Abstract: A class of piperazine derivatives and application thereof, specifically compound represented by formula (III) or pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to operations that include determining, based on a first optical imaging result obtained using an optical imaging system, one or more biomechanical properties of a target tissue corresponding to an eye. The operations may further include determining, based on the first optical imaging result, one or more geometric properties of the target tissue. The operations may further include generating a customized treatment plan for treatment of the target tissue based on the one or more biomechanical properties and the one or more geometric properties.

Abstract: In various embodiments, a computer-implemented method for updating configurations of endpoint devices when streaming media titles includes receiving a first encoding derived from a first segment of audiovisual content in conjunction with receiving size data corresponding to one or more encodings of a second segment of audiovisual content, and updating a configuration of an endpoint device to cause the endpoint device to receive a second encoding derived from the second segment of audiovisual content based on the size data when streaming a media title.

Abstract: A system for guiding an ophthalmic procedure includes an optical coherence tomography (OCT) device configured to obtain respective data of a target site in an eye. The OCT device has a swept source laser tunable through a range of wavelengths. The OCT device includes a first imaging mode with a first imaging depth and a second imaging mode with a second imaging depth, the first imaging depth being greater than the second imaging depth. The controller is adapted to execute first and second sampling modules to process the respective OCT signal from the first and second imaging modes. The controller is adapted to generate an output signal indicative of at least one of pupil centering information and tilt angle of the target site based in part on the first dataset and the second dataset. The output signal is employed for pre-surgical alignment of the target site.

Abstract: Techniques for fine-tuning of Large Language Models are disclosed. A system receives a pre-trained Large Language Model (LLM) with a set of model parameters from data source. The system also obtains a supervised fine-tuning dataset corresponding to the received pre-trained LLM from the data source. Further, the system selects a grouping strategy for the determined supervised fine-tuning dataset and assigns an importance label to each token in the determined supervised fine-tuning dataset based on the selected grouping strategy. The system further computes a first loss value, a second loss value and a third loss value. The system computes a compute a group-optimization loss value as a weighted combination of the first loss value, the second loss value and the third loss value. Consequently, the system fine-tune the pre-trained LLM by updating the set of model parameters of the pre-trained LLM based on the group optimization loss value.

Abstract: Provided is a damping mesh, including at least two first wires and at least two second wires. Each first wire includes a first cylinder and at least one first protrusion formed on the first lateral surface of the first cylinder and extending away from the first lateral surface in a direction parallel to the second direction. Each second wire includes a second cylinder and at least one second protrusion formed on the second lateral surface of the second cylinder and extending away from the second lateral surface in a direction parallel to the first direction. After the first wires and the second wires are interlaced with each other, two opposite first protrusions of two adjacent first wires, and two opposite second protrusions of two adjacent second wires, cooperatively form a ventilation hole with a reduced area, which effectively improves the acoustic resistance.

Abstract: An image processing method includes determining, according to a position of a captured article, a three-dimensional area, a whole or a part of the captured article being located inside the three-dimensional area; arranging, on a surface of the three-dimensional area, a plurality of image capturing positions; and capturing a first image of the captured article at a viewing angle for each image capturing position of the plurality of image capturing positions by using an image capturing apparatus at the each image capturing position, to obtain a plurality of first images of the captured article at different viewing angles, and cause that an image display apparatus displays, according to the plurality of first images, an image corresponding to a selected viewing angle.

Abstract: Anti-CD3 antibodies for use in the diagnosis or treatment of hyperproliferative or autoimmune disorders methods of using the same for detecting and/or treating a hyperproliferative or autoimmune disorders.

Abstract: A method for assessing impacts of subsurface scale formation from fluid flow to improve hydrocarbon recovery from a fractured subterranean formation may include obtaining first measurements of a parameter associated with a first interaction between a first core sample and a first fluid, where the first fluid includes a first brine without a scale inducer. The method also includes establishing a baseline of the parameter using the first measurements. The method further includes obtaining second measurements of the parameter associated with a second interaction between a second core sample and a second fluid, and where the second fluid includes a second brine and a scale impact additive. The method also includes comparing the second measurements to the baseline and identifying a target fluid based on the comparison.

Abstract: A method for controlling a microgrid of a hydrometallurgical plant based on an energy storage frequency converter includes: controlling the opening and closing of a first circuit breaker and a second circuit breaker based on frequency change data of an AC bus in a plant microgrid. The energy storage frequency converter includes an energy storage unit, a first AC-DC converter, and an inverter. An input end of the first AC-DC converter is connected to an external power grid through an AC bus, and a first circuit breaker is provided between the first AC-DC converter and the external power grid. An input end of the inverter is connected to an output end of the first AC-DC converter, and an output end is connected to a variable frequency motor. The energy storage unit is connected between the output end of the first AC-DC converter.

Abstract: This disclosure relates to systems for wellbore drilling and methods for preparing wellbore drilling fluid. The system can include a drilling fluid tank that holds wellbore drilling fluid for introduction into a wellbore, an additive distribution component fluidly coupled to the drilling fluid tank that holds a first additive, and a computing device communicatively coupled to the additive distribution component. The methods can include a computing device performing at least the following: receiving drilling parameters that identify wellbore drilling conditions of a wellbore drilling system, calculating a thermochemical sulfate reduction (TSR) proxy value of the wellbore. In response to determining that a predicted hydrogen sulfide concentration meets a predetermined threshold, the computing device can determine a first quantity of a first additive to be added to the wellbore drilling fluid and combine the first quantity of the first additive with the wellbore drilling fluid.

Abstract: A semiconductor component includes a substrate, an epitaxial layer, a first dielectric layer, and a second dielectric layer that are sequentially stacked. The first dielectric layer may include a first material, and the second dielectric layer may include a second material. An element included in the first material may not be completely the same as an element included in the second material. The first material may include an aluminum element, and the second material may include a silicon element.

Abstract: A nanopreparation loaded with trabectedin and paclitaxel is provided. The nanopreparation loaded with trabectedin and paclitaxel includes a non-targeted drug-loaded micelle loaded with paclitaxel and a first targeting group linked to a first micelle carrier, where the non-targeted drug-loaded micelle has a first shell-core structure, and the first micelle carrier is prepared from poly(?-caprolactone)-poly(2-ethyl-2-oxazoline) (PCL-PEOz), where a hydrophobic block of PCL and paclitaxel jointly form a core of the first shell-core structure, and a hydrophilic block of PEOz forms a shell of the first shell-core structure; and the first targeting group is linked via an amide bond formed between —NH2 on a surface of the first targeting group and —COOH at a terminus of the PEOz on a surface of the shell.

Abstract: Certain embodiments of the present application relate to an unmanned aerial vehicle, comprising a chassis, a control system mounted to the chassis, at least one rotor operable to generate lift under control of the control system, a spool having a wound portion of a line wound thereon, the line including a free portion, an attachment device secured to the free portion of the line and configured to facilitate attachment of a parcel to the line, a motor operable to rotate the spool under control of the control system such that the control system is operable to raise the attachment device to a raised position and lower the attachment device from the raised position, and a spring positioned between the chassis and the attachment device such that the spring is engaged between the chassis and the attachment device when the attachment device is in the raised position.

Abstract: A method for controlling a surface temperature of a power-consuming device. The method comprises obtaining a historical temperature of at least one heat emitting part located inside or outside, or both, the power-consuming device. The historical temperature is between a first moment and a second moment. The method further comprises using the historical temperature as an input of a temperature prediction model, and outputting a predicted temperature of an external surface of the power-consuming device at a third moment after the first moment and the second moment. The temperature prediction model represents a relationship between the historical temperature and the predicted temperature. The method further comprises adjusting a working status of the power-consuming device based on the predicted temperature, to control the external surface temperature of the power-consuming device.

Abstract: Embodiments disclosed herein include package substrates with bridge dies. In an embodiment, an apparatus comprises a first layer that is a glass layer. A via is provided through the first layer, where the via is electrically conductive. In an embodiment, a second layer is over the first layer, and the second layer comprises an organic dielectric material. In an embodiment, a cavity is provided in the second layer, where the via is within a footprint of the cavity. In an embodiment, a die is in the cavity. In an embodiment, the die is electrically coupled to the via.

Abstract: This application provides an adsorber, including: a housing with a cavity therein; a plurality of spaced adsorption bed layers and airflow distribution plates, located in the cavity; where air inlets of the housing are configured to respectively inject a gas to be adsorbed and a regeneration gas into the cavity, and air outlets of the housing are configured to discharge an adsorbed gas and a desorbed gas; interval between two adjacent adsorption bed layers constitutes a channel, and the channel is respectively communicated with the air inlet and the air outlet, with a width of the channel gradually decreasing along a direction from the air inlet toward the air outlet; inlets of the airflow distribution plates are communicated with the air inlets, and outlets of the airflow distribution plate face the adsorption bed layers; and the airflow distribution plate has gradually decreasing aperture diameters from the inlets to the outlets.

Abstract: A system for purifying helium gas, a method, and an application. The system includes a first gas-liquid separation device, a primary helium extraction tower, a second gas-liquid separation device, a secondary helium extraction tower, and a nitrogen removal tower, which are in sequential communication. The first gas-liquid separation device performs first treatment to convert helium-containing natural gas into a first gas and first liquid phases; the primary helium extraction tower performs first distillation on the first gas and first liquid phases to obtain a second gas and second liquid phases; the second gas-liquid separation device performs second treatment to convert the second gas phase to a third gas and third liquid phase; the secondary helium extraction tower performs second distillation on the third gas and third liquid phases to obtain crude helium and a fourth liquid phase form which nitrogen is removed by the nitrogen removal tower.