Abstract: The present disclosure provides compositions and methods related to the detection of mRNA variants. In particular, the present disclosure provides compositions and methods for detecting alternatively spliced mRNA variants using RNA in situ hybridization technology, which can be used to evaluate a disease state (e.g., malignancy) in a subject.

Abstract: A pea-derived peptide with a muscle-building effect and a preparation method thereof, and a drug and use, are disclosed. A pea protein is subjected to enzymatic hydrolysis, and five polypeptides with muscle-building effect are obtained by separation as separate peptide fragments. In an in vitro aging skeletal muscle cell assay, changes are analyzed in a gene expression level of regulatory pathways related to skeletal muscle cell proliferation and differentiation, apoptosis and autophagy, and protein synthesis and degradation. In addition, animal experiments are conducted to study the muscle-building effect and a corresponding mechanism of the pea-derived peptide. This shows that the five polypeptide sequences have a significant muscle-building effect, usable as a polypeptide drug for the treatment of sarcopenia.

Abstract: Anti-CD3 antibodies for use in the diagnosis or treatment of hyperproliferative or autoimmune disorders methods of using the same for detecting and/or treating a hyperproliferative or autoimmune disorders.

Abstract: The invention discloses an effusion cell with a retractable crucible for molecular beam epitaxy, comprising a crucible bracket, a mounting flange, a heat shielding cylinderarranged on an upper side of the mounting flange, a gate valvearranged on a lower side of the mounting flange, an outer cylinderarranged on a lower side of the gate valveand a driving devicefor driving the crucible bracketto move between the heat shielding cylinderand the outer cylinder, the heat shielding cylinderis internally provided with a heater, the outer cylinder driving deviceis hermetically connected to the outer cylinder.

Abstract: An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.

Abstract: The present disclosure provides a random particle generation method based on particle size distribution, which can accord with the particle size distribution characteristics of a geological structure. According to this method, random particle generation is adopted, so that a common spherical structure is avoided, and a generated particle structure is very similar to a real soil structure. Based on actual particle size distribution, particles with different particle sizes are generated by batch generation, particle seeds are generated at random pore locations, and particles are generated based on the seeds. By providing a random particle generation method based on particle size distribution, a soil structure in a form of porous media can be restored by means of simulation, which thus provides a porous medium model for the research of groundwater infiltration and fossil energy exploitation.

Abstract: A method according to certain embodiments generally involves operating a system including an unmanned aerial vehicle (UAV) and a base station. The base station includes a nest including an upper opening having an upper opening diameter and a lower opening having a lower opening diameter less than the upper opening diameter. The lower opening is accessible from within the base station. The method generally includes landing the UAV within the nest such that a portion of the UAV is accessible via the lower opening, releasably attaching a load to the UAV, and operating the UAV to deliver the load to a destination.

Abstract: The present invention provides a speaker box including a housing with a sound hole and a speaker therein. The speaker includes a frame, a vibration system, a magnetic circuit system, and a covering shell. The vibration system includes a diaphragm dividing a receiving room of the housing into a front cavity communicating with the sound hole and a rear cavity, a voice coil assembly. The magnetic circuit system includes a yoke. The covering shell divides the rear cavity into a first rear cavity inside the speaker and a second rear cavity outside the speaker. The covering shell includes a bottom wall and a side wall. A recessing portion formed on the side wall, and the recessing portion communicates the first rear cavity with the second rear cavity.

Abstract: A method for evaluating and optimizing scale management at a subsurface for improved well performance may include performing multiple first tests, where each first test combines a first fluid with a second fluid, wherein the first fluid comprises a concentration of a scale inhibitor and a chemistry of additional fluid components. The method may also include identifying an optimal mixture of the first fluid among the first tests, where the optimal mixture comprises a minimum concentration of the scale inhibitor that reduces scale deposition. The method may further include performing a second test that combines the first fluid with the scale inhibitor, the second fluid, and rock. The method may also include evaluating a concentration of the scale inhibitor in aqueous phase after a period of time after initiating the second test. The method may further include identifying a target fluid for use in a field operation at the subsurface.

Abstract: The present invention relates to a target-oriented seismic acquisition method and apparatus, a medium and a device. The target-oriented seismic acquisition method comprises the steps of: giving parameters of an initial velocity model and a three-dimensional seismic layout aiming to an underground target position; conducting wave field continuation and focusing analysis on the three-dimensional seismic layout, and calculating distribution of seismic energy on the ground in an underground target region; conducting normalization processing on distribution of the seismic energy on the ground, and then conducting level partitioning to obtain a primary energy region and a secondary energy region; adding the number of shot points in the primary energy region to achieve target-oriented acquisition, and obtaining a target-oriented inhomogeneous laying acquired data imaging result.

Abstract: A speaker device is provided. The speaker device includes a frame, a vibration unit and a magnetic circuit unit. The vibration unit and the magnetic circuit unit are fixed to the frame. The magnetic circuit unit is configured to drive the vibration unit to vibrate to produce sound. The magnetic circuit unit includes a yoke. The yoke and the frame are spaced to form a leakage port. The vibration unit includes a diaphragm, a voice coil, and an elastic support assembly. The auxiliary diaphragm has one end fixed to the frame and the other end connected to the voice coil. The auxiliary diaphragm is provided with multiple vents spaced and penetrating the auxiliary diaphragm. The present disclosure can increase the circulation of gases above and below the auxiliary diaphragm, so that a side leakage effect of the speaker device is improved, thereby improving acoustic performance of the speaker device.

Abstract: A speaker device is provided. The speaker device includes a frame, and a vibration unit, a magnetic circuit unit, and air-permeable isolation member. The magnetic circuit unit includes a yoke fixed to the frame. The yoke and the frame are spaced to form a leakage port to enable leaking from a side surface of the speaker device. The sound-producing inner cavity communicates with the leakage port. The air-permeable isolation member completely covers the leakage port. The leakage port communicates with the outside through the leakage hole. Compared with the related art, the speaker device of the present disclosure has a yoke leakage structure, which can realize self-sealing and is conducive to assembling.

Abstract: Disclosed are a kind of fused ring derivatives, and specifically disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof.

Abstract: An embodiment generates an initial set of training data from monitoring data. The initial set of training data is generated by combining outputs from a plurality of pretrained classifiers. The embodiment trains a new classification model using the initial set of training data to identify anomalies in monitoring data. The embodiment performs a multiple-level clustering of the data samples resulting in a plurality of clusters of sub-clusters of data samples, and generates a review list of data samples by selecting a representative data sample from each of the clusters. The embodiment receives an updated data sample from the expert review that includes a revised target classification for at least one of the data samples of the expert review list. The embodiment then trains another replacement classification model using a revised set of training data that includes the updated data sample and associated revised target classification.

Abstract: The present invention relates to a group of glycosyltransferase, and an application thereof.

Abstract: A system and method for storing data associated with a system management interrupt (SMI) in a computer system. Notification of a system management interrupt is received on a central processing unit. The central processing unit enters a system management mode. A system management handler of a basic input output system (BIOS) is executed by a bootstrap processor of the central processing unit. The system management interrupt is initiated via the bootstrap processor. The system management interrupt data is stored in a register of the bootstrap processor. The SMI data is converted to an accessible format. The converted SMI data is stored in a memory.

Abstract: Methods, systems, and storage media for assigning multiple identifiers to user accounts are disclosed. Exemplary implementations may: receive an indication of an event; associate the event with a user; associate the user with at least a first account identifier of a plurality of accounts of the user; associate the user with at least a second account identifier of the plurality of accounts of the user, the second account identifier different than the first account identifier; add at least one of the first account identifier or the second account identifier to a custom audience relating to the event; target the custom audience through directed advertising; and deliver advertisements to the custom audience.

Abstract: A method for evaluating a chemical treatment at a subsurface for improved well performance may include obtaining information about a post-reaction fluid that results from a fluid flowing through a testing vessel for a period of time, where the testing vessel comprises a plurality of materials, where the plurality of materials is designed to be representative of the subsurface, and where the plurality of materials comprises rock and proppant. The method may also include performing, using the information, a compatibility test on the post-reaction fluid and the plurality of materials after the period of time. The method may further include evaluating, after performing the compatibility test, an effect of the post-reaction fluid on the plurality of materials.

Abstract: An angle-of-view testing method for a projection display device, including setting a reference viewpoint at a same side as a reflective surface associated with the projection display device, setting a metrical marker plate with a metrical marker at another side opposite to the reflective surface at a first distance from the reference viewpoint, projecting a testing picture onto the reflective surface by the projection display device, where light of the testing picture is reflected by the reflective surface toward the reference viewpoint, such that a projected image as a virtual image of the testing picture is observed at the reference viewpoint as being projected onto the metrical marker plate, determining the coverage of the projected image with respect to the metrical marker of the metrical marker plate, and determining an angle of view of the projection display device based on the determined coverage.