Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

Abstract: A method for denoising click data includes: acquiring a set of click data including pieces of first click data and a real label corresponding to each piece of first click data; extracting feature vectors of each piece of first click data with a graph model; dividing the feature vectors into sets of feature vectors; obtaining trained binary classification models by training binary classification models with the sets of feature vectors; for each of the feature vectors, obtaining prediction values corresponding to the feature vector by predicting the feature vector with the trained binary classification models, and calculating a prediction label of the feature vector based on the prediction values of the feature vector; and removing noise data in the pieces of first click data, based on the pieces of first click data, the real label and the prediction label of each piece of first click data.

Abstract: Disclosed is an air conditioning device, including a telescopic main structure, a ventilation air conditioning assembly and a control assembly, the ventilation air conditioning assembly is installed on the main structure, the main structure is configured to form a hermetic space inside it, and is configured to stretch or fold the hermetic space. The ventilation air conditioning assembly is configured to form a differential pressure environment in the hermetic space, the control assembly can be used to control the main structure to stretch or fold, and control the ventilation air conditioning assembly to adjust an air pressure, a temperature and a humidity in the hermetic space.

Abstract: The present disclosure proposes a modeling method and apparatus for diagnosing an ophthalmic disease based on artificial intelligence, and a storage medium. The modeling method includes: establishing a data collection of ophthalmic images and a data collection of non-image ophthalmic disease diagnosis questionnaires; training a first neural network model by employing the data collection of the ophthalmic images to obtain a first classification model; training a second classification model by employing the data collection of non-image ophthalmic disease diagnosis questionnaires; and merging the first classification model and the second classification model to obtain a target classification network model, in which, a test result outputted by the target classification network model is used as a diagnosis result of the ophthalmic disease.

Abstract: The present application provides a positive electrode sheet, a preparation method thereof, and a lithium-ion battery including the positive electrode sheet. The positive electrode sheet includes a positive electrode current collector, and the positive electrode current collector includes a single-sided coated area and a double-sided coated area. In the single-sided coated area, a first coating layer is disposed on a first surface of the positive electrode current collector, the first coating layer includes a first and a second positive electrode active material layer, the second positive electrode active material layer is disposed on the surface of the positive electrode current collector, and the first positive electrode active material layer is disposed on a surface of the second positive electrode active material layer, and a particle size of the first positive electrode active material is larger than a particle size of the second positive electrode active material.

Abstract: A ROR?t inhibitor as well as a preparation method thereof and uses thereof, and a pharmaceutical composition including the compound, a method for preparing the pharmaceutical composition, and use of the compound or the pharmaceutical composition in the treatment or prevention of ROR?t-mediated cancer, inflammation, or autoimmune diseases in mammals, especially humans.

Abstract: The present disclosure provides methods of treating lymphoid malignancies such as B cell malignancies using a BTK inhibitor in the described therapeutic regimens.

Abstract: The present disclosure provides a method for converting numerical values into spikes. The method includes: generating an initial spike sequence according to input numerical values, where the initial spike sequence includes at least one data string, each of which is independently selected from one of a consecutive spike train or a consecutive non-spike train, the number of spikes in all of the at least one data string is equal to an expected value of the number of spikes in a target spike sequence to be generated, and the target spike sequence to be generated is a spike sequence of a spiking neural network within a time period; and randomly selecting and modifying data from the initial spike sequence, so as to form the target spike sequence. The present disclosure further provides an apparatus for converting numerical values into spikes, an electronic device, and a computer-readable storage medium.

Abstract: A method to maintain network service for a mobile equipment includes reading a current integrated circuit card identification (ICCID) value when the mobile equipment supports a hot swap function and a remove interrupt is not triggered by hardware in response to a polling error triggered by a universal integrated circuit card (UICC). The method also includes comparing the current ICCID value to a cached ICCID value captured during a UICC initialization. The method further includes maintaining a current state of the UICC when the current ICCID value matches the cached ICCID value.

Abstract: The invention provides a method, apparatus, device and storage medium for predicting a protein binding site. The method comprises the steps of: receiving a protein sequence to be predicted, dividing the protein sequence by using a preset sliding window and sliding step to obtain a plurality of amino acid sub-sequences, building word vectors for the protein sequence according to the amino acid sub-sequences, extracting document features from word elements, building document feature vectors for the protein sequence according to the extracted document features, extracting protein chain biological features from the amino acid sub-sequences, building biological feature vectors for the protein sequence according to the extracted biological features, classifying the amino acid sub-sequences expressed with the document feature vectors and the biological feature vectors by using a preset amino acid residue classification model to obtain amino acid residue types for the protein sequence.

Abstract: A computing core circuit, including: an encoding module, a route sending module, and a control module, wherein the control module is configured to control the encoding module to perform encoding processing on a pulse sequence determined by pulses to be transmitted of at least one neuron in a current computing core, so as to obtain an encoded pulse sequence, and control the route sending module to determine a corresponding route packet according to the encoded pulse sequence, so as to send the route packet. The present disclosure further provides a data processing method, a chip, a board, an electronic device, and a computer-readable storage medium.

Abstract: A pull cord type turning mechanism for a butterfly-inspired flapping-wing aerial robot includes a motor, a cord reel, a cord reel gear, a potentiometer gear, a potentiometer, a control module, and a power supply. The control module is connected to the motor and the potentiometer. A rotary shaft of the motor is connected to the cord reel, the cord reel is coaxially connected to the cord reel gear, the cord reel gear is meshed with the potentiometer gear, and the potentiometer gear is connected to a rotary shaft of the potentiometer. The cord reel gear is provided with two cord grooves and two pull cords. One ends of the two pull cords are fixed in the two cord grooves, respectively, and the other ends thereof are fixed at the tips of front wings of two sides of the butterfly-inspired flapping-wing aerial robot, respectively.

Abstract: Based on changes in a battery (e.g., age, temperature) of an electronic device, battery power prediction and correction logic of the electronic device may correct a power capability and/or regulate power associated with the battery. For example, the battery power prediction and correction logic may operate the battery to supply up to a maximum of a power capability with an applied correction factor based on a voltage measurement and a cutoff voltage associated with the battery.

Abstract: The disclosed method is applicable to a many-core system. The method includes: acquiring multiple pieces of routing information, each of which includes two logical nodes and a data transmission amount between the two logical nodes; determining a piece of unprocessed routing information with a maximum data transmission amount as current routing information; mapping each unlocked logical node of the current routing information to one unlocked processing node, and locking the mapped logical node and processing node, wherein if there is an unlocked edge processing node, the unlocked logical node is mapped to the unlocked edge processing node; and returning, if there is at least one unlocked logical node, to the step of determining the piece of unprocessed routing information with the maximum data transmission amount as the current routing information.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: The disclosure provides a method for training a tag recommendation model. The method includes: collecting training materials that comprise interest tags in response to receiving an instruction for collecting training materials; obtaining training semantic vectors that comprise the interest tags by representing features of the training materials using a semantic enhanced representation frame; obtaining training encoding vectors by aggregating social networks into the training semantic vectors; and obtaining a tag recommendation model by training a double-layer neural network structure using the training encoding vectors as inputs and the interest tags as outputs. Therefore, the interest tags obtained in the disclosure are more accurate.

Abstract: A flapping-wing aerial robot formation control method includes: determining a trailing vortex generation mechanism, an energy saving principle and a trailing vortex attenuation mechanism of the formation flight of a group of wild geese in accordance with the pattern of the formation flight of the group of wild geese; determining the formation flight of a group of flapping-wing aerial robots and a formation switching solution in accordance with the trailing vortex generation mechanism, energy saving principle and trailing vortex attenuation mechanism of the formation flight of the group of wild geese in conjunction with the flapping characteristic of a flapping-wing aerial robot from the perspective of energy consumption equalization and energy saving; and carrying out formation keeping control and formation reconfiguration control in accordance with the formation flight of the group of flapping-wing aerial robots and the formation switching solution by controlling positions of the group of flapping-wing aeria

Abstract: Disclosed are a fingerprint recognition sensor, a manufacturing method, and a display device. The fingerprint recognition sensor includes a base substrate, a thin film transistor, on a side of the base substrate; and a photosensitive element, on a side of the base substrate away from the thin film transistor, the thin film transistor, the base substrate, and the photosensitive element are sequentially stacked in a thickness direction perpendicular to the base substrate, the base substrate includes a conductive structure penetrating through the base substrate in the thickness direction perpendicular to the base substrate, and the photosensitive element is connected with the thin film transistor through the conductive structure.

Abstract: An imaging system includes: a micro computed tomography (micro-CT) subsystem, a specimen processing subsystem, a scanning electron microscopy (SEM) and a processor. The micro-CT subsystem includes an X-ray source and an X-ray detector, and is configured to acquire a three-dimensional image of a specimen. The specimen processing subsystem includes a focused ion beam subsystem and a mechanical cutting device. The focused ion beam subsystem is configured to process the specimen in a first processing manner, and the mechanical cutting device is configured to process the specimen in a second processing manner to obtain a target section of a target area. The SEM is located above the specimen and is configured to acquire a two-dimensional image of the target section. The processor is configured to perform three-dimensional reconstruction on the two-dimensional images to obtain a three-dimensional imaging of the specimen.

Abstract: The invention discloses a bimetallic cryogenic membrane storage compartment for liquefied natural gas (LNG) storage. The invention is based on the design of bimetallic membrane panels and two insulating panels to achieve two completely independent insulation spaces, fully meeting the relevant requirements of the amendments to the International Code for the Construction and Equipment of Ships Carrying Liquefied Natural Gas in Bulk (“IGC CODE”) adopted on May 22, 2014.