Abstract: A method, computer system, and a computer program product for detecting a session status based on a cookie associated with the session is provided. The present invention may include receiving an access request to a specified location associated with a server computer. The present invention may also include determining that the received access request has the cookie corresponding with the specified location. The present invention may also include receiving a last refresh time from the cookie. The present invention may then include determining the session status based on the retrieved last refresh time, a current request time, a refresh interval, and an overdue value.

Abstract: Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by administering the effector T cells and/or NK cells provided herein.

Abstract: A manufacturing method of a semiconductor device including the following steps is provided. A substrate having a device structure and a first interconnection structure on a front side is provided. A first annealing process is performed in an atmosphere of pure hydrogen at a first temperature. A second interconnection structure is formed on a back side of the substrate. A second annealing process is performed in an atmosphere of gas mixture including hydrogen at a second temperature.

Abstract: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.

Abstract: Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (DA) neurons using a mono-SMAD inhibition or inhibition of SMAD signaling with only one SMAD inhibitor. In some embodiments, mono-SMAD inhibition utilizes a single inhibitor of bone morphogenic protein (BMP) for differentiating pluripotent cells into midbrain DA neurons.

Abstract: A wafer level packaging method includes the following steps. A first wafer is bonded over a second wafer. A first grinding process on the first wafer is performed, to remove an upper chamfered edge of the first wafer and reduce a thickness of the first wafer. A trimming process is performed on the first wafer, to remove a lower chamfered edge of the first wafer to form a trimmed first wafer. A second grinding process is performed on the trimmed first wafer, to reduce a thickness of the trimmed first wafer.

Abstract: The present invention discloses a method of producing drimenol and/or drimenol derivatives by contacting a polypeptide with farnesyl pyrophosphate. Also provided is an amino acid sequence of a polypeptide useful in the methods of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.

Abstract: A flexible liquid level sensing device includes a sensing module having a circuit board and a plurality of sensing elements. The coupled assembly includes a plurality of joining pipes connected in series. Each joining pipe includes a sleeve portion and a rotary head. The rotary head of one joining pipe is inserted into and rotatably coupled to the sleeve portion of an adjacent joining pipe. The coupled assembly forms an accommodating space for receiving the sensing module.

Abstract: A manufacturing method of a semiconductor device including the following steps is provided. A substrate having a device structure and a first interconnection structure on a front side is provided. A first annealing process is performed in an atmosphere of pure hydrogen at a first temperature. A second interconnection structure is formed on a back side of the substrate. A second annealing process is performed in an atmosphere of gas mixture including hydrogen at a second temperature.

Abstract: A method for controlling a pipeline-based processor. The method includes determining a change in a workload. The method also includes activating or shutting down, by at least one controller circuit, one or more of the plurality of enhanced pipeline stages based on at least one corresponding enhanced stage priority level of the one or more of the plurality of enhanced pipeline stages and requirements for performance of the workload. The method additionally includes activating or shutting down, by the at least one controller circuit, one or more of the plurality of enhanced modules of the particular pipeline stage based on at least one corresponding priority level of the one or more of the plurality of enhanced modules of the particular pipeline stage and the requirements for the performance of the workload.

Abstract: The invention described herein provides high throughput methods and reagents for generating transgenic animals (e.g., non-human mammals) through introducing a CRISPR/Cas9 system comprising a Cas9 protein into gametes or preimplantation stage embryos (e.g., one-cell embryos or zygotes) via multiple cycles (e.g., 4-10 cycles) of electroporation, leading to genetically inheritable modification to the genome of the animal.

Abstract: The present invention discloses a method of producing drimenol and/or drimenol derivatives by contacting a polypeptide with farnesyl pyrophosphate. Also provided is an amino acid sequence of a polypeptide useful in the methods of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.

Abstract: A method, computer system, and a computer program product for detecting a session status based on a cookie associated with the session is provided. The present invention may include receiving an access request to a specified location associated with a server computer. The present invention may also include determining that the received access request has the cookie corresponding with the specified location. The present invention may also include receiving a last refresh time from the cookie. The present invention may then include determining the session status based on the retrieved last refresh time, a current request time, a refresh interval, and an overdue value.

Abstract: A connecting device able to allocate master and slave roles between two intelligent devices having On-The-Go functions, depending on the intelligent device connects at a first point in time to one of two connectors, the connecting device also includes a control circuit connected between the two connectors. The control circuit between the connectors maintains and controls the master-slave relationship between the two intelligent devices.

Abstract: A wafer level packaging method includes the following steps. A first wafer is bonded over a second wafer. A first grinding process on the first wafer is performed, to remove an upper chamfered edge of the first wafer and reduce a thickness of the first wafer. A trimming process is performed on the first wafer, to remove a lower chamfered edge of the first wafer to form a trimmed first wafer. A second grinding process is performed on the trimmed first wafer, to reduce a thickness of the trimmed first wafer.

Abstract: A method, computer system, and a computer program product for detecting a session status based on a cookie associated with the session is provided. The present invention may include receiving an access request to a specified location associated with a server computer. The present invention may also include determining that the received access request has the cookie corresponding with the specified location. The present invention may also include receiving a last refresh time from the cookie. The present invention may then include determining the session status based on the retrieved last refresh time, a current request time, a refresh interval, and an overdue value.

Abstract: Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.

Abstract: A method, computer system, and a computer program product for detecting a session status based on a cookie associated with the session is provided. The present invention may include receiving an access request to a specified location associated with a server computer. The present invention may also include determining that the received access request has the cookie corresponding with the specified location. The present invention may also include receiving a last refresh time from the cookie. The present invention may then include determining the session status based on the retrieved last refresh time, a current request time, a refresh interval, and an overdue value.

Abstract: A 3-dimensional high-speed track car toy comprises a track body and a toy car. Straight tracks, curved tracks, centripetal tracks and centrifugal tracks are assembled to form a 3-dimensional closed track. The track body stands on the ground fixedly through support rods and support seats. The track body is paved with a track along which the toy car runs. Components of the track body have fastener-containing groove structures to fix an iron axis onto the track. The toy car is placed on the track body. The track is equipped with an iron axis. The bottom of the toy car is equipped with magnets. Thereby, a sufficient attractive force is generated to overcome gravity of the toy car. Therefore, the toy car can run on the track disposed on a ceiling or a vertical wall. Thus, the user can enjoy more amusement from playing the present invention.

Abstract: A connecting device able to allocate master and slave roles between two intelligent devices having On-The-Go functions, depending on the intelligent device connects at a first point in time to one of two connectors, the connecting device also includes a control circuit connected between the two connectors. The control circuit between the connectors maintains and controls the master-slave relationship between the two intelligent devices.