Abstract: Heterocyclic compounds useful as antagonists of adenosine receptors, and methods of treatment of diseases using antagonists of adenosine receptors are disclosed herein. Also disclosed herein are pharmaceutical compositions and methods of administration of heterocyclic antagonists of adenosine receptors and processes for producing heterocyclic antagonists of adenosine receptors.

Abstract: User equipment devices (UEs) may receive multimedia broadcast and multicast service (MBMS) transmissions over a bandwidth part (BWP) specifically allocated for MBMS point-to-multipoint (PTM) transmissions, or over MBMS-specific resources configured for PTM transmissions within a UE-dedicated BWP. The network (e.g. base station) may configure the MBMS-specific BWP for the UE for the PTM transmissions per serving cell. The MBMS-specific BWP may be used for downlink transmissions, and may be cell specific or UE specific per serving cell. The base station may provide MBMS PTM scheduling information per BWP to the UE, may indicate whether a UE-dedicated BWP may be used for PTM scheduling and transmission, and may provide the corresponding scheduling configuration when applicable. The UE may communicate its various capabilities related to MBMS reception and simultaneous reception of PTM and point-to-point (PTP) transmissions to the base station to aid the base station in scheduling communications of the UE.

Abstract: Provided in this document are examples of a multifocal ophthalmic lens. The lens includes a base lens having a base curvature corresponding to a base power; and a diffractive structure comprising a plurality of annular echelettes formed on a first surface of the base lens. The diffractive structure is configured to produce a zero-order diffraction corresponding to a distance vision focal point determined by the base power, the diffraction efficiency of the zero-order diffraction between 45% and 55%; a first-order diffraction having a diffraction efficiency between 5% and 10%; a second-order diffraction corresponding to an intermediate vision focal point, the diffraction efficiency between 15% and 20%; and a third-order diffraction corresponding to a near vision focal point, the diffraction efficiency between 15% and 25%. The diffractive structure includes a plurality of annular diffractive steps, each defined by a profile having a curved slope and a peak.

Abstract: Wireless communications systems and methods related to communicating control information are provided. A method of wireless communication performed by a user equipment (UE) may include monitoring a first set of physical downlink control channel (PDCCH) candidate resources for a PDCCH communication from a network unit, receiving, from the network unit, a plurality of demodulation reference signals (DMRSs), and decoding, based on a metric associated with the plurality of demodulation reference signals (DMRSs) satisfying a threshold, the PDCCH communication.

Abstract: A hidden elastic-loaded handle comprises a handle base and a grip. The handle base includes a guiding portion along a pressing direction of the grip, which has a guiding surface and a limiting portion located on a path of the guiding surface. The grip includes a limiting member that moves along the path of the guiding surface and extends or retracts relative to the guiding surface. A first elastic member is provided within the handle base to drive the grip to bounce out relative to the handle base. When the grip is in a storage state, the limiting member is restricted below the limiting portion, and the first elastic member is compressed. By pressing the grip, the limiting member moves along the guiding surface below the limiting portion, causing the grip to bounce out to a usage state, and the limiting member is positioned above the limiting portion.

Abstract: The application belongs to the technical field of sex identification of Apostichopus japonicus, and particularly relates to a molecular marker for sex identification of Apostichopus japonicus and use thereof. The molecular marker, C77185, has a nucleotide sequence set forth in SEQ ID NO: 1. The molecular marker for sex identification of Apostichopus japonicus provided by this application may realize accurate sex identification of Apostichopus japonicus from different geographical populations, which is characteristic of practicability, accuracy, high efficiency and the like, and may be used in the actual production process. The molecular marker may be further used for in vivo sex identification in related research of the Apostichopus japonicus, thereby conducting experimental research on a specific sex.

Abstract: A device and method for regulating the release of adenosine in an organism, and the use thereof. The device comprises a stimulus generator for generating stimuli of a specific frequency. The use of the device of the present invention in an organism can effectively increase the concentration of adenosine in the brain of the organism, thereby providing an effective strategy for the improvement of sleep disorders.

Abstract: Various embodiments disclosed herein include mechanical iris assemblies, as well as camera modules and devices that incorporate these mechanical iris assemblies. The mechanical iris assemblies described herein include a stator piece, a rotor piece, a set of blade elements, and an actuator arrangement. The actuator arrangement may include a voice coil actuator having at least one magnet carried by the stator piece and at least one coil carried by the rotor piece. The mechanical iris assembly includes a set of springs configured to carry current between the stator piece and the rotor piece to power the coil or coils carried by the rotor piece.

Abstract: Disclosed herein are novel selectable markers and uses thereof. Specifically, provided herein are uses of nucleotide sequences encoding a glutamine synthetase (GS) derived from platypus, turtle, rat, opossum, wombat, or zebra finch as selectable markers for identifying genomic loci with high transcriptional activity or host cells having high productivity of a protein of interest, and/or allowing accelerated cell isolation expressing a protein of interest. Related methods of screening, methods of production, and expression systems are also included.

Abstract: Glass cores including protruding through glass vias and related methods are disclosed herein. An example substrate disclosed herein includes a glass core including a surface and a copper through glass via (TGV) extending through the glass core, the TGV including a protrusion extending from the surface.

Abstract: Provided herein are, inter alia, methods of detecting DNA methylation levels in patients at risk of developing a gastrointestinal cancer, methods of diagnosing a patient with a gastrointestinal cancer based on DNA methylation levels, methods of monitoring DNA methylation levels in patients at risk of developing a gastrointestinal cancer, and methods of treating patients having a gastrointestinal cancer.

Abstract: A computer readable storage medium, a user equipment, a method and an integrated circuit that are used to perform operations. Operations include receiving, from a network, a plurality of Physical Downlink Shared Channel (PDSCH) transmissions in slots of a hybrid automatic repeating request acknowledgement (HARQ-ACK) window, decoding each of the PDSCH transmissions in the slots of the HARQ window, determining a HARQ-ACK feedback for each PDSCH transmission in the HARQ-ACK window, bundling the HARQ-ACK feedback for at least two of the PDSCH transmissions and reporting the bundled HARQ-ACK feedback for the HARQ window to the network.

Abstract: The present invention discloses a manual type C-shaped wire clamp operating device, includes an insulating operating rod, wherein an upper end of the insulating operating rod is provided with a threaded rod, and the threaded rod includes an upper thread and a lower thread; a wire clamp clamping device, wherein the wire clamp clamping device includes a first spring, a wire clamp seat and a floating clamping block located above the wire clamp seat, a wire clamp seat threaded hole is formed in the wire clamp seat, the wire clamp seat threaded hole is in fit connection with the lower thread of the threaded rod; a drainage wire pressing device, wherein the drainage wire pressing device includes a guide rod arranged on the wire clamp seat and a drainage wire pressing block sliding along the guide rod, and a pressing block threaded hole is formed in the drainage wire pressing block.

Abstract: Various apparatuses, systems, methods, and media are disclosed to provide a heat-assisted magnetic recording (HAMR) medium that includes a sacrificial layer and corresponding etching processes to minimize head to media spacing. The medium may include the sacrificial layer and a capping layer where each of the layers is etched to reduce roughness. The sacrificial layer is configured to ensure an etch rate that allows for selective etching and may be deposited on the capping layer and after etching, may remain along grain boundaries of the capping layer. The remaining portions of the sacrificial layer may form a discontinuous layer, including layer segments positioned along grain boundaries of the capping layer. The sacrificial layer may be made of non-magnetic materials different from the materials of the capping layer or materials of an overcoat layer deposited on the etched capping layer.

Abstract: A waterproof structure of a socket connector includes a waterproof housing, a socket, a cable, and a waterproof plug. The waterproof housing includes a wiring opening. The inner surface of the waterproof housing incudes a ring step surface facing the wiring opening. The wiring opening is covered by an end cap. The socket is received in the waterproof housing. The cable is connected to the socket and passes the wiring opening. The waterproof plug wrapping the cable is arranged in the wiring opening to close the wiring opening. The waterproof plug has an inner and an outer end, the inner end faces the socket, and a longitudinal annular rib is arranged on the inner end. The end cover is fastened to the waterproof housing along the longitudinal direction of the waterproof plug to press the outer end to make the longitudinal ring rib press the ring step surface.

Abstract: The present disclosure provides a device and method for measuring a high-temperature resistivity of a tin oxide electrode in a substrate glass furnace, which relates to the field of high-temperature resistivity measurement of tin oxide electrodes. The two ends of a columnar tin oxide electrode are provided with platinum terminals, which are connected to a direct-current dual-arm bridge using platinum wires. The upper and lower side of the columnar tin oxide electrode are provided with fixed insulating spacers that are made of an aluminum oxide material. The device is placed in a high-temperature pit furnace. A heating program is set up to measure the corresponding values of the direct-current dual-arm bridge at different temperatures.

Abstract: In some examples, a peripheral circuit is configured to: when performing a first read operation on memory cells coupled to a selected word line, apply a first pass voltage to a first word line, apply a second pass voltage to a second word line, and apply a third pass voltage to a third word line, wherein the first word line comprises at least one word line physically located above and below the selected word line respectively, both the second word line and the third word line comprise word lines physically located on a side of the first word line away from the selected word line, memory cells coupled to the second word line comprise programmed memory cells, memory cells coupled to the third word line comprise unprogrammed memory cells, and the first pass voltage, the second pass voltage and the third pass voltage are all different.

Abstract: The present invention relates to technical field of C12N15/115, and particularly relates to an aptamer-based fluorescence polarization detection method for extracellular vesicles (EVs) and its application. The method comprises the following steps: S1. immobilizing EVs by interacting with antibodies against surface-biomarker proteins of EVs or surface cancer markers thereof; rapidly washing them to remove free EVs, proteins, membrane fragments, and lipids; S2. respectively adding aptamers matched with EV markers or cancer cell markers therein and cultivating them the aptamers are fluorescently labeled; S3. performing fluorescence polarization detection on the products from Step S2 to achieve qualitative and quantitative analysis of EVs secreted by cancer cells.

Abstract: The present disclosure provides an embodiment of a heat dissipation device for a channel cooling section and an application method, belonging to a field of substrate glass manufacturing technology. The device includes a side refractory brick, a top refractory brick, a bottom supporting refractory brick, and at least one heat sink. The side refractory brick includes a first side refractory brick and a second side refractory brick. The first side refractory brick and the second side refractory brick are arranged opposite to each other. The top refractory brick is spliced above the first side refractory brick and the second side refractory brick, while the bottom supporting refractory brick is spliced below the first side refractory brick and the second side refractory brick. A cavity structure is formed after the splicing is completed.

Abstract: A Ginkgo biloba wuschel-related homeobox 3A (GbWOX3A) gene and an application thereof in plant tissue culture are provided. The GbWOX3A gene is derived from a Ginkgo biloba embryo, the gene sequence of the GbWOX3A gene is SEQ ID NO: 1, and the amino acid sequence encoded by the GbWOX3A gene is SEQ ID NO: 2. An expression of the GbWOX3A gene in developing embryo of Ginkgo biloba and regenerating a callus has specificity, and transgenic function verification experiments prove that overexpression of the GbWOX3A gene can promote regeneration of adventitious buds during the plant tissue culture. Therefore, the GbWOX3A gene has important theoretical significance and application value in the plant tissue culture, and especially plays an important role in improving the regeneration efficiency of gymnosperms.