Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: Sterilization indicators include a first substrate and a second substrate. The first substrate has a compartment containing a fusible indicator material, and a channel in contact with the compartment for the molten indicator material to flow, and a wicking material in contact with the channel. The second substrate has a transparent segment aligned to overlay the wicking material. A high temperature sealing pressure sensitive adhesive layer adheres the first substrate to the second substrate. The adhesive layer includes a (meth)acrylate-based pressure sensitive adhesive matrix and a high temperature sealing agent. The high temperature sealing agent is essentially unreactive at ambient temperature but upon exposure to elevated temperatures forms a heat-sealed adhesive bond.

Abstract: A pharmaceutical composition containing nitroxoline for the treatment of bladder cancer, a nitroxoline oral solid tablet, a preparation method therefor and use thereof. The pharmaceutical composition comprises nitroxoline, a filler, a disintegrating agent, a binder, and a lubricant. The lubricant is selected from one or two of sodium dodecyl sulfate and sodium stearyl fumarate. The pharmaceutical composition has a moderate dissolution rate, can avoid the burst release phenomenon, is moisture-proof and impermeable, has good stability, is secure and effective, is convenient to take, has strong patient compliance, and meets the requirements of being an oral solid tablet. The preparation method has stable production process, good reproducibility, easy mass production, and good clinical use value and social benefits.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A pulse hydrogen supply system for a proton exchange membrane fuel cell is provided. The system comprises a fuel cell, a high-pressure hydrogen bottle, a first pressure relief valve, an ejector, a steam-water separator, a first pressure control valve, a first pressure sensor, a high-pressure vessel, a first electromagnetic valve, a low-pressure vessel, a diaphragm pump, and a second electromagnetic valve. The high-pressure hydrogen bottle, the first pressure relief valve, the first pressure control valve, the ejector and the first pressure sensor are sequentially arranged on a gas inlet pipeline; the high-pressure vessel and the first electromagnetic valve are sequentially arranged on a branch pipeline; the second electromagnetic valve, the low-pressure vessel and the diaphragm pump are sequentially arranged on a first output loop; and the first output pipeline and the gas inlet pipeline form a loop.

Abstract: A data temporary storage apparatus includes a moving unit coupled to a first storage unit and multiple second storage units. The moving unit receives a moving instruction having contents including a read address, a destination address and a predetermined moving rule. The moving unit further executes the moving instruction to fetch input data by row from the first storage unit according to the read address, and to temporarily stores one after another in an alternate and sequential manner the data in each row to each of the second storage units indicated by the destination address. The data moving, data reading and convolution approaches of the present invention implement in parallel data moving and a convolution operation, achieving a ping-pong operation of convolution units and enhancing convolution efficiency, while reducing memory costs since configuring two data storage spaces in a memory is not necessary.

Abstract: An alloy cast strip preparation method includes a melting process and a casting cooling process. The melting process includes controlling a power of an induction melting furnace to perform a cyclic heat treatment to completely melt an alloy raw material before a surface temperature of a melt obtained by melting the alloy raw material is raised to 1300° C., and, after the alloy raw material is melted, adjusting the power of the induction melting furnace to stabilize the surface temperature of the melt at a temperature in a range from 1400° C. to 1500° C. The casting cooling process includes performing casting cooling on the melt arranged on a surface of a rotary cooling roll to obtain an alloy cast strip while controlling a surface linear velocity of the rotary cooling roll to be from 1.5 m/s to 2.25 m/s.

Abstract: The present application relates to biocompatible polymers that exhibit a shape-memory effect, devices made using the materials and methods of producing such materials and devices.

Abstract: Methods and systems for training a neural network include collecting model exemplar information from edge devices, each model exemplar having been trained using information local to the respective edge devices. The collected model exemplar information is aggregated together using federated averaging. Global model exemplars are trained using federated constrained clustering. The trained global exemplars are transmitted to respective edge devices.

Abstract: A curable composition that includes a urethane multifunctional (meth)acrylate, an inorganic filler having a primary particle dimension of at least 200 nm, a photoinitiator system that can be activated by electromagnetic radiation in the range of 340-550 nm, a reactive diluent, and a reinforcing silica having a primary particle dimension of 100 nm of less. The sum of the absolute value of the difference in the refractive index of the filler and the refractive index of the composition cured without filler plus the birefringence of the filler is 0.054 or less, i.e. 0.054?|nfiller?nmatrix|+?filler, where nfiller is the refractive index of the filler, nmatrix is the refractive index of the composition cured without filler, and ?filler is the birefringence of the filler.

Abstract: A temperature control method for a vehicular proton exchange membrane fuel cell system comprises the following steps: detecting a cooling loop inlet temperature of a fuel cell stack by using a temperature sensor, and inputting the temperature into a controller to achieve cooling fan control based on the controller, wherein the cooling fan control comprises fuzzy logic self-adaptive proportional integral control and feedforward compensation control, gain parameters of the proportional integral control are self-adaptively updated by a fuzzy logic algorithm, a load current of the fuel cell serves as disturbance and is used for feedforward compensation, and meanwhile, the opening degree of the fan is determined by the total cooling capacity requirement and the number of cooling fans; and finally, inputting a control signal output by the controller into an actuator of a thermal management subsystem, and conducting cooling inlet temperature control of the fuel cell stack.

Abstract: A piezoelectric microphone, includes: a wafer substrate including a cavity; a plurality of cantilever beams with a piezoelectric deck structure; a fixed column; a plurality of flexible elastic members; and a connecting section. The plurality of cantilever beams each includes a fixed end and a free end suspended above the cavity. The plurality of cantilever beams is of a structure in which one end is narrow and the other end is wide, and the fixed end is relatively narrow. The fixed column is disposed at the center of the bottom surface of the cavity. The fixed ends of the plurality of cantilever beams are all connected to the top surface of the fixed column. A gap is provided between every two adjacent cantilever beams. The plurality of flexible elastic members is connected to free ends of two adjacent cantilever beams to enable the cantilever beams to vibrate synchronously.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided.

Abstract: Dew point sensor system contains-a controller with dew point calculator, ambient temperature sensor, air pathway, heater plate, external wire. Ambient temperature sensor generates ambient temperature data, operatively-connected to controller. Air pathway contains blower within air pathway, air flow sensor within air pathway, liquid reservoir operatively-connected to air pathway, and component may be air pathway temperature sensor and/or breathing circuit heating element. Blower causes air to move in air pathway (52), air flow sensor generates air flow data about air moving in air pathway. The heater plate contains heater plate temperature sensor, and heater plate temperature sensor generates heater plate temperature data. External wire is operatively-connected to controller and component. Ambient temperature sensor located on the external wire.

Abstract: A quantum dot film, a quantum dot light-emitting assembly and a display device are provided. The quantum dot film includes: a quantum dot layer; and a conductive layer arranged on at least a side of the quantum dot layer along a thickness direction, and the conductive layer includes nano-sized metal particles, and at least a portion of the nano-sized metal particles are configured to generate a surface plasmon resonance under electromagnetic radiation. The luminescence efficiency and intensity of the quantum dot layer can be effectively improved by arranging the conductive layer on at least a side of the quantum dot layer.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and X are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The present invention discloses a method of hot recycling repairing by optimizing a proportion of an asphalt mixture on a pavement alignment variation section. According to the method of the present invention, by regulating and optimizing the proportion of a recycled asphalt mixture, internal frictional resistance and cohesion of the recycled asphalt mixture are improved, elastic modulus and shear strength of the recycled asphalt mixture are increased, overall bearing capacity of an asphalt pavement is improved, and diseases such as tracks caused by vehicle loads are effectively resisted. The pavement asphalt mixture is made to adapt to and be enough to bear additional loads increased manifold without generating early defects and road diseases. Therefore, the overall service life of a road is further prolonged.

Abstract: A combined remediation method of petroleum-contaminated soil includes: impurity removal pretreatment, photocatalytic pre-oxidation, stepwise thermal desorption of petroleum from soil, and high-temperature oxidation; with iron-titanium composite metal oxide (ITCMO) as a catalyst, conducting oxidation pretreatment under light conditions so that some cross-linked structures in macromolecular petroleum contaminants are broken and degraded; and conducting stepwise pyrolysis to achieve a removal rate of more than 98.00%. The new method adopts a combined remediation technology of photocatalytic pre-oxidation-stepwise pyrolysis, which realizes a relatively-high removal rate of petroleum hydrocarbons and the efficient and harmless remediation of high-concentration petroleum-contaminated soil, and remedied soil can be reused.

Abstract: A laser printing device for making high-precision 3D products includes a platform, a device supplying and spreading powder for transporting and spreading metal powder on the top surface of the platform, a first laser source for emitting continuous laser beam, a second laser source for emitting pulsed laser beam, an optical path switching device connected with the first laser source and the second laser source for controlling and selecting the first laser source and the second laser source to emit laser beam, a scanning galvanometer system for focusing the laser beam on the platform for making the continuous laser beam melt the metal powder and a layer of a product being formed after cooling, a mechanical processing device for polishing the final surface of the product. The pulsed laser beam cuts the edge of each newly-deposited layer with geometric accuracy. A laser printing method for 3D product is also provided.