Abstract: The present disclosure relates generally to a therapeutic system and method to manage and modulate inflammation by reducing inflammation with enhanced anti-inflammatory measures. Using a light source such as light emitting diodes (LEDs) or a laser light source, the photons can be used to applied to increase the efficacy of medicine on the organ (i.e., disease site) that needs treatment by imparting the light rays only to the site rather than the whole body. The photons produced by the light source increase adenosine triphosphate (ATP) to improve the functional selectivity of G Protein-Coupled Receptors (GPCR). With the increased efficacy of medicines to the disease site, the dosage of medicine can be reduced to minimize the side effects in particular to other parts of the body. The treatment may be used to treat inflammation caused by corona virus of 2019 (COVID-19) infection.

Abstract: A flip-chip light-emitting diode includes a first conductivity type semiconductor layer, a light-emitting layer, a second conductivity type semiconductor layer, a first transparent dielectric layer, a second transparent dielectric layer, and a distributed Bragg reflector (DBR) structure which are sequentially stacked. The first transparent dielectric layer has a thickness greater than ?/2n1, and the second transparent dielectric layer has a thickness of m?/4n2, wherein m is an odd number, ? is an emission wavelength of the light-emitting layer, n1 is a refractive index of the first transparent dielectric layer, and n2 is a refractive index of the second transparent dielectric layer and is greater than n1.

Abstract: Disclosed are polymersome nanoparticles that comprise a combination of drugs: (i) a ubiquitin-proteasome system (UPS) inhibitor; and (ii) a macropinocytosis inhibitor. Also disclosed is a method of treatment of cancer using the nanoparticles. Disclosed is a method of treatment of tumor having nutrient-deprived microenvironment, such as deficient in amino acids. The disclosure is directed to a combination of drugs for starvation of tumor cells comprising the use of nanoparticles which inhibits degradation of proteins in the tumor cells and prevents internalization of proteins into the tumor cells. Also provided are compositions and methods for affecting cell proliferation, metabolism or sensitization, including proteasome inhibitor therapy for the treatment of disease caused by deregulation of ubiquitin-proteasome systems, in a cell or subject.

Abstract: The present disclosure generally relates to various phototriggered drug release and photoreactions, including reactions generally based on triplet-triplet energy transfer with light excitation at long wavelengths. One aspect of the present disclosure is directed to systems and methods for absorbing energy in a photosensitizer, transferring that energy by triplet-triplet energy transfer to cleave a cleavable or other active moiety causing the release of a releasable moiety. One aspect relates to a composition comprising a photosensitizer which is capable of singlet-to-triplet (S-T) activation at a near-infrared (NIR) wavelength, a cleavable moiety to accept triplet-triplet energy transfer from the photosensitizer in a higher energy state to cause cleavage of the cleavable moiety, and a releasable moiety releasable from the composition upon cleavage of the cleavable moiety. Such systems and methods may be used in various biological or physical applications.

Abstract: The subject invention pertains to photocleavable prodrugs that facilitate the controllable drug delivery to the target sites modulated by light irradiation, including a photocleavable boron-dipyrromethene-derived prodrug and a dye, which achieved both high prodrug loading capacity (˜99%) and efficient light-triggered prodrug activation. The incorporation of the dye not only stabilized the nanoparticles and contributed tumor targeting as usual. but also exhibited degradation after light irradiation and in-situ monitoring of nanoparticle dissociation by fluorescent imaging.

Abstract: An integrated display with antenna is used in wireless communications devices, including mobile phones and Augmented Reality and Virtual Reality (AR/VR) devices, to enhance radio frequency coverage while minimizing the overall sized of the wireless communication devices. The antenna's geometry can be precisely determined by manipulating the conductive and dielectric pixels within the display panel. The dielectric material within the display panel can be composed of metamaterials. Additionally, the antenna in the display panel can be structured as an antenna array. This array configuration optimizes mobile device coverage and performance by shaping and directing the radiation pattern of signals.

Abstract: Provided is a singlet oxygen-cleavable anti-VEGF prodrug. Provided is a composition comprising a photosensitizer and biocompatible polymer for the co-assembly of photoactivatable nanoparticles with the singlet oxygen-cleavable anti-VEGF prodrug. This red-light-activatable prodrug composition can be used in methods for the combined anti-angiogenesis and PDT treatment of wet AMD and other diseases, capable of light-controllable drug delivery to the CNV lesions and other disease sites via noninvasive intravenous administration.

Abstract: A wireless hub includes a vehicle power connector that can draw power from a vehicle battery on a vehicle, a first wireless transmission circuit that can send or receive data with base stations in a long-range wireless network, a second wireless transmission circuit that can provide a short-range wireless network and to transfer data to and from electronic devices, and a network processor that can process data in the first wireless transmission circuit and the second wireless transmission circuit. The wireless hub has an antenna array for millimeter wave communications. Antenna array beamforming techniques can be applied in various wireless systems, including cellular networks, Wi-Fi, radar systems, and satellite communications, to improve coverage, capacity, and link quality. Using antenna arrays, the system can shape and direct the radiation pattern of the transmitted or received signal. Beam steering can steer the main lobe of the radiation pattern in a particular direction.

Abstract: ROS-responsive prodrugs and methods of making thereof are disclosed. These prodrugs can contain two captopril moieties and one cinnamaldehyde moiety that are linked by a thioacetal linking moiety; upon cleavage of the thioacetal linking moiety by ROS, the prodrugs can release two captopril or captopril derivatives and one cinnamaldehyde or cinnamaldehyde derivative. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the prodrugs to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more additional anti-inflammatory active agents in their free form. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating an inflammatory disease or disorder, or treating or ameliorating one or more symptoms associated with an inflammatory disease or disorder in a subject are also disclosed.

Abstract: Provided is a system for drug delivery comprising a modified poly (amidoamine) (“PAMAM”) comprising a photo-cleavable compound bound to one or more active agents to form a nanocomplex. Also provided is a method of treating a subject comprising administering the PAMAM nanocomplex and irradiating the nanocomplex at the target site with a light source. In particular, the modified PAMAM is a DEACM-modified PAMAM or a BODIPY-modified PAMAM. Also provided is a method for screening for PAMAM-coumarin-active agent nanocomplexes.

Abstract: The field of various phototriggered drug release and photoreactions, including reactions generally based on triplet-triplet energy transfer with light excitation at long wavelengths. Systems and methods for absorbing energy in a photosensitizer, and methods for making or using such systems, kits including such systems. The systems and methods comprise transferring that energy by triplet-triplet energy transfer to cleave a cleavable or other active moiety, for instance, in order to cause the release of a releasable moiety. In some cases, these may be contained within a suitable carrier material, for example, a particle or a micelle. Such systems and methods may be used in a variety of applications, including various biological or physical applications. For example, such systems and methods may be useful for delivering drugs or other releasable moieties to regions of a subject.

Abstract: A detection device for fusion of tactile sensing and optical tomography includes a handheld probe, a controller for performing signal control and data acquisition on the handheld probe and communicating with a computer, and the computer for performing data analysis and image reconstruction and display on controller information. The handheld probe includes a probe front cover. A tactile sensor, a probe base, and a photoelectric sensor module disposed in sequence are sandwiched between a first probe side cover and a second probe side cover matching the probe front cover. An optical fiber connected to the photoelectric sensor module is interposed between the first probe side cover and the second probe side cover. A detection method based on the detection device comprises detecting tumors inside biological tissue, and detecting physical changes (i.e. local hardness) of the tissue and functional changes (i.e. blood supply distribution) of the tissue.

Abstract: An antenna element comprises one or more directors, a resonator, and a three dimensional ground assembly. Parts of the antenna element are arranged on three metal layers. A top layer has an unconnected metal bar which forms a beam director, a resonator and a top part of the ground assembly. The resonator is an integral piece substantially in the form of a loop connected to a feed line and a feed line terminal ending. The feed line terminal ending serves as the ground plane for the feed line as well as providing impedance matching from the external transceiver circuit to the resonator. The ground assembly includes a top layer ground connected to a plurality of metallized half cylindrical hole channels (or metallized via holes) which connect to a ground terminal in a bottom layer.

Abstract: A communication device comprising: a first unit having a first antenna, a second antenna, and a first signal transmitting and receiving circuitry; a second unit having a third antenna, a fourth antenna, and a second signal transmitting and receiving circuitry, wherein the second unit is located in proximity to the first unit; and wherein the second unit is capable of receiving signals at a first signal frequency, down converting the signals to a second signal frequency, and relaying the signals through a barrier to the first unit. Wherein the first signal frequency is in the millimeter wave range and the second signal frequency is in the microwave range.

Abstract: A communication device comprising: a first unit having a first antenna, a second antenna, and a first signal transmitting and receiving circuitry; a second unit having a third antenna and a fourth antenna and wherein the second unit is located in proximity to the first unit; wherein the second unit is capable of receiving a first radio frequency (RF) signal at a first frequency, amplifying the first RF signal in a second unit low noise amplifier (LNA), and autonomously transmitting the first RF signal through a barrier to the first unit; and wherein the first unit is capable of transmitting signals at the first frequency to a wireless device. The communication device is capable of operating in a first mode by communicating with a terrestrial base station and in a second mode with a satellite.

Abstract: An antenna element comprises one or more directors, a resonator, and a three dimensional ground assembly. Parts of the antenna element are arranged on three metal layers. A top layer has an unconnected metal bar which forms a beam director, a resonator and a top part of the ground assembly. The resonator is an integral piece substantially in the form of a loop connected to a feed line and a feed line terminal ending. The feed line terminal ending serves as the ground plane for the feed line as well as providing impedance matching from the external transceiver circuit to the resonator. The ground assembly includes a top layer ground connected to a plurality of metallized half cylindrical hole channels (or metallized via holes) which connect to a ground terminal in a bottom layer.

Abstract: A wireless hub includes a vehicle power connector that can draw power from a vehicle battery on a vehicle, a first wireless transmission circuit that can send or receive data with base stations in a long-range wireless network, a second wireless transmission circuit that can provide a short-range wireless network and to transfer data to and from electronic devices, and a network processor that can process data in the first wireless transmission circuit and the second wireless transmission circuit. The wireless hub has an antenna array for millimeter wave communications.

Abstract: A piston discharge structure for a plasma cloud excitation engine is provided. The piston discharge structure includes a movement electrode, a distributed multi-cavity combustion chamber, a fixed electrode, and a variable interval discharge region. The movement electrode is provided at a top portion of a piston and includes a first combination shape and a first movement electrode structure, the distributed multi-cavity combustion chamber is provided at the top portion of the piston, the fixed electrode is provided at a top portion of a cylinder block or a bottom portion of a cylinder head and including a second combination shape and a second structure, and the variable interval discharge region is defined by the movement electrode and the fixed electrode.