Abstract: An organization-specific cybersecurity dialogue system (“system”) intelligently generates responses to user utterances for cybersecurity by employing documentation and playbook agents for an associated cybersecurity organization. The system extracts an intent and an intent category from a user utterance, extracts relevant entities from the intent and uses them to determine relevant user telemetry data, and matches the intent, intent category, and user telemetry data to documents of the cybersecurity organization. The system then determines whether to generate a response based on matching document, matching playbook agents, or to prompt a user to create a ticket according to logic applied to the intent, intent category, user telemetry data, and matching documents and generates a corresponding response with large language models.

Abstract: A method for designing a metalens used for an image sensor and an image sensor is provided, the method includes: S1. determining a target waveband; S2. according to the target waveband, determining an initial structure parameter and an initial material parameter of the unit cells; S3. optimizing the initial structure parameters of the unit cells and the initial material parameters of the unit cells, so as to obtain target parameters of unit cells; the target parameters of unit cells comprise: a phase of the unit cells and transmittance of the unit cells for an oblique incident light; S4: determining whether the transmittance of the metalens with the target structure parameter of unit cells meets the target transmittance.

Abstract: A method, computer program product, and computing system for processing a plurality of log files from one or more storage systems. A log pattern concerning at least two or more log files is identified by processing each log file from the plurality of log files using one or more processing threads. A potential overlogging issue associated with the log pattern is identified.

Abstract: Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a tricyclic heteroaryl group substituted with R3a and zero to 2 R3b; and R1, R2, R3a, R3b, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Abstract: Techniques for processing read/write requests involve determining an average response time for read/write requests to a storage device within a predetermined time period, and comparing the average response time with at least one predetermined threshold. Such techniques further involve adjusting a read/write request upper limit of the storage device based on the comparison between the average response time and the at least one predetermined threshold. Here, the read/write request upper limit indicates the maximum number of read/write requests in a read/write request queue for the storage device. In this way, the read/write request upper limit of a storage device may be dynamically adjusted based on a current response time of the storage device for processing read/write requests, and slow read/write processing caused by the accumulation of read/write requests at one storage device can be avoided.

Abstract: An exemplary system according to the present disclosure comprises a computing device that in operation, causes the system to receive financial product or financial portfolio data, map the financial product to a risk factor, execute a risk factor simulation process involving the risk factor, generate product profit and loss values for the financial product or portfolio profit and loss values for the financial portfolio based on the risk factor simulation process, and determine an initial margin for the financial product. The risk factor simulation process can be a filtered historical simulation process.

Abstract: The innate immune sensing STING pathway has emerged as a potential therapeutic target to boost antitumor immune responses. STING resides in the cytoplasm, and its agonists, such as cGAMP, are dinucleotides that are difficult to deliver intracellularly. Disclosed herein is a microbubble-based platform (Microbubble (MB)-assisted UltraSound (US)-guided Immunotherapy of Cancer (MUSIC)) that can be used for targeted activation of STING, such as for treatment of primary and metastatic tumors.

Abstract: The present disclosure provides systems and methods for robotic navigation, teaching, and mapping. In some cases, the robotic systems and methods may be used to clean an area or environment.

Abstract: An exemplary system according to the present disclosure comprises a computing device that in operation, causes the system to receive financial product or financial portfolio data, map the financial product to a risk factor, execute a risk factor simulation process involving the risk factor, generate product profit and loss values for the financial product or portfolio profit and loss values for the financial portfolio based on the risk factor simulation process, and determine an initial margin for the financial product. The risk factor simulation process can be a filtered historical simulation process.

Abstract: Presented herein is a stage area for “focused” video that is configured to allow for dynamic layout changes during an online video conference or meeting. By providing a user interface environment that allows a user (meeting participant) to customize the stage, each participant can choose their own view, and the meeting host can fully customize a view for every participant in the meeting.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Abstract: Disclosed are a cathode active material for sodium-ion batteries and a preparation method therefor and an application thereof. The cathode active material has a chemical formula of NaxNiyFezMngMhAmO2, where M is selected from the group consisting of Ti, Al, Mg, Ca, Zr, Y, Zn, Nb, W and combinations thereof, A is selected from the group consisting of B, P, C and combinations thereof, 0.80?x?1.40, 0.05?y?0.95, 0.05?z?0.95, 0.05?g?0.95, 0.01?h?0.50, and 0.01?m?0.30. By adding M and A elements to the ternary iron-manganese-nickel cathode active material for sodium-ion batteries, and controlling the ratio of all elements, the present disclosure can achieve the formation of a perfect layered single-crystal structure of the cathode active material for sodium-ion batteries, with large particles, ultimately achieving the stability of the active material, and when used in sodium-ion batteries, it can significantly improve the cycling performance at high temperatures while ensuring high gram capacity.

Abstract: A bicyclic substituted aromatic carboxylic acid compound, in particular a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. In formula (I), R2 and R3 and atoms connected thereto together form a 3-6 membered heterocyclic group, or R2 and R4 and atoms connected thereto together form a 3-6 membered heterocyclic group. The compound has obvious inhibitory activity on activation of a human serum alternative pathway and significant binding activity to human complement Factor B protein, and also has relatively good in-vivo pharmacodynamic and pharmacokinetic properties.

Abstract: In a method of coating a photo resist over a wafer, dispensing the photo resist from a nozzle over the wafer is started while rotating the wafer, and dispensing the photo resist is stopped while rotating the wafer. After starting and before stopping the dispensing the photo resist, a wafer rotation speed is changed at least 4 times. During dispensing, an arm holding the nozzle may move horizontally. A tip end of the nozzle may be located at a height of 2.5 mm to 3.5 mm from the wafer.

Abstract: A method for manufacturing a semiconductor device includes forming a forming a photoresist layer over a semiconductor substrate and selectively exposing the photoresist layer to actinic radiation. After selectively exposing the photoresist layer to actinic radiation, storing the semiconductor substrate in a semiconductor substrate container under an ambient of extreme dry clean air or inert gas. The method also includes after the storing the semiconductor substrate, performing a first heating of the photoresist layer.

Abstract: Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.

Abstract: An exemplary system according to the present disclosure comprises a computing device that in operation, causes the system to receive financial product or financial portfolio data, map the financial product to a risk factor, execute a risk factor simulation process involving the risk factor, generate product profit and loss values for the financial product or portfolio profit and loss values for the financial portfolio based on the risk factor simulation process, and determine an initial margin for the financial product. The risk factor simulation process can be a filtered historical simulation process.

Abstract: Disclosed are a cathode active material for sodium-ion batteries and a preparation method therefor and an application thereof. The cathode active material has a chemical formula of NaxNiyFezMngMhAmO2, where M is selected from the group consisting of Ti, Al, Mg, Ca, Zr, Y, Zn, Nb, W and combinations thereof, A is selected from the group consisting of B, P, C and combinations thereof, 0.80?x?1.40, 0.05?y?0.95, 0.05?z?0.95, 0.05?g?0.95, 0.01?h?0.50, and 0.01?m?0.30. By adding M and A elements to the ternary iron-manganese-nickel cathode active material for sodium-ion batteries, and controlling the ratio of all elements, the present disclosure can achieve the formation of a perfect layered single-crystal structure of the cathode active material for sodium-ion batteries, with large particles, ultimately achieving the stability of the active material, and when used in sodium-ion batteries, it can significantly improve the cycling performance at high temperatures while ensuring high gram capacity.