Abstract: Two major treatment strategies employed in fighting non-small cell lung cancer (NSCLC) are tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The choice of strategy is based on heterogeneous biomarkers expressed by the lung tumor tissue. A major challenge for molecular testing of these biomarkers is the insufficiency of biopsy specimens from patients with advanced NSCLC. Disclosed herein is a method for predicting a response to immune-checkpoint blockade immunotherapy.

Abstract: A recombinant vector, a lentivirus, a lung-exempt MSLN CAR-T cell, and an anti-tumor agent are provided. The recombinant vector includes a first nucleotide sequence, a second nucleotide sequence, and a third nucleotide sequence, the first nucleotide sequence encodes a mesothelin (MSLN)-binding domain, the second nucleotide sequence encodes a leukocyte immunoglobulin-like receptor (LIR-1), and the third nucleotide sequence specifically binds to a lung-highly-expressed molecule. The lentivirus is constructed using the recombinant vector. The lung-exempt MSLN CAR-T cell is constructed using the recombinant vector or the lentivirus.

Abstract: A PARP inhibitor-tolerant CAR-T cell and its construction method are provided. A sequence of sgRNA for targeted editing PARP1 gene in CAR-T cells includes sg-D45, sg-S588, or sg-G745. The construction method includes using a cytosine base editor to introduce S588F, G745K and/or D45N mutations into the PARP1 proteins in CAR-T cells with the sgRNA, significantly increasing the tolerance of the CAR-T cells to PARP inhibitors and allowing the CAR-T cells to work synergistically with the PARP inhibitors, thereby maximizing the anti-tumor effect.

Abstract: Techniques for transportation speed prediction and transit time estimation are provided. In an example, a computer system generates a first input to a first machine learning model based on temporal information, road segment information, and attribute information for road segments in a geographic region. The computer system receives a first output of the first machine learning model. The first output indicates a predicted speed value associated with a road segment for a transportation resource. The computer system generates a second input to a second machine learning model based on the first input, the predicted speed value, and properties associated with a transportation load. The computer system receives a second output of the second machine learning model. The second output indicates a distribution of a time length for transporting the transportation load using the transportation resource. The second output is usable in deploying the transportation resource for transporting the transportation load.

Abstract: Two major treatment strategies employed in fighting non-small cell lung cancer (NSCLC) are tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The choice of strategy is based on heterogeneous biomarkers expressed by the lung tumor tissue. A major challenge for molecular testing of these biomarkers is the insufficiency of biopsy specimens from patients with advanced NSCLC. Disclosed herein is a method for predicting a response to immune-checkpoint blockade immunotherapy.

Abstract: Filter media including out-of-plane solid elements are generally described. Inventive methods of forming them and uses thereof are also described.

Abstract: A power module packaging structure based on liquid metal, including an upper printed circuit board or an upper cermet substrate, a power semiconductor chip and a lower cermet substrate, wherein a lower surface copper layer of the circuit board is connected with the chip through a soldering layer, a groove is formed in an upper copper layer of the lower cermet substrate through etching, the surface of the upper copper layer of the lower cermet substrate is subjected to silver plating, liquid metal is filled in the groove, and the chip is embedded into the liquid metal to realize electrical connection between the upper surface of the lower cermet substrate and the lower surface of the chip; an insulating sealing ring is arranged on the circuit board around the chip; and the liquid metal absorbs the lower cermet substrate and the upper printed circuit board together through surface tension.

Abstract: Filter media including out-of-plane solid elements are generally described. Inventive methods of forming them and uses thereof are also described.

Abstract: Filter media comprising non-woven fiber webs having one or more advantageous physical properties are generally described. In some embodiments, a filter media and/or non-woven fiber web described herein comprises a combination of fibers that results in enhanced physical properties. For example, the non-woven fiber web may comprise a combination of fiber types that is advantageous, such as a combination comprising fibrillated fibers, glass fibers, and/or binder fibers. In some cases, the filter media and/or non-woven fiber web comprising the combination of fibers may be formed into undulations (e.g., by a creping and/or microcreping process) to further enhance the physical properties of the filter media and/or non-woven fiber.

Abstract: Two major treatment strategies employed in fighting non-small cell lung cancer (NSCLC) are tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The choice of strategy is based on heterogeneous biomarkers expressed by the lung tumor tissue. A major challenge for molecular testing of these biomarkers is the insufficiency of biopsy specimens from patients with advanced NSCLC. Disclosed herein is a method for predicting a response to immune-checkpoint blockade immunotherapy.

Abstract: Provided is a planar power module with a spatially interleaved structure, including a top power substrate, a bottom power substrate arranged opposite to the top power substrate, and a plurality of interleaved switch units configured between the top power substrate and the bottom power substrate; wherein adjacent interleaved switch units are electrically connected through a current commutator so that the interleaved switch units form spatial position interleaving. Problems of uneven parallel currents and uneven heat dissipation in the power module are solved.

Abstract: Filter media including out-of-plane solid elements are generally described. Inventive methods of forming them and uses thereof are also described.

Abstract: Provided is a planar power module with a spatially interleaved structure, including a top power substrate, a bottom power substrate arranged opposite to the top power substrate, and a plurality of interleaved switch units configured between the top power substrate and the bottom power substrate; wherein adjacent interleaved switch units are electrically connected through a current commutator so that the interleaved switch units form spatial position interleaving. Problems of uneven parallel currents and uneven heat dissipation in the power module are solved.

Abstract: A catering and cooking device includes a machine body, a heating unit and/or a flow control unit, a control unit electrically connected to the heating unit and/or the flow control unit to control the heating unit and/or the flow control unit, and a network communication unit electrically connected to the control unit to receive processing process information to control water outlet time of a water reservoir. The catering and cooking device of the present invention receives processing process information corresponding to food via the network communication unit, controls the flow control unit to add liquid such as water or oil according to the received processing process information, and then controls the heating unit to heat according to a preset power map and heating time, the present invention can process different foods in a targeted manner.

Abstract: An antenna comprising first and second radiating elements disposed in a collinear configuration on a dielectric substrate, wherein the first radiating element comprises a feed point. A first inter-element phasing section is conductively coupled to the first and second radiating elements, and has a meander line configuration adapted such that the first and second radiating elements radiate electro-magnetic radiation in-phase over a first range of frequencies. Third and fourth radiating elements are disposed in a collinear configuration on the substrate, and the third radiating element is electromagnetically coupled in parasitic relation to the first radiating element. A second inter-element phasing section is conductively coupled to the third and fourth radiating elements, and has a meander line configuration adapted such that the third and fourth radiating elements radiate electromagnetic radiation in-phase over a second range of frequencies which is different from the first range of frequencies.

Abstract: Search results may include both objective results and person results. In one example, a search query is evaluated to determine whether it is the type of query that a user might want to ask to a friend. If the query is of such a type, then the search engine may examine a social graph to determine which friends of the user who entered the query may have information that is relevant to answering the query. If such friends exist, then the friends may be displayed along with objective search results, along with an explanation of each friend's relevance to the query. Clicking on a person in the results may cause a conversation to be initiated with that person, thereby allowing the user who entered the query to ask his or her friend about the subject of the query.

Abstract: An antenna comprising first and second radiating elements disposed in a collinear configuration on a dielectric substrate, wherein the first radiating element comprises a feed point. A first inter-element phasing section is conductively coupled to the first and second radiating elements, and has a meander line configuration adapted such that the first and second radiating elements radiate electro-magnetic radiation in-phase over a first range of frequencies. Third and fourth radiating elements are disposed in a collinear configuration on the substrate, and the third radiating element is electromagnetically coupled in parasitic relation to the first radiating element. A second inter-element phasing section is conductively coupled to the third and fourth radiating elements, and has a meander line configuration adapted such that the third and fourth radiating elements radiate electromagnetic radiation in-phase over a second range of frequencies which is different from the first range of frequencies.

Abstract: A metal loaded catalyst comprises a support and main active metal components and optional auxiliary active metal components, wherein the main active metal components are elementary substances and obtained by ionizing radiation reducing precursors of main active metal components. The catalyst can be widely used in the catalytic reactions of petrochemistry industry with high activity and selectivity. The catalyst can be used directly without being reduced preliminarily by hydrogen.

Abstract: Disclosed herein are compositions comprising an oxidizer, water, and optionally a neutralizer, and methods of making and using the same. Also disclosed herein are compositions comprising biomass, a biomass-oxidizer, water, and optionally an accelerant, and methods of making and using the same.

Abstract: A system-in-package (SiP) system-integration integrated circuit (IC) chip package and a manufacturing method thereof are provided. The package includes a substrate, a passive device and two IC chips are provided on the substrate, an adhesive film is disposed between each of the two IC chips and the substrate, the IC chips are connected to first pads on the substrate through bonding wires, and the substrate is covered by a mold cap. A third IC chip may be further disposed on one of the IC chips, and the third IC chip is connected to the first pad and the IC chip under the third IC chip respectively through a bonding wire. A substrate adopting a surface mount technology (SMT) PAD window-opening manner is used, chip mounting is performed on the substrate, and the substrate undergoes reflow soldering, cleaning, die bonding, plasma cleaning, bonding, marking, cutting, and packing, so that the SiP system-integration IC chip package is manufactured.