Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: The present disclosure provides a carrier aggregation capability reporting apparatus and method, so as to prevent a user equipment (UE) from repeatedly reporting capability information corresponding to a carrier combination supported by the UE, and reduce waste of signaling resources used for reporting. The method includes: determining, by the UE, information about a carrier combination supported by the UE and information about a sub-combination that is of the carrier combination and that is supported by the UE; and reporting, by the UE to a base station, the determined information about the carrier combination supported by the UE and the determined information about the sub-combination that is of the carrier combination and that is supported by the UE.

Abstract: A tool assembly and an attachment apparatus are provided, including a drive shaft extending along a longitudinal direction and forming a groove. A latch includes a notch configured to extend into the groove at the drive shaft. A coupler extends along the longitudinal direction and forms a cavity extending along the longitudinal direction. A tool end opening is formed at the first end of the coupler through which the drive shaft extends into the cavity along the longitudinal direction. The coupler forms a latch opening extending along the longitudinal direction and into the cavity. The latch is positioned in the cavity through the latch opening. A collar extends at least partially around the coupler. The collar is articulatable along the longitudinal direction around the latch opening.

Abstract: A computer-implemented method, a computer program product, and a computer system for supervised anomaly detection in federated learning. A server in a federated learning system generates a training dataset including malicious data samples and benign data samples. The server trains update-generating models on the malicious data samples and the benign data samples in the training dataset. The server generates benign model updates and malicious model updates, through training the update-generating models. The server trains an anomaly detector on the malicious model updates and the benign model updates. The server deploys the anomaly detector to the federated learning system, for supervised anomaly detection in the federated learning system.

Abstract: A method and apparatus that receive blockchain transaction data from a blockchain ledger to a transaction database, receive intelligence labels from a blockchain ecosystem intelligence database, select a blockchain transaction flow comprising blockchain transactions associated with a digital account source address, digital account intermediate addresses, a digital account destination address, and intermediate transactions, receive input trace parameters, where the input trace parameters include at least one of an objective directional setting, a tracing constraint, and a transaction filter, the transaction filter based on the transaction timestamps and the digital assets transferred, apply the intelligence labels to the digital account source address, the digital account intermediate addresses, and the digital account destination address, apply an artificial intelligence graph search algorithm to the blockchain transaction flow based on the input trace parameters, and generate a report including tracing desti

Abstract: Disclosed are a signaling optimization method and device, to resolve a problem of heavy signaling overheads and long data transmission delay when a user equipment (UE) accesses a network side. The method includes: receiving, by the UE, configuration information sent by a first network side device, where the configuration information includes a list, and the list is a cell list or a base station list; and entering, by the UE, an intermediate state according to the configuration information, where the intermediate state means that: when the UE stores context information of the UE, if the UE moves and a cell movement range falls within a coverage area of a cell or a base station included in the list, the UE performs cell reselection according to the list. Embodiments of the present disclosure are applicable to optimization of signaling transmission between the UE and a network side.

Abstract: A method includes: sending, by a first network device, a first configuration message to a terminal device, where the first configuration message is used to instruct the terminal device to configure a second ciphering/deciphering function associated with a second network device and share a first data packet numbering/reordering function, and the terminal device is configured with the first data packet numbering/reordering function and a first ciphering/deciphering function associated with the first network device; and receiving, by the first network device, a first configuration complete message sent by the terminal device. In this embodiment, the first configuration message is used so that the terminal device may configure the function associated with the second network device. Therefore, during handover, the terminal device may simultaneously perform data transmission with the second network device and the first network device, to reduce or avoid a service interruption time caused by handover.

Abstract: The present disclosure relates to measurement methods, devices, and systems. One example method includes receiving, by a terminal, configuration information sent by a network device, where the configuration information is used by the terminal to measure a to-be-measured object, and measuring, by the terminal, at least one to-be-measured object in an RRC idle mode based on the configuration information to obtain a measurement result of the at least one to-be-measured object.

Abstract: A method includes: sending, by a first network device, a first configuration message to a terminal device, where the first configuration message is used to instruct the terminal device to configure a second ciphering/deciphering function associated with a second network device and share a first data packet numbering/reordering function, and the terminal device is configured with the first data packet numbering/reordering function and a first ciphering/deciphering function associated with the first network device; and receiving, by the first network device, a first configuration complete message sent by the terminal device. In this embodiment, the first configuration message is used so that the terminal device may configure the function associated with the second network device. Therefore, during handover, the terminal device may simultaneously perform data transmission with the second network device and the first network device, to reduce or avoid a service interruption time caused by handover.

Abstract: Disclosed are a signaling optimization method and device, to resolve a problem of heavy signaling overheads and long data transmission delay when a user equipment (UE) accesses a network side. The method includes: receiving, by the UE, configuration information sent by a first network side device, where the configuration information includes a list, and the list is a cell list or a base station list; and entering, by the UE, an intermediate state according to the configuration information, where the intermediate state means that: when the UE stores context information of the UE, if the UE moves and a cell movement range falls within a coverage area of a cell or a base station included in the list, the UE performs cell reselection according to the list. Embodiments of the present disclosure are applicable to optimization of signaling transmission between the UE and a network side.

Abstract: Embodiments of the present application provide a paging method, applied to a wireless communications system. When downlink data to a terminal reaches a first access network device from a core network, the first access network device is triggered to determine a paging parameter of the terminal, and to send, based on the paging parameter, a paging message to the terminal through the first access network device or a second access network device.

Abstract: A user equipment obtains configuration information used to detect a received signal strength indicator (RSSI) value of a signal on an unlicensed frequency, samples the signal on the unlicensed frequency at a sampling interval included in the configuration information to obtain RSSI values of the signal on the unlicensed frequency sampled at sampling moments. The user equipment determines statistics on the RSSI values of the signal on the unlicensed frequency within a statistical window, obtains an RSSI value statistical result of the signal on the unlicensed frequency based on the statistics, and reports the RSSI value statistical result to a base station.

Abstract: The present invention provides an uplink reference signal sending method, and the method includes: sending, by a terminal device, an uplink reference signal on N1 second component carriers within a determined uplink reference signal sending time, and prohibiting, on M1 first component carriers in M first component carriers within the sending time, the terminal device from sending an uplink signal, where the first component carriers are carriers on which scheduling of uplink data transmission is allowed, and the second component carriers are carriers on which scheduling of uplink data transmission is prohibited. N1=M1, in other words, within the sending time, a quantity N1 of second component carriers on which the uplink reference signal is sent is less than or equal to a quantity M1 of first component carriers on which sending of the uplink signal is prohibited.

Abstract: A data transmission method and an apparatus are provided. The method includes: determining, by a base station, a time-domain interval of available time-frequency resources in an unlicensed spectrum, where the available time-frequency resources are continuous time-frequency resources in a time domain; sending, by the base station, a preamble signal in a first subframe in the interval, where the first subframe is an initial subframe in the interval; and sending, by the base station, downlink control information and data after sending the preamble signal, where the data is in the first subframe, the downlink control information includes scheduling indication information, and the scheduling indication information is used to indicate a frequency-domain location of the data. According to the present invention, spectrum utilization can be improved.

Abstract: This application provides a communication method and a communications apparatus. A terminal in an inactive state receives a paging message, and content in the paging message is determined. When the content includes a first identity of the terminal, the terminal sends a first request message to a first access network device, where the first request message carries a non-access stratum (NAS) identifier of the terminal. When the content includes a second identity of the terminal and an identity of an anchor access network device, the terminal sends a second request message to the first access network device. The communication method of is application can adapt to a communication requirement of a terminal in an inactive state.

Abstract: The present disclosure relates to dual connectivity methods. In one example method, a first access network device sends a request message to a second access network device, where the request message is used to request the second access network device to serve as a secondary access network device of a terminal served by the first access network device. Then, the first access network device receives an acknowledgment message from the second access network device, where the acknowledgment message is used to acknowledge to the first access network device that the second access network device agrees to serve as the secondary access network device of the terminal.

Abstract: Embodiments of the present disclosure disclose a mobility management method, user equipment, and a base station. The mobility management method may include: receiving, by user equipment UE in a connected mode, a source identifier of the UE from a first base station, where the source identifier is used to uniquely identify the UE in the first base station; entering, by the UE, a low-overhead state in the case that a low-overhead activation condition is satisfied, where in the low-overhead state, the UE stores a connection context of the UE in the connected mode, and camps on a cell according to a cell reselection criterion during movement; and reporting, by the UE when a first preset condition is satisfied, the source identifier to a second base station to which a second cell belongs, where the second cell is a serving cell on which the UE currently camps.

Abstract: A robotic system includes an instrument including an elongate shaft, a robotic manipulator configured to manipulate the elongate shaft of the instrument, and control circuitry communicatively coupled to the robotic manipulator and configured to determine a first estimated position of at least a portion of the elongate shaft of the instrument based at least in part on robotic command data, determine a second estimated position of the at least a portion of the elongate shaft of the instrument based at least in part on position sensor data, compare the first estimated position and the second estimated position, and generate a third estimated position based at least in part on the comparison of the first estimated position to the second estimated position.

Abstract: An image processing method and apparatus, and a non-transitory computer-readable storage medium are provided. The method includes: acquiring an exposure duration and at least one motion component corresponding to at least one direction within the exposure duration of a current video frame; performing a first noise reduction operation on the current video frame in a two-dimensional space domain in response to a first motion component of the at least one motion component being greater than a preset motion component threshold; and performing a second noise reduction operation on the current video frame in a three-dimensional space domain in response to the at least one motion component being less than the preset motion component threshold.

Abstract: Disclosed is an image processing method, electronic device and storage medium. The method includes obtaining feature information of first region in a current image frame, wherein first region includes a region that is determined by performing motion estimation on the current and previous image frames based on optical flow; obtaining feature information of second region in the current image frame, wherein second region includes a region corresponding to pixel points among first pixel points of the current image frame, where its association with pixel points among second pixel points of the previous image frame satisfies a condition; and based on the feature information of first region and that of second region, fusing the previous and current image frames to obtain a processed current image frame, which is used as a previous image frame for a next image frame.