Abstract: Provided herein is a method and device for partitioning a fluidic sample. The device contains a plate containing microwells. The method comprises depositing a sample on one or both of the plates when the plates are in an open configuration, wherein the deposition is in the form of a single or multiple droplet of the sample, wherein at least one of the droplets has a volume that occupies more than two microwells and closing the plates to the closed configuration to partition the sample in the microwells.

Abstract: In the embodiments, ophthalmic formulations comprise 0.001-2% (w/v) of L-Ergothioneine or derivatives of L-Ergothioneine, optionally combined with compatible toxicity agents. L-ergothioneine or derivatives of L-Ergothioneine in the ophthalmic formulation is: (1) an active pharmaceutical ingredient (API) for treating oxidative stress-related ocular disorders; and (2) an inactive excipient for use as a stabilizing excipient to enhance bioavailability and prolong shelf-life of co-administered APIs. L-ergothioneine or derivatives of L-ergothioneine in the ophthalmic solution, when applied on an ocular surface, exhibit: improved corneal permeability; reduced degradation of thermolabile components; and synergistic therapeutic effects when used with other neuroprotective agents, as the co-formulated APIs, in the ophthalmic formulations.

Abstract: The present application discloses a method for adjusting phase of a DQS signal, which is applied to the field of field programmable logic gate arrays and is used to solve the temperature drift problem of the DQS signal in DDR. The method provided by the present application includes: receiving a phase adjustment instruction, and adjusting phase of the DQS signal according to a preset first adjustment rule; receiving a signal sampling instruction to sample the DQS signal, and returning a sampling result of the DQS signal; determining whether the sampling result is correct, and storing a determination result; cycling steps of receiving the phase adjustment instruction to storing the determination result until a number of cycles reaches a preset number of times; according to the determination result corresponding to the number of cycles, adjusting the phase of the DQS signal according to a preset second adjustment rule.

Abstract: A device for liquid sample collection and liquid sample analysis, including: a base plate having: at least one pedestal area in at least a portion of a sample image area; and at least one recessed area, wherein at least of a portion of the at least one pedestal area is adjacent to the at least one recessed area; a cover plate that opposes the base plate; a plurality of spacers attached to one of the base plate, the cover plate, or both, and the spacers are situated between the opposable plates; and an exterior liquid sample contact area on an exterior location of the device; wherein the base plate and the cover plate define an interior cavity in fluid communication with the exterior liquid sample contact area. Also disclosed are an apparatus including the device, a method of making the device, and a method of using the device.

Abstract: Provided herein are processes of producing volixibat and volixibat analogs, or their pharmaceutically acceptable salts, hydrates, or solvates thereof. Further provided herein are compounds of volixibat analogs, intermediates, or their pharmaceutically acceptable salts, hydrates, or solvates thereof. Additionally provided herein are crystalline forms of potassium volixibat salts. Provided herein are pharmaceutical compositions and dosage forms of the compositions comprising the compounds as described herein. Further provided herein are methods and kits of treating liver disease, hyperlipidemia, high cholesterol, arteriosclerosis, or Syndrome X using the compositions comprising the compounds as described herein.

Abstract: Provided are an eye care composition containing L-ergothioneine and a preparation method therefor and use thereof. The eye care composition containing L-ergothioneine provided in the present application includes the following components: L-ergothioneine, taurine, sodium hyaluronate, plant essential oil, p-benzenediboronic acid, an osmotic pressure regulator and water for injection. The preparation method includes mixing the sodium hyaluronate and the water for injection to obtain solution A; mixing the solution A, the taurine, the L-ergothioneine and the p-benzenediboronic acid, and adjusting pH to 5-7.5 to obtain solution B; and mixing the solution B and the plant essential oil, adjusting osmotic pressure to 250-350 mOsm/(Kg·H2O) by adding the osmotic pressure regulator, performing filtration and sterilization, and sub-packaging, so as to complete the preparation method.

Abstract: Systems and methods for performing malware scanning for a service provider network are disclosed. In response to accessing one or more files, file attributes may be determined. Confidence values may be generated based on the file attributes and may be used to select a scan operation. Such scan operations may include a scan operation using a 3rd party malware scan algorithm or a scan operation using a machine learning generated model. The selection of the scan operation may be performed based on a deferral learning model.

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response in vivo. For example, a method of enhancing T cell response in a subject or treating a subject having cancer, the method comprising: administering an effective amount of a composition comprising modified cells to the subject having a form of cancer associated with or expressing an antigen, for example, a solid tumor antigen; and administering (1) a nucleic acid encoding the antigen, (2) additional modified cells comprising the nucleic acid or the antigen, or (3) microorganisms, for example cold viruses, comprising the nucleic acid or the antigen. In embodiments, the modified cells comprise mixed cells targeting a solid tumor antigen and a white blood cell (WBC) antigen. In embodiments, the modified cells comprise a dominant negative form of an immune checkpoint molecule (e.g., PD-1). In embodiments, the modified cells comprise an exogenous polynucleotide encoding a therapeutic agent, such as IL-12 and IFN?.

Abstract: The present application discloses a method of controlling a user display interface of a body fat scale and a body fat scale, the control method comprising: recognizing a foot action of a user in a wake-up state; and controlling a user display interface of the body fat scale based on the foot action. By the above method, the present application is able to improve the convenience of controlling the user display interface of the body fat scale by the user, so as to improve the convenience of interactive operation between the user and the body fat scale.

Abstract: A self-cleaning pet water dispenser, comprising a main body, a clean water tank is detachably arranged on the main body, a wastewater tank is detachably connected to a front side of the main body, a drinking ladle assembly and a water outlet assembly are connected to a front end of the main body and are located above the wastewater tank, the water outlet assembly is communicated with the clean water tank through a water pump, the water outlet assembly comprises a water outlet for filling clean water into the drinking ladle assembly, the drinking ladle assembly is rotatably connected to the water outlet assembly, a drive mechanism is arranged inside the main body, the drinking ladle assembly flips downward under the drive of the drive mechanism and returns to a horizontal position under reverse driving.

Abstract: An electronic vulnerability detection and measuring system and method for susceptibility or vulnerability measurements of a truck fleet to occurring accident events caused by a carriage vehicle of the carriage vehicle fleet. At least one data interface is associated with a data access device to a carriage vehicle fleet database for capturing carriage vehicle data as a fleet input signals from the carriage vehicle fleet database. The carriage vehicle data includes vehicle data including physical parameter measurements of carriage vehicle characteristics for the carriage vehicles, carriage vehicle driver data including physical parameter measurements of driver characteristics and/or carriage vehicle usage data including physical parameter measurements of carriage vehicle usage characteristics.

Abstract: A multicolor (e.g., red, green and blue) direct view display device and methods of fabrication thereof are disclosed. Multicolor light emitting device pixels having a plurality of subpixels configured to emit different color light may be fabricated on the same initial growth substrate and transferred to a second substrate to provide a direct view display device. The multicolor light emitting device pixels may have p-side and n-side contact electrodes of each pixel located on the same side of the structure, which enables functional multicolor light emitting device pixels to be transferred without requiring subsequent backend processing steps to form contact electrodes for the pixels.

Abstract: A thermal control system is configured to transfer heat between refrigerant and coolant. A coolant distribution system includes one or more pumps and valves that are configured to control coolant flow to selectively heat and/or cool a vehicle cabin and/or vehicle components. Measured pump and valve operating parameters may be utilized to repeatedly update metrics that model the states of the pumps and/or valves. Anomalies may be detected by comparing the updated metrics to expected metrics. An alert concerning impending operating issue may be provided based, at least in part, on detected anomalies. A remaining useful life (RUL) of the pumps and/or valves may be determined based, at least in part, on detected anomalies.

Abstract: An electrical control box for superconducting magnet transportation and a device for transporting a superconducting magnet, relating to the field of superconducting magnet transportation, are configured to transport the cryogenic superconducting magnet. The electrical control box for superconducting magnet transportation is provided to address the problem that rated load capacity requirement of the transport apparatus is too high while transporting the superconducting magnet. A function of one input to two outputs is implemented through a power supply distribution module to supply power to a helium compressor and a refrigerator respectively to align with the common practice of transport personnel. In addition, a delay module is arranged in a power supply output connected to the helium compressor to provide power to the helium compressor later than the refrigerator, i.e., the start-up of helium compressor and the refrigerator are asynchronous.

Abstract: A tool for replacing a bushing and seal of an inlet ball valve disc pivot and a method thereof, relating to the technical field of installation and maintenance of hydropower station equipment. The tool for replacing the bushing and seal of the inlet ball valve disc pivot comprises a support frame, a driving ring, a support shaft, a first support assembly and a second support assembly; the support frame includes a first ring, a second ring provided in parallel, and a plurality of connecting rods connected between the first ring and the second ring; the first ring is used for connecting to the ball valve body; the driving ring is provided between the first ring and the second ring in an adjustable position; the driving ring is used for detachable connection with the bushing; the support shaft is used for coaxial connection with the pivot.

Abstract: Provided herein is a method and device for partitioning a fluidic sample. The device contains a plate containing microwells. The method comprises depositing a sample on one or both of the plates when the plates are in an open configuration, wherein the deposition is in the form of a single or multiple droplet of the sample, wherein at least one of the droplets has a volume that occupies more than two microwells and closing the plates to the closed configuration to partition the sample in the microwells.

Abstract: The present disclosure relates to systems and methods for immune therapy. For example, a method can be used to enhance the proliferation of chimeric antigen receptor (CAR) T cells in a subject, The method comprises administering to the subject an effective amount of a pharmaceutical composition comprising one or more lymphocyte activation agents and one or more recombinant viral particles comprising a polynucleotide encoding a CAR, wherein the proliferation of CAR T cells in the subject is greater than in a subject administered with the one or more recombinant viral particles but without the lymphocyte activation agent.

Abstract: Provided is a low-odor, high-stability ergothioneine crystal, which belongs to the field of compound crystals The powder X-ray diffraction pattern of the ergothioneine crystal, measured using Cu-K? radiation and expressed in terms of 2?, has characteristic peaks at least at 9.50±0.2°, 15.52±0.2°, 19.06±0.2°, 24.88±0.2°, 25.48±0.2°, 28.74±0.2°, 29.22±0.2°, and 35.10±0.2°. The new crystal form of ergothioneine has excellent photostability, good resistance to hygroscopicity, and a high decomposition temperature tolerance.

Abstract: The present disclosure describes compositions and methods of treating solid tumors using chimeric antigen receptor (CAR) T cell (CAR-T) therapy and/or antibodies targeting uanylate Cyclase 2C (GCC. GUCY2C). The compositions include CAR comprising an extracellular domain that binds GCC. Further disclosed are methods of using modified T ceils expressing a CAR that binds GCC for treating different types of carters.

Abstract: A hybrid transactional/analytical processing database includes an OLTP engine, OLAP engine, and shared storage including a mass storage device holding data of multiple tenants. The shared storage includes processing circuitry configured to implement a query executor configured to continuously monitor actual memory usage of the shared storage while the shared storage is responding to one or more queries from the OLTP engine or OLAP engine. Upon determining the actual memory usage of an operator evaluating the one or more of the queries from the OLTP engine or OLAP engine at the shared storage exceeds the preventative memory usage threshold but does not exceed the system memory usage threshold, the query executor is further configured to spill one or more fragments of query memory corresponding to the one or more queries to the mass storage device, without terminating the one or more queries.