Patents by Inventor Wei-Wu He

Wei-Wu He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human choline acetyltransferase
    Patent number: 6245540
    Abstract: Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 12, 2001
    Assignee: Human Genome Sciences, Inc.
    Inventors: Peter J. Hudson, Wei Wu He, Craig A. Rosen, Jeannine D. Gocayne
  • Polynucleotides encoding paraoxonase
    Patent number: 6140093
    Abstract: Human paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: October 31, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Peter L. Hudson, Wei Wu He, Steven M. Ruben
  • Human prostatic specific reductase
    Patent number: 6106829
    Abstract: A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also dislcosed.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: August 22, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Wei Wu He, Paul S. Meissner, Peter L. Hudson, Craig A. Rosen
  • Interleukin-1 .beta. converting enzyme like apoptotic protease-6
    Patent number: 6010878
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: January 4, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
    Patent number: 5994102
    Abstract: The present invention relates to polynucleotides encoding human PGF polypeptides, variant polynucleotides encoding analog polypeptides, and variant polynucleotides useful as probes for polynucleotides encoding human PGF polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: November 30, 1999
    Assignee: Human Genome Sciences, Inc.
    Inventors: Peter L. Hudson, Craig A. Rosen, Wei Wu He
  • Paraoxonase polypeptides and use therefor
    Patent number: 5792639
    Abstract: Human serum paraoxonase enzyme and DNA (RNA) encoding such paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of such polypeptides include their use as an antidote for organophosphate poisoning and to prevent neuronal cell death.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: August 11, 1998
    Assignee: Human Genome Sciences, Inc.
    Inventors: Peter L. Hudson, Wei Wu He, Steven M. Ruben
  • Nucleic acids encoding a TGF-.beta. type 1 receptor
    Patent number: 5538892
    Abstract: Isolated DNAs (e.g., cDNAs or genomic fragments) encoding TGF-.beta. type I receptors, or soluble, ligand-binding fragments thereof; vectors or cells which contain such DNAs; and substantially pure polypeptides encoded by such DNAs, whether produced by expression of the isolated DNAs, by isolation from natural sources, or by chemical synthesis.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: July 23, 1996
    Assignees: The General Hospital Corporation, Duke University
    Inventors: Patricia K. Donahoe, Michael Gustafson, Wei-Wu He, Xiao-Fan Wang