Abstract: The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 and NS2 gene deficient RSV (?NS1/NS2 RSV), and its usage to treat different types of human melanoma by killing cancer cells with in vitro evidences.

Abstract: Preparation and application of line leaf inula flower lactone A in the multiple sclerosis, having a structure of Line leaf inula flower lactone A has therapeutic effects on experimental autoimmune encephalomyelitis (EAE) model, and is used to develop drug for treating multiple sclerosis (MS). Line leaf inula flower lactone A drug is a combination containing the active ingredient of line leaf inula flower lactone A and conventional pharmaceutically carrier, and may be in forms of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol. The pharmaceutical composition is used for treating multiple sclerosis, has tremendous developing potentiality because of its high value of clinical application.

Abstract: Preparation and application of line leaf inula flower lactone A for treating myocarditis having a structure of The compound shows positive therapeutic activity against Coxsackie virus and significant dose dependent correlation. The line leaf inula flower lactone A prevents disease in mouse models of experimental autoimmune myocarditis and onset of the process by intraperitoneal injection of a dose of 20 mg/kg/d. When increased to 100 mg/kg/d, the line leaf inula flower lactone A shows positive therapeutic effect on EAM. Line leaf inula flower lactone A is used as the sole active ingredient and combined with a conventional pharmaceutical carrier in a drug for treating myocarditis, and the pharmaceutical composition may be in the form of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol.

Abstract: A connecting terminal is disclosed having a wire connection portion with at least one pair of side arms, and an abutting portion attached at a second end to the wire connection portion. The Abutting portion includes at least one mating terminal receiving chamber and a locking structure. The locking structure includes a locking surface facing the wire connection portion and extending perpendicularly to an insertion direction of the connecting terminal, a first locking surface formed on an upper side of the abutting portion and a second locking surface formed on a lower side of the second end of the abutting portion.

Abstract: A method for treatment of malaria including administering to a patient in need thereof a flavonoid glycoside compound.

Abstract: The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression cassette encodes a polypeptide of interest, and wherein the gene suppressing cassette encodes a short interfering RNA (siRNA) molecule that reduces expression of a target gene by RNA interference. The present invention further includes vectors that contain suppressor cassettes in conjunction with cassettes upregulating gene expression regulated by either a constitutive promoter, such as a general CMV promoter, or a tissue specific promoter. The present invention further includes vectors that contain Dengue virus gene suppression cassettes. The present invention further includes pharmaceutical compositions containing such vectors, methods of modulating the expression of genes in a host using such vectors, and method of producing such vectors.

Abstract: A keyboard type terminal and a location method for electronic document therein are disclosed. The keyboard type terminal includes a setting module, a directory listing module, a detection module, a real-time directory module, a preview module and a chapter and section switchover module.

Abstract: A method for processing a document by a terminal with a touch screen and a terminal with a touch screen are provided, wherein, the method includes: the terminal storing a control region corresponding to a document operation and an operation mode for the control region; the terminal monitoring the control region, and when it is determined that the monitored operation mode for the control region is coincident with the operation mode for the control region stored by the terminal, operating the document according to the document operation corresponding to the control region. The above method for processing a document by a terminal with a touch screen and a terminal with a touch screen enable the user to set up the operation region on different positions of the touch screen flexibly, thus largely improving the reading experience of the user.

Abstract: A method and system for validating integrated circuit designs that are built with encrypted silicon IP blocks decrypts the encrypted silicon IP blocks in the integrated circuit designs with the keys from IP providers. After decryption, various validation checks on the integrated circuit designs are done, such as design rule check (DRC), layout versus schematic (LVS) check, parasitic resistor capacitor (RC) extraction, circuit simulation, signal electro migration (EM) and voltage drop check, signal integrity (SI) check and static timing check, etc. After validation, any confidential data from the checking results related to the encrypted silicon IP blocks are themselves encrypted to protect the proprietary silicon IP blocks. The method and system work with silicon IP encryption technology to establish a low cost silicon IP usage and verification platform, and to enable a more cost efficient silicon IP business model.

Abstract: The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat breast cancer by killing cancer cells with in vitro and in vivo evidences.

Abstract: A method and a system to present a personal shopping experience are provided. A plurality of items assigned to a category inputted by a user is identified. The plurality of items is available for sale at a plurality of corresponding locations within a pre-defined geographical area. A selection of at least one item of the plurality of items, the category, or a region within the pre-defined geographical area is received from a user. A path from a first location corresponding to a first item of the plurality of items to a second location corresponding to a second item of the plurality of items is determined. The path is within the pre-defined geographical area where the system is located. Discount information for the first item and discount information for the second item are identified. A path from the first location to the second location is displayed to the user. Discount information for the first item and the second item are provided to the user.

Abstract: A method and system for validating integrated circuit designs that are built with encrypted silicon IP blocks decrypts the encrypted silicon IP blocks in the integrated circuit designs with the keys from IP providers. After decryption, various validation checks on the integrated circuit designs are done, such as design rule check (DRC), layout versus schematic (LVS) check, parasitic resistor capacitor (RC) extraction, circuit simulation, signal electro migration (EM) and voltage drop check, signal integrity (SI) check and static timing check, etc. After validation, any confidential data from the checking results related to the encrypted silicon IP blocks are themselves encrypted to protect the proprietary silicon IP blocks. The method and system work with silicon IP encryption technology to establish a low cost silicon IP usage and verification platform, and to enable a more cost efficient silicon IP business model.

Abstract: The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat lung cancer by killing cancer cells with in vitro and in vivo evidences.

Abstract: A method for treatment of malaria including administering to a patient in need thereof a flavonoid glycoside compound.

Abstract: This invention discloses a method by colored solution to prevent missing a solution in experiment.

Abstract: A method and system for protecting silicon IPs from unauthorized use, transfer and sale, and for hiding confidential technology information contained in silicon IPs is described. The method and system create a content-encrypted silicon IP layout database from its original layout database. Both the layout database may be GDSII files, OASIS files, or other format layout database file, in which multiple records sequentially build the layout database. In accordance with one preferred embodiment, first, the original layout database is parsed and saved as sequential records in the memory. Next, the structure records, which construct structures in the original layout database, are selected from the saved records. Once the structure records have been selected, the data of the structure records may be compressed with using a public compressing method, and may be encrypted with using a public cryptography algorithm.

Abstract: No effective vaccine exists for the devastating parasitic disease of Schistosomiasis. The present invention focuses on Sm-p80, a functionally important antigen of Schistosoma mansoni that plays a pivotal role in the schistosome immune evasion process. When used in a novel vaccine formulation, Sm-p80 demonstrates consistent immunogenicity, protective potential, and antifecundity effects. Two novel DNA constructs were made for immunization purposes. Sm-p80 coding sequence was cloned into VR 1020. Additionally, Sm-p80 coding sequence was cloned into pcDNA3.1 with flanking CpG motifs on each end of the Sm-p80 sequence. When used in different vaccine formulations, both of the constructs demonstrate the superior antifecundity and anti-worm effects of Sm-p80, which has great potential as an important vaccine candidate for the reduction of the morbidity associated with schistosome infection.