Publication number: 20250121005
Abstract: The compositions and methods described herein are directed to treating solid tumors using CAR T therapy. For example, the compositions include CAR T cells comprising an extracellular domain that binds OR2I1P, LY6G6D, LRRC15, LY6K, GCC, GFRA4, F2RL2, QRFPR, IQGAP3, SIGLEC15, HAVCR1, PSG9, KISS1R, PRAME, HCN4, DPEP3, TMEM270, HER2, SLC7A3, SPRR2F, SLC45A2, CHRM1, CHRNA2, STEAP1B, FCRL2, Luteinizing hormone receptor, EDB, or CLDN18.2.
Type:
Application
Filed:
January 31, 2023
Publication date:
April 17, 2025
Applicants:
Innovative Cellular Therapeutics Holdings, Ltd., Innovative Cellular Therapeutics, Inc.
Inventors:
Wei Ding, Xiaogang Shen, Xianyang Jiang, Guiting Han, Wensheng Wang, Xudong Tang, Chengfei Pu, Zhiyuan Cao, Zhao Wu, Lei Xiao, Le Tian