Abstract: A method including determining a database table for which a database index is to be created, wherein the database table comprises a spatial field for storing spatial data; acquiring, for the database table, a spatial filter condition comprising a spatial field ID; and generating, according to the spatial filter condition, a tree-structured spatial index for the database table, wherein a leaf node of the tree-structured spatial index stores therein spatial data meeting the spatial filter condition and its primary key ID. The efficiency of queries related to spatial data is thus enhanced.

Abstract: Common carp sex-determining gene ccMD is used in common carp sex identification and sex control, where the gene is isolated and cloned from common carp and the protein encoded is shown in SEQ ID NO: 3. By utilizing the sequence features of the gene to design specific primers, XX, XY and YY common carp can be rapidly and accurately identified. With the gene serving as a target gene, genetically male but physiologically female common carp, or genetically female but physiologically male common carp, can be rapidly obtained by gene editing technology and gene transfer technology without hormone treatment. The invention uses an accurate genetic target for sex identification and sex-controlled breeding of common carp and provides novel genetic resources for superior germplasm creation in common carp aquaculture and ornamental breeding, as well as for the prevention and control of common carp as invasive alien species.

Abstract: A die includes a plurality of pillar bumps configured to electrically connect the die to a substrate. The plurality of pillar bumps includes at least one first pillar bump having a first total pillar bump height. The at least one first pillar bump includes a first pillar having a first pillar height and a first solder cap having a first solder cap height. The plurality of pillar bumps includes at least one second pillar bump having a second pillar height substantially equal to the first total pillar bump height. The at least one second pillar bump includes a second pillar having a second pillar height and a second solder cap having a second solder cap height. The second pillar height is greater than the first pillar height, and the second solder cap height is less than the first solder cap height.

Abstract: An analyte meter having a test strip ejector. The analyte meter includes a housing body including a front side, a back side, a first side, a second side, an end, and a test strip port at the end configured to receive a test strip; and a strip ejector configured to eject the test strip from the test strip port. The test strip ejector includes a slide member slidable relative to the housing body, an engagement member coupled to the slide member and configured to be contacted by a user, the engagement member located on the back side of the housing body opposite then display screen, and a push member coupled to the slide member and positioned to be engageable with the end of the test strip. Test strip ejectors and methods of ejecting test strips are provided, as are numerous other aspects.

Abstract: The present disclosure provides a chimeric antigen receptor (CAR) immunotherapy for treating a hematologic cancer comprising (a) genetically modifying a population of immune effector cells comprising T cell receptors (TCRs) to stably express at least one CAR, wherein the ectodomain of the CAR specifically binds a cancer antigen; (b) expanding the population of CAR-containing immune effector cells in the presence of one or more cytokines in vitro to achieve a therapeutic dose, wherein the population of CAR-containing immune effector cells exhibits a nonexhausted memory T cell phenotype; and (c) infusing eligible subjects with the CAR-containing immune effector memory T cell phenotype population of cells as needed until the hematologic cancer in the body is destroyed. The intracellular signal transduction domain of the CAR includes 4-1BB, a CD3? T cell activation chain and a genetically engineered TLE3, which can be ectopically expressed.

Abstract: The present disclosure provides a gait analysis method and system, and an apparatus for improving a walking obstacle. The method includes: acquiring three-axis acceleration data and three-axis angular velocity data collected by an inertial sensor, and acquiring pressure data collected by a pressure sensor; performing a quaternion operation on the three-axis acceleration data and the three-axis angular velocity data to acquire three-axis acceleration and a three-axis Euler angle corresponding to a ground coordinate system; identifying a swinging state and a stationary state of feet based on the three-axis acceleration data and the pressure data; analyzing based on the three-axis acceleration, the three-axis Euler angle, and the swinging state and the stationary state of the feet to acquire gait parameters related to a straight walking process, a turning processing, a feet to ground angle, and a feet tremor; and uploading the gait parameters to a server.

Abstract: Provided is a vacuum sealer, comprising a base and a cover, the cover being movably hinged to a rear edge of the base, the base being configured with a vacuum pump, a control circuit board, and a power cord, wherein the vacuum pump is electrically connected to the control circuit board; an upper vacuum chamber and a lower vacuum chamber, wherein the upper vacuum chamber corresponds to the lower vacuum chamber to form a heat-seal area when the cover is closed against the base, wherein the upper and lower vacuum chambers are each configured with a sealing gasket at their peripheries, respectively; a heating sheet assembly electrically connected to the control circuit board being positioned on a front edge of the base opposite to the hinged rear edge; a heat-seal strip being positioned on a front edge of the cover opposite to the hinged rear edge.

Abstract: A super-junction IGBT device with separation gate structures and a preparation method thereof are provided. The super-junction IGBT device includes an epitaxial layer. P-pillars and N-pillars are periodically formed in the epitaxial layer. A P-base region is formed on an upper portion of the epitaxial layer. The separation gate structures are disposed above the N-pillars. An N-base region is formed between the separation gate structures and formed on the P-base region. A first P+layer formed on the N-base region. A second P+layer disposed on a lower end of the epitaxial layer. A back metal is disposed at a lower end of the second P+layer. An emitter metal disposed at upper ends of the separation gate structures and an upper end of the first P+layer.

Abstract: An azacycloalkane compound, a pharmaceutical composition, and use thereof. The compound has a structural formula as shown in formula (I). The azacycloalkane compound and the pharmaceutical composition thereof provided in the present application have significant Rho kinase inhibitory activity, the enzymatic activity and cell activity of the azacycloalkane compound and the pharmaceutical composition thereof are better than those of existing ROCK inhibitors such as Ripasudil, Netarsudil, and Belumosudil, and thus the azacycloalkane compound and the pharmaceutical composition thereof have great potential for application.

Abstract: The present invention relates to use of N-(3-chloro-5-(trifluoromethyl)phenyl)-3-((6-(4-hydroxypiperidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)ethynyl)-2-methylbenzamide (also referred to herein as compound 1) or a pharmaceutically acceptable salt thereof in the treatment or prevention of atopic dermatitis.

Abstract: The present invention relates to use of N-(3-chloro-5-(trifluoromethyl)phenyl)-3-((6-(4-hydroxypiperidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)ethynyl)-2-methylbenzamide (also referred to herein as compound 1) or a pharmaceutically acceptable salt thereof in the treatment or prevention of renal fibrosis and other diseases.

Abstract: The present application relates to a preparation method for a pyrrolopyrimidine compound, comprising: obtaining a compound 3 from a compound 2, obtaining a compound 4P2 from the compound 3, and obtaining a pyrrolopyrimidine compound of formula I by removing a protecting group from the compound 4P2. The preparation method of the present application has the advantages of simple operation, mild reaction conditions and high yield, avoids the problems of low yield and a large amount of impurities and difficult separation of same in original routes, reduces production costs, and is suitable for industrial production. Furthermore, the product yield of each step is high, and basically reaches about 80%, and even the yield of some steps can reach 90% or more.

Abstract: A test device and a method for rapidly determining factors affecting water transparency are provided. The test device comprises a testing pool, a light source, an illumination sensor, an intermediate pool, a water component separating assembly, a stirring assembly and a control system assembly. The light source is above the testing pool. The illumination sensor is at a lower center of the testing pool. The testing pool is communicated with the intermediate pool through pipelines. The illumination sensor measures the transparency of water samples containing different components to determine the influence of each on water transparency. This approach addresses the challenges in quickly diagnosing the causes of low water transparency and analyzing the impact of sudden pollution events with existing technology. Consequently, this test device helps in swiftly identifying the main pollution factors in low-transparency water bodies and provides crucial support for the precise management of such water bodies.

Abstract: Disclosed are a micro-electromechanical system (MEMS) structure and an MEMS microphone comprising same. The MEMS structure comprises a back plate; and a diaphragm located on one side of the back plate, wherein the diaphragm and the back plate forms a variable capacitor, the diaphragm comprises multiple first through holes and air release structures respectively corresponding to the first through holes, and the diaphragm further comprises one or more second through holes penetrating through the diaphragm.

Abstract: A modular multifunctional pelvic fixation hemostatic device is provided, the device includes a fixing strap, a lock catch, an auxiliary fixing assembly, a hemostatic assembly, a press inflator, a perineal pocket, a hemostatic excipient pad and an auxiliary compressing assembly, a patient pelvic position is fixed through the fixing strap and the lock catch, and stability of the fixing strap in the pelvic position is improved through the auxiliary fixing assembly, thus avoiding a movement of the fixing strap during patient transporting and dragging. Great vessels in a junctional area are effectively compressed through the hemostatic assembly, thus ensuring a compression hemostasis effect of the great vessels. The hemostatic excipient pad is in full contact with a wound of the patient through the auxiliary compressing assembly, thus covering and dressing bone protrusions and bone depressions of the patient, and achieving integrated pelvic fixation, wound hemostasis, and dressing.

Abstract: An integrated device comprising a die portion that includes a plurality of pads and a plurality of under bump metallization interconnects coupled to the plurality of pads, where the plurality of under bump metallization interconnects comprises a first under bump metallization interconnect. The integrated device includes a plurality of pillar interconnects coupled to the plurality of under bump metallization interconnects, where the plurality of pillar interconnects includes a first pillar interconnect. The first pillar interconnect includes a first width that corresponds to a widest part of the first pillar interconnect, and a second width that corresponds to a part of the first pillar interconnect that is vertically farthest away from the first under bump metallization interconnect, wherein the second width is less than the first width.

Abstract: The present disclosure discloses a breathing resistance device having an aromatherapy wick, comprising a tubular portion, an end of the tubular portion is provided with a connecting ring, an outer wall of the connecting ring is provided with a hanging chain, the other end of the tubular portion is connected with a dumbbell-shaped suction nozzle, the interior of the tubular portion is provided with an aromatherapy wick, an end of the dumbbell-shaped suction nozzle is provided with a connecting assembly, and the connecting assembly is used for connecting the dumbbell-shaped suction nozzle with the tubular portion.

Abstract: An arrayed high-energy laser counter-UAV (unmanned aerial vehicle) test method and apparatus are provided, relating to the technical field of UAV tests. The method includes the following steps: preparing a test apparatus and a UAV; conducting a laser counter-UAV test; observing an ablation process and analyzing an ablated morphology of the UAV to obtain a radius and ablation depth of a tested ablation area of the UAV; performing finite element simulation on a test process to obtain a radius and ablation depth of a simulated ablation area of the UAV; and comparing the radii and ablation depths of the simulated and tested ablation areas of the UAV, adjusting finite element simulation parameters to make a simulation result coincide with a test result, and deriving an ablation depth-time variation curve of a key point in the simulated ablation area.