Abstract: The disclosure provides an intelligent processing apparatus including a processor and a direct memory access (DMA) controller. The processor generates a read command to read data from a memory. An address generation circuit generates multiple first address signals to the memory. A data processing circuit receives data that the memory outputs in response to the multiple first address signals, and performs a data interception process on the data received from the memory according to the read command and a first configuration parameter. A data port transmits the data processed by the data processing circuit to the processor. The multiple first address signals include multiple non-consecutive address signals such that the data read from the memory and processed by the data processing circuit corresponds to n-dimensional data blocks, where n is a positive integer greater than 1.

Abstract: A convolution calculation apparatus applied for convolution calculation of a convolution layer includes a decompression circuit, a data combination circuit and a calculation circuit. The decompression circuit decompresses compressed weighting data of a convolution kernel of the convolution layer to generate decompressed weighting data. The data combination circuit combines the decompressed weighting data and non-compressed data of the convolution kernel to restore a data order of weighting data of the convolution kernel. The calculation circuit performs calculation according to the weighting data of the convolution kernel and input data of the convolution layer.

Abstract: A convolutional neural network operation device includes a scheduling mode unit, a first data processing circuit, a second data processing circuit and a multiple-accumulate (MAC) operation array. The scheduling mode unit determines, according to a quantity and size information of the target convolutional kernels, a target scheduling mode corresponding to a size of a convolutional computing block. The first data processing circuit recombines weight data in the target convolutional kernels and the second data processing circuit recombines input data in a target convolutional layer according to the target scheduling mode. The MAC operation array includes multiple MAC operation cells, and performs a MAC operation based on the recombined weight data and the recombined input data, wherein a quantity of the MAC operation cells used by the MAC operation array in each round of operation corresponds to the size of the convolutional computing block.

Abstract: The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, and the uses thereof as a SHP2 inhibitor for use in the prevention and/or treatment of tumor or cancer, wherein each substituent in the general formula (I) is as defined in the description.

Abstract: A virtual memory management method applied to an intelligent processor including an operation accelerator includes: determining m storage units from a physical memory, the m storage units forming a virtual memory; dividing the m storage units into n storage groups; determining an address mapping relationship for each storage group to obtain n address mapping relationships, the n address mapping relationship being correspondence of between n virtual addresses of the virtual memory and physical addresses of the m storage units, where m and n are dynamically updated according to requirements of the operation accelerator. In the method, the number of the storage units in each storage group can be configured according to requirements of the operation accelerator, and a data storage bit width and a data storage depth of the virtual memory are dynamically updated to thereby improve data access efficiency.

Abstract: A transdermal peptide with a nuclear localization ability and having an amino acid sequence as shown in SEQ ID NO: 1 is disclosed. A fusion protein including a macromolecular protein with one end being linked to the transdermal peptide is also disclosed. The transdermal peptide can be used in the preparation of a medicament or a transdermal preparation for treating skin diseases. A medicament for treating a skin disease includes the transdermal peptide and a pharmaceutically acceptable excipient. The transdermal peptide enters the cells autonomously to locate in the nuclei, and can penetrate through the stratum corneum of the skin into cells in the dermis. The peptide is conveniently synthesized artificially and suitable for transdermal administration, and has a therapeutic potential via transdermal administration by carrying a drug for treating skin diseases.

Abstract: T cell receptors that specifically recognize hAFP158 and methods of their use are provided.

Abstract: Methods and systems for training a neural network include collecting model exemplar information from edge devices, each model exemplar having been trained using information local to the respective edge devices. The collected model exemplar information is aggregated together using federated averaging. Global model exemplars are trained using federated constrained clustering. The trained global exemplars are transmitted to respective edge devices.

Abstract: An operation method in a convolutional neural network applied to an electronic apparatus having a memory storing convolutional kernel data having undergone a sorting process. The operation method includes: performing the sorting process on a first feature vector of feature map data under process according to a marking sequence corresponding to a first weighting vector of the convolutional kernel data having undergone the sorting process; removing a part of feature values in the first feature vector having undergone the sorting process to generate a second feature vector; and performing a multiply accumulation operation on the basis of the first weighting vector and the second feature vector. The convolutional kernel data having undergone the sorting process is obtained by means of performing sorting and zero-weighting removal processes, and the marking sequence is generated according to the sorting and zero-weighting removal processes corresponding to the first weighting vector.

Abstract: A modified vertebrate cell comprising a vertebrate cell encased in reversibly interlinked metal-organic framework (MOF) nanoparticles, and methods of making and using the modified cell, are provided.

Abstract: Adhesive compositions comprise a polyester polyol that includes residues of at least one 2, 2, 4, 4-tetraalkylcyclobutane-1, 3-diol, including, for example, 2, 2, 4, 4-tetramethylcyclobutane-1, 3-diol (TMCD). Adhesive compositions as described herein exhibit enhanced properties as compared to conventional adhesive compositions, and may be suitable for a wide variety of end use applications, including, flexible packaging, woodworking, automotive uses, and electronics.

Abstract: An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided.

Abstract: Disclosed are methods and apparatuses for fabrication of polymer scaffolds and biological tissues in the multi-well plates in a rapid, high-throughput, controllable and reproducible manner by using optical exposure of the wells to patterned probe light without using a photomask. In some aspects, an apparatus includes a light source to produce a probe light; a digital display device to spatially modulate the probe light to encode a programmable spatial pattern in a spatially-modulated light; a stage to hold a target surface or chamber, wherein the target surface or chamber contains a solution including a material that forms a scaffold or construct based on interaction with the spatially-modulated light projected at the solution; and a computer control device in communication with the light source and the digital display device to control a change of the solution including the material to form the scaffold or construct.

Abstract: The disclosure provides a power supply device with temperature control and an electronic cigarette, wherein the power supply device includes a housing, a battery arranged in the housing, an electrical connection assembly disposed at a first end of the housing, a temperature control board and an airflow sensor disposed in the housing, and a lamp cap dispose at a second end of the housing; the electrical connection assembly and the airflow sensor are electrically connected with the temperature control board respectively, and the temperature control board is electrically connected with the battery. The power supply device with temperature control has temperature control function, which can avoid phenomena such as dry burning of an atomizer of the electronic cigarette; the power supply device has less structural members, low cost and easy assembly, the volume is reduced compared with the power supply device in the prior art, which is more portability.

Abstract: A backlight source, a backlight module and a display device are provided. The backlight source includes a light source and a polarizer component, the light source is configured to emit light to the polarizer component, the polarizer component is configured to convert the light emitted from the light source into polarized light, and the polarizer component includes a birefringent material. The backlight source emits linearly polarized light by using the birefringent material.

Abstract: Biphasic tissue constructs that include a scaffold having one or more channels, a vascular portion comprising a hydrogel at least partially disposed in the one or more channels, and a first bioactive growth factor and a second bioactive growth factor different from the first bioactive growth factor, the first bioactive growth factor localized to the scaffold and the second bioactive growth factor localized to the vascular portion. The first bioactive growth factor may be bone morphogenetic protein 2 (BMP2) peptide and the second bioactive growth factor may be vascular endothelial growth factor (VEGF) peptide.

Abstract: The present invention relates to a modified sintered Nd—Fe—B magnet, and a preparation method and a use thereof. The modified sintered Nd—Fe—B magnet is prepared by performing grain boundary diffusion on a matrix, wherein the matrix is a sintered Nd—Fe—B magnet; a grain boundary diffusion source for the grain boundary diffusion consists of a first diffusion source and a second diffusion source; the first diffusion source is a PrMx alloy, M being at least one selected from a group consisted of Cu, Al, Zn, Mg, Ga, Sn, Ag, Pb, Bi, Ni, Nb, Mn, Co, Fe, Ti, Cr, Zr, Mo and Ge; and the second diffusion source is heavy rare earth Dy and/or Tb.

Abstract: An extendable display screen structure, wherein a hollow part is provided on at least one side of a main base and two guiding components are symmetrically provided in the main base along two sides of the hollow part; at least one driving component is provided in the main base, and the driving component is provided with a power source to drive the driving component to move along the guiding component; at least one side of a flexible screen is wound around an outer periphery of at least one rotating shaft, the rotating shaft is rotatably disposed on a side of the driving component and forms linkage, the driving component, in linkage with the rotating shaft, moves along the guiding component out of the main base, whereby the flexible screen can be gradually released from the outer periphery of the rotating shaft to be extended outwards, and on the contrary, the driving component, in linkage with the rotating shaft, gradually moves into the main base, whereby the rotating shaft retracts the flexible screen.

Abstract: Methods, systems, and software are provided for estimating a circulating tumor fraction for a test subject. Sequence reads are obtained from a panel-enriched sequencing reaction, including sequences for a first plurality of cfDNA fragments corresponding to probe sequences and a second plurality of cfDNA fragments not corresponding to probe sequences. Bin-level coverage ratios are determined from the sequences. Segments are formed by grouping adjacent bins based on similar coverage ratios and segment-level coverage ratios are determined based on bin-level coverage ratios for bins in the segment. For each simulated circulating tumor fraction in a plurality of circulating tumor fractions, segments are fitted to an integer copy state by identifying the integer copy state that best matches the segment-level coverage ratio.

Abstract: Methods, systems, and software are provided for validating a copy number variation in a test subject. A first dataset is obtained comprising bin-level sequence ratios, segment-level sequence ratios and segment-level measures of dispersion. Bins representing regions of a human reference genome are determined from sequencing cell-free nucleic acids in a liquid biopsy sample and reference samples. Segments encompass subsets of adjacent bins, where segment-level sequence ratios and measures of dispersion are determined using bin-level sequence ratios. A copy number status annotation for a segment is validated by applying the first dataset to a plurality of filters comprising a measure of central tendency bin-level sequence ratio filter, a confidence filter, and a measure of central tendency-plus-deviation bin-level sequence ratio filter. When a filter is fired, the copy number status annotation of the segment is rejected; and when no filter is fired, the copy number status annotation of the segment is validated.