Abstract: The invention provides a method for making silicone hydrogel contact lenses. The method of the invention is characterized by using an organic solvent as a processing-aid tool for controlling lens diameter without significantly affecting lens equilibrium water content during cast-molding of soft contact lenses from a polymerizable composition. By adjusting the weight percentage of the organic solvent in a polymerizable composition for making SiHy contact lenses, one can adjust lens diameter of produced SiHy lenses to meet target without affecting adversely the lens properties.

Abstract: The present invention generally relates to silicone hydrogel contact lenses each inherently having, on lens surfaces, a relatively-high concentration of primary amino groups and to a method for producing the same. The invention is also related to silicone hydrogel contact lens precursors each inherently having, on lens surfaces, a relatively-high concentration of N-Boc-protected primary amino groups which can be easily and conveniently deprotected during lens extraction and/or hydration steps.

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

Abstract: A water soluble silicone macromer comprising a siloxane backbone having grafted thereto a suitable number of hydrophilic groups to render the macromer water soluble, the macromer comprising a polymerizable functional group grafted to the siloxane backbone. In one aspect, the present invention provides a water soluble silicone macromer having a structure of Formula (1): where M is a hydrophilic group or segment; L is a hydrophilic or hydrophobic linkage; N is a hydrophilic or hydrophobic group or segment. Q is a polymerizable functional group; x is zero or an integer greater than zero; y is zero or an integer greater than zero; v is zero or an integer greater than zero; and z is greater than zero, with the proviso that both y and v are not zero.

Abstract: A water soluble silicone macromer comprising a siloxane backbone having grafted thereto a suitable number of hydrophilic groups to render the macromer water soluble, the macromer comprising a polymerizable functional group grafted to the siloxane backbone. In one aspect, the present invention provides a water soluble silicone macromer having a structure of Formula (1): where M is a hydrophilic group or segment; L is a hydrophilic or hydrophobic linkage; N is a hydrophilic or hydrophobic group or segment. Q is a polymerizable functional group; x is zero or an integer greater than zero; y is zero or an integer greater than zero; v is zero or an integer greater than zero; and z is greater than zero, with the proviso that both y and v are not zero.

Abstract: A silicone hydrogel comprising monomeric units of one or more amino monomers, wherein the amino monomers are of formula IA, IB, IIA or IIB and monomeric units of one or more silicone monomers wherein R1, R2 and R3 are independently selected from hydrogen, C1-C6 alkyl or CH2OH; R4 is a C1-C10 alkyl optionally substituted with hydroxyl or carboxylic acid; E is a polymerizable group; X is an anion suitable for quaternary nitrogen; and n is 0, 1, 2, or 3 and m is an integer from 1 to 8.

Abstract: Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to surface modifying polymers.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.

Abstract: A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.

Abstract: Polysiloxanes having vinyl or epoxy functionality. The polysiloxanes are used to form polymer-based materials having properties particularly suited for biomedical device applications. The polysiloxanes are of general formula I: wherein R is a C2-10 alkenyl, a C2-10 alkyl with an epoxy group or a C5-C7cycloalkyl with an epoxy group; R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, optionally substituted phenyl and optionally substituted benzyl; A is —OH or —NHR5, wherein R5 is hydrogen or a C1-3 alkyl; and B is —R1-A or —R6, wherein R1 is a linking group having an alkylene group with 2 to 8 carbon atoms wherein the alkylene group optionally includes ether, urethane or ureido linkages; and R6 is selected from the group consisting of C1-4 alkyl, optionally substituted phenyl or optionally substituted benzyl; and m and n are integers with an m:n ratio from 30:1 to 3:1.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device-forming comonomer.

Abstract: Prepolymers comprising at least one block of Formula II and terminated with a polymerizable ethylenically unsaturated radical are useful in hydrogel materials are disclosed: wherein n, R, R1, R2 and X+ are as defined herein.

Abstract: A polysiloxane prepolymer that is useful for forming biomedical devices has the formula: M(*Dii*PS)x*Dii*M??(I) wherein: each M is independently a polymerizable ethylenically unsaturated radical; each Dii is independently a diradical residue of a diisocyanate; each PS is independently a diradical residue of a polysiloxane-diol or a polysiloxane-diamine; each * is independently —NH—CO—NH—, —NH—COO— or —OCO—NH—; and x is at least 2.

Abstract: Polysiloxanes having vinyl or epoxy functionality. The polysiloxanes are used to form polymer-based materials having properties particularly suited for biomedical device applications. The polysiloxanes are of general formula I: wherein R is a C2-10 alkenyl, a C2-10 alkyl with an epoxy group or a C5-C7cycloalkyl with an epoxy group; R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, optionally substituted phenyl and optionally substituted benzyl; A is —OH or —NHR5, wherein R5 is hydrogen or a C1-3 alkyl; and B is —R1-A or —R6, wherein R1 is a linking group having an alkylene group with 2 to 8 carbon atoms wherein the alkylene group optionally includes ether, urethane or ureido linkages; and R6 is selected from the group consisting of C1-4 alkyl, optionally substituted phenyl or optionally substituted benzyl; and m and n are integers with an m:n ratio from 30:1 to 3:1.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a hydrophilic polymer having one or more non-ethylenically-unsaturated carboxylic acid terminal groups.

Abstract: Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.

Abstract: A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising one or more hydrophilic polymers having one or more non-ethylenically-unsaturated carboxylic acid terminated groups.

Abstract: Biomedical devices are provided herein which are formed from a polymerization product of a mixture comprising (a) a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers; and (b) a biomedical device-forming comonomer.