Abstract: A multi-shot moulding part structure includes a first structural part, an ink decoration layer, and a second structural part. The first structural part has a first area surface, a second area surface, and a joining surface located on the second area surface. The joining surface is non-parallel to the second area surface. The ink decoration layer is spread on the first area surface and the second area surface, but not on the joining surface. The second structural part is combined with the first structural part and covers the second area surface. The second structural part touches the joining surface. By the second structural part touching the joining surface of the first structural part that is not coated with the ink decoration layer, the structural bonding strength between the first structural part and the second structural part is enhanced.

Abstract: The present disclosure provides a semiconductor device and a method of manufacturing the semiconductor device. The semiconductor device includes channel members disposed over a substrate, a gate structure engaging the channel members, and an epitaxial feature adjacent the channel members. At least one of the channel members has an end portion in physical contact with an outer portion of the epitaxial feature. The end portion of the at least one of the channel members includes a first dopant of a first concentration. The outer portion of the epitaxial feature includes a second dopant of a second concentration. The first concentration is higher than the second concentration.

Abstract: The present disclosure provides a method for evaluating prognosis in a patient with breast cancer, including the following steps: (a) detecting the expression level of pyruvate kinase in a sample from the patient; (b) detecting the expression level of O-linked ?-N-acetylglucosamine in the sample; and (c) evaluating a clinical treatment score post-5 years, wherein high expression levels of both the pyruvate kinase and the O-GlcNAc, and high score of the CTS5 indicate that the patient has a poor prognosis. The present disclosure also provides a kit for evaluating prognosis in a patient with breast cancer.

Abstract: A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.

Abstract: Provided is a method of inhibiting tumor progression in a subject suffering from gastric cancer, including administering to said subject a pharmaceutical composition including an inhibitor of targeting PHF8-c-Jun-PKC?-Src-PTEN axis, or a pharmaceutically acceptable salt thereof. A method of determining a tumor progression state in a subject suffering from gastric cancer is also provided, which comprises providing a sample from the subject; detecting PHF8 expression level in the sample from the subject; and determining the tumor progression state of gastric cancer by the PHF8 expression level, wherein the PHF8 expression level is positively detected from moderate to strong expression indicating the subject suffering a late stage of gastric cancer.

Abstract: The present invention relates to a method for inhibiting activity of a protein selected from the group consisting of KDM4A, KDM4B, and KDM4C, comprising the step of exposing the protein to an effective inhibiting amount of a compound having the formula wherein R1 is H or C7O5H8; R2 is H, OH, or OCH3; and R3 is H or OH. The present invention also relates to a method for treating or lessening the severity of a disease, condition, or disorder in which modulation of KDM4A, KDM4B, or KDM4C is beneficial, which method comprises administering to a subject suffering from said disease, condition, or disorder a therapeutically-effective amount of: a) a compound having the formula wherein R1 is H or C7O5H8; R2 is H, OH, or OCH3; and R3 is H or OH; or b) a composition comprising the compound and a pharmaceutically acceptable adjuvant, vehicle, or carrier.

Abstract: A method for identifying a compound that inhibits an activity of a histone lysine demethylase, in which the compound interacts with three sites of a pocket of the histone lysine demethylase generated by using a computer program, an alpha-ketoglutarate (AKG), a methylated lysine, and a NIQ.

Abstract: The present invention relates to a method for identifying a compound that inhibits an activity of a histone lysine demethylase.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to a method for identifying a compound that inhibits an activity of a histone lysine demethylase.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: An exercise-cord anchored device is used to detachably secure an anchoring end of an elastic cord, and includes an anchored mount, a biasing member, and a tubular insert. The anchored mount has an inner tubular wall defining an insert opening and having an inserting route, a seat, and a rest wall. The biasing member is disposed in the insert opening. The tubular insert is coupled to the elastic cord, is insertable into the insert opening and is manually movable against the biasing force of the biasing member, and has a protuberance configured to be guided along the inserting route. When the mounting end is pushed manually to permit the protuberance to extend beyond the seat, the protuberance is turned angularly over the seat so as to abut against the rest wall, thereby retaining the tubular insert to the anchored mount.

Abstract: An exercise-cord anchored device is used to detachably secure an anchoring end of an elastic cord, and includes an anchored mount, a biasing member, and a tubular insert. The anchored mount has an inner tubular wall defining an insert opening and having an inserting route, a seat, and a rest wall. The biasing member is disposed in the insert opening. The tubular insert is coupled to the elastic cord, is insertable into the insert opening and is manually movable against the biasing force of the biasing member, and has a protuberance configured to be guided along the inserting route. When the mounting end is pushed manually to permit the protuberance to extend beyond the seat, the protuberance is turned angularly over the seat so as to abut against the rest wall, thereby retaining the tubular insert to the anchored mount.

Abstract: A method of identifying a drug candidate to a target protein for inhibiting shikimate pathway comprising (a) performing a molecular program for computing a molecule conformation and orientation relative to an active site of the target protein and selecting top-rank molecules, (b) generating protein-molecule interacting profiles and identifying conserved interactions and pharmacophore spots, (c) developing homologous pharmacophore models for identifying pharmacophore hot spots, (d) rescoring molecules selected from step (a) by their homologous pharmacophore scores, (e) selecting potential molecules having the highest homologous pharmacophore scores, and (f) acquiring corresponding real compounds of the potential molecules selected from step (c) and identifying their inhibitory activity on the target protein by bioassay.

Abstract: A pull cord assembly for body stretching exercise includes an elastic cord member and a strand-like protective member. The elastic cord member has an elastic cord body which extends along a lengthwise axis to terminate at two anchored ends. The strand-like protective member has a strand-like body which extends lengthwise to terminate at two coupled ends that are secured with the anchored ends, respectively. The strand-like body is twined around the elastic cord body along the lengthwise axis so as to enhance the safety of using the pull cord assembly.

Abstract: The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds, which is an attractive target for the rational drug and herbicide design because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals. Thus, the present invention provides a method of inhibiting the growth of bacteria or fungi, especially Helicobacter pylori, through inhibiting enzymes in the shikimate pathway.

Abstract: A safety elastic rope includes an elastic outer tubular rope having two longitudinally opposite first fixing ends, and an elastic inner rope inserted into the outer tubular rope and having two longitudinally opposite second fixing ends. The inner rope is more elastic than the outer tubular rope, and has substantially the same length as the outer tubular rope. The second fixing ends are connected respectively to the first fixing ends.

Abstract: A pull cord assembly for body stretching exercise includes an elastic cord member and a strand-like protective member. The elastic cord member has an elastic cord body which extends along a lengthwise axis to terminate at two anchored ends. The strand-like protective member has a strand-like body which extends lengthwise to terminate at two coupled ends that are secured with the anchored ends, respectively. The strand-like body is twined around the elastic cord body along the lengthwise axis so as to enhance the safety of using the pull cord assembly.