting to the ball valve body; the driving ring is provided between the first ring and the second ring in an adjustable position; the driving ring is used for detachable connection with the bushing; the support shaft is used for coaxial connection with the pivot.

Abstract: Provided herein is a method and device for partitioning a fluidic sample. The device contains a plate containing microwells. The method comprises depositing a sample on one or both of the plates when the plates are in an open configuration, wherein the deposition is in the form of a single or multiple droplet of the sample, wherein at least one of the droplets has a volume that occupies more than two microwells and closing the plates to the closed configuration to partition the sample in the microwells.

Abstract: The present disclosure relates to systems and methods for immune therapy. For example, a method can be used to enhance the proliferation of chimeric antigen receptor (CAR) T cells in a subject, The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising one or more lymphocyte activation agents and one or more recombinant viral particles comprising a polynucleotide encoding a CAR, wherein the proliferation of CAR T cells in the subject is greater than in a subject administered with the one or more recombinant viral particles but without the lymphocyte activation agent.

Abstract: Provided is a low-odor, high-stability ergothioneine crystal, which belongs to the field of compound crystals The powder X-ray diffraction pattern of the ergothioneine crystal, measured using Cu-K? radiation and expressed in terms of 2?, has characteristic peaks at least at 9.50±0.2°, 15.52±0.2°, 19.06±0.2°, 24.88±0.2°, 25.48±0.2°, 28.74±0.2°, 29.22±0.2°, and 35.10±0.2°. The new crystal form of ergothioneine has excellent photostability, good resistance to hygroscopicity, and a high decomposition temperature tolerance.

Abstract: The present disclosure describes compositions and methods of treating solid tumors using chimeric antigen receptor (CAR) T cell (CAR-T) therapy and/or antibodies targeting uanylate Cyclase 2C (GCC. GUCY2C). The compositions include CAR comprising an extracellular domain that binds GCC. Further disclosed are methods of using modified T ceils expressing a CAR that binds GCC for treating different types of carters.

Abstract: A hybrid transactional/analytical processing database includes an OLTP engine, OLAP engine, and shared storage including a mass storage device holding data of multiple tenants. The shared storage includes processing circuitry configured to implement a query executor configured to continuously monitor actual memory usage of the shared storage while the shared storage is responding to one or more queries from the OLTP engine or OLAP engine. Upon determining the actual memory usage of an operator evaluating the one or more of the queries from the OLTP engine or OLAP engine at the shared storage exceeds the preventative memory usage threshold but does not exceed the system memory usage threshold, the query executor is further configured to spill one or more fragments of query memory corresponding to the one or more queries to the mass storage device, without terminating the one or more queries.

Abstract: Provided are an eye care composition containing L-ergothioneine and a preparation method therefor and use thereof. The eye care composition containing L-ergothioneine provided in the present application includes the following components: L-ergothioneine, taurine, sodium hyaluronate, plant essential oil, p-benzenediboronic acid, an osmotic pressure regulator and water for injection. The preparation method includes mixing the sodium hyaluronate and the water for injection to obtain solution A; mixing the solution A, the taurine, the L-ergothioneine and the p-benzenediboronic acid, and adjusting pH to 5-7.5 to obtain solution B; and mixing the solution B and the plant essential oil, adjusting osmotic pressure to 250-350 mOsm/(Kg·H2O) by adding the osmotic pressure regulator, performing filtration and sterilization, and sub-packaging, so as to complete the preparation method.

Abstract: The present disclosure provides a cutter structure for cutting polylactic acid fiber filter rods and relates to the technical field of cigarette preparation. The cutter structure includes a cutter shaft and cutters, wherein the cutters include a middle cutter and side cutters, the middle cutter is round, and cutting edges of the side cutters are flush with an edge of the middle cutter; hardness of the middle cutter is higher than that of the side cutters, so that the tow middle cutter can be conveniently used for cutting lized tows that have been crystallized in the polylactic acid fiber filter rods; and the side cutters are detachably arranged on side faces of the middle cutter and used for preventing glyceryl triacetate from adhering to the side faces of the middle cutter.

Abstract: Provided is a preparation method for a polylactic acid fiber filter rod with better temperature resistance, which relates to the technical field of cigarette preparation. The method includes the following steps: separately selecting an up-to-standard polylactic acid raw material having the highest content and having the lowest content of the levo-isomer to prepare a core component and a sheath component; forming sheath-core polylactic acid fiber tows; and carrying out forming on a plurality of sheath-core polylactic acid fiber tows to prepare a polylactic acid filter rod. By means of controlling the proportions and preparation of polylactic acid raw materials, so as to improve the uniformity of an inner-layer structure thereof, and the filter performance of the polylactic acid tows is improved.

Abstract: The present invention provides a bispecific chimeric antigen receptor targeting BCMA-CD19 and an application thereof. The bispecific chimeric antigen receptor comprises an extracellular antigen recognition domain; the extracellular antigen recognition domain comprises an anti-BCMA extracellular antigen recognition domain and an anti-CD19 extracellular antigen recognition domain; the anti-BCMA extracellular antigen recognition domain comprises BCMA VH and BCMA VL, wherein amino acid sequences of BCMA VH complementarity-determining regions CDR1, CDR2 and CDR3 respectively comprise amino acid sequences as represented by SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3, and amino acid sequences of BCMA VL complementarity-determining regions CDR1, CDR2 and CDR3 comprise amino acid sequences as represented by SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6.

Abstract: The present disclosure relates to compositions comprising lipid nanoparticles for delivering nucleic acid molecules into cells. Also included are methods for producing and using such compositions.

Abstract: Among other things, the present disclosure is related to devices and methods for containing a liquid sample between two plates.

Abstract: The present invention provides devices, systems, and methods for performing biological and chemical assays.

Abstract: A method includes separately obtaining a to-be-detected image captured by a camera and radar data synchronously collected by a radar sensor; determining a reference line in the to-be-detected image; registering the radar data with the to-be-detected image, where a registered to-be-detected image includes the reference line and a radar line obtained based on the radar data, and the radar line includes pixels in the to-be-detected image that correspond to reflection points corresponding to the radar data; determining, based on the reference line and the radar line, a mask corresponding to the registered to-be-detected image; and inputting the radar data, the to-be-detected image, and the mask into a depth estimation model, to obtain a depth image corresponding to the to-be-detected image.

Abstract: The present disclosure relates to systems and methods for immune therapy. For example, a method can be used to enhance the proliferation of chimeric antigen receptor (CAR) T cells in a subject, The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising one or more lymphocyte activation agents and one or more recombinant viral particles comprising a polynucleotide encoding a CAR, wherein the proliferation of CAR T cells in the subject is greater than in a subject administered with the one or more recombinant viral particles but without the lymphocyte activation agent.

Abstract: Disclosed is an apparatus and method for imaging: a side-view of a object on a surface, a Contact Angle of a liquid object, the color of an object, or combinations thereof.

Abstract: The present disclosure provides a frozen sample holder having an identification ring, and relates to the technical field of freezing sectioning-related equipment, the frozen sample holder having an identification ring comprising an identification ring structure and a frozen sample holder structure, wherein the identification ring structure is in connection with an outer wall of the frozen sample holder structure; and the identification ring structure includes an identification segment, which is configured to mark the information of a sample in the frozen sample holder structure. The present disclosure solves the technical problem existing in the operating process of freezing sectioning all along that multiple samples would easily be confused with each other due to the difficulty to mark frozen sample holders.

Abstract: A method performed by at least one processor in an encoder includes receiving a plurality of frames, each frame including a polygon mesh; selecting one frame from the plurality of frames; performing decimation on the polygon mesh of the one frame to generate a decimated mesh; and encoding, using the decimated mesh, the polygon mesh in at least one frame from the plurality frames excluding the one frame.

Abstract: The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.

Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.