Patents by Inventor Wei-Wu He
Wei-Wu He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220195047Abstract: This disclosure relates to isolated monoclonal antibodies or antigen-binding fragments thereof that specifically bind to PD-1 and block the interaction between PD-1 and PD-L1/PD-L2. The disclosure also relates to antibodies that are chimeric, humanized, bispecific, derivatized, single chain antibodies, portions of fusion proteins or bispecific antibodies. Nucleic acid molecules encoding the antibodies, hybridomas, and methods for expressing antibodies are also provided. Pharmaceutical compositions comprising the antibodies are also provided. This disclosure also provides use of these antibodies to enhance T-cell function and upregulate cell-mediated immune responses for the treatment and prevention of various diseases.Type: ApplicationFiled: April 17, 2020Publication date: June 23, 2022Inventors: Wei-Wu He, Paul Bryson, Si Li, Donghui Ma
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Publication number: 20120231969Abstract: Illustrative embodiments herein disclosed relate to protein arrays, methods for making the arrays and methods for using them, among others. In some embodiments known proteins representing at least 50% of the loci in the human genome are arrayed in known positions on a support. In some embodiments arrays are made of proteins purified from cell lysates by affinity binding to the support. In some embodiments protein arrays are used to decode the binding specificity of antibodies. In some embodiments protein arrays are used to diagnose auto-immune disorders. Many other embodiments and general features are disclosed.Type: ApplicationFiled: September 23, 2010Publication date: September 13, 2012Applicant: Origene Technologies, Inc.Inventors: Wei-Wu He, Donghui Ma, Youmin Shu, Zairen Sun
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Publication number: 20120115923Abstract: This invention describes compositions and methods using siRNA to target various genes expressed in cells of injured tissue during scar formation to promote scar-free wound healing.Type: ApplicationFiled: December 29, 2006Publication date: May 10, 2012Applicant: Intradigm CorporationInventors: Wei-Wu He, Patrick Y. Lu
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Patent number: 7892773Abstract: The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.Type: GrantFiled: March 31, 2008Date of Patent: February 22, 2011Assignee: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Kenneth C. Carter
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Patent number: 7741055Abstract: The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.Type: GrantFiled: February 23, 2007Date of Patent: June 22, 2010Assignee: Human Genome Sciences, Inc.Inventors: Peter L. Hudson, Craig A. Rosen, Wei-Wu He
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Publication number: 20090142329Abstract: Disclosed are human interleukin-1 ? converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.Type: ApplicationFiled: August 25, 2008Publication date: June 4, 2009Applicant: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Craig A. Rosen, Peter L. Hudson, Gregg A. Hastings
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Publication number: 20080227127Abstract: The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.Type: ApplicationFiled: March 31, 2008Publication date: September 18, 2008Applicant: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Kenneth C. Carter
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Patent number: 7416855Abstract: Disclosed are human interleukin-1 ? converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.Type: GrantFiled: March 17, 2004Date of Patent: August 26, 2008Assignee: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Craig A. Rosen, Peter L. Hudson, Gregg A. Hastings
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Patent number: 7351694Abstract: The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of NKX3.1 activity. Also provided are diagnostic methods for detecting prostate cancer and other cancers and therapeutic methods for prostate cancer and other cancers.Type: GrantFiled: July 8, 2003Date of Patent: April 1, 2008Assignee: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Kenneth C. Carter
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Patent number: 7282351Abstract: The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.Type: GrantFiled: October 15, 2002Date of Patent: October 16, 2007Assignee: Human Genome Sciences, Inc.Inventors: Peter L. Hudson, Craig A. Rosen, Wei-Wu He
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Patent number: 7115260Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.Type: GrantFiled: October 12, 2004Date of Patent: October 3, 2006Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of MichiganInventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
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Patent number: 7083930Abstract: Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.Type: GrantFiled: August 29, 2003Date of Patent: August 1, 2006Assignee: Human Genome Sciences, Inc.Inventors: Peter L. Hudson, Wei-Wu He, Craig A. Rosen, Jeannine D. Gocayne
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Publication number: 20060121490Abstract: The present invention provides articles of manufacture (such as host cell and polypeptide arrays) and methods of use for screening and identifying agents that react with polypeptides. These are useful in a variety of applications, including for diagnostic, therapeutic, drug discovery, and forensic purposes.Type: ApplicationFiled: December 2, 2004Publication date: June 8, 2006Inventor: Wei-Wu He
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Patent number: 7026140Abstract: Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.Type: GrantFiled: September 2, 2004Date of Patent: April 11, 2006Assignee: Human Genome Sciences, Inc.Inventors: Peter L. Hudson, Wei Wu He, Steven M. Ruben
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Patent number: 6890721Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilize such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.Type: GrantFiled: September 24, 2001Date of Patent: May 10, 2005Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of MichiganInventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
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Publication number: 20050089984Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.Type: ApplicationFiled: October 12, 2004Publication date: April 28, 2005Inventors: Vishva Dixit, Wei-Wu He, Kristine Kikly, Steven Ruben
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Patent number: 6835555Abstract: Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.Type: GrantFiled: July 10, 2000Date of Patent: December 28, 2004Assignee: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Craig A. Rosen, Peter L. Hudson, Gregg A. Hastings
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Publication number: 20040171059Abstract: Disclosed are human interleukin-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.Type: ApplicationFiled: March 17, 2004Publication date: September 2, 2004Applicant: Human Genome Sciences, Inc.Inventors: Wei-Wu He, Craig A. Rosen, Peter L. Hudson, Gregg A. Hastings
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Publication number: 20040138117Abstract: Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.Type: ApplicationFiled: August 29, 2003Publication date: July 15, 2004Applicant: Human Genome Sciences, Inc.Inventors: Peter L. Hudson, Wei-Wu He, Craig A. Rosen, Jeannine D. Gocayne
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Patent number: 6733981Abstract: Disclosed are human interlude-1 &bgr; converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury.Type: GrantFiled: July 2, 2001Date of Patent: May 11, 2004Assignee: Human Genome Sciences, Inc.Inventors: Wei Wu He, Craig A. Rosen, Peter L. Hudson, Gregg A. Hastings