Patents by Inventor Wen-Liang Chang

Wen-Liang Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120189719
    Abstract: Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.
    Type: Application
    Filed: November 17, 2011
    Publication date: July 26, 2012
    Applicant: NATIONAL DEFENSE MEDICAL CENTER
    Inventors: WEN-LIANG CHANG, CHEN-WEN YAO, CHI-HONG CHU, AN-RONG LEE, ANN CHEN, WEN-HSIN HUANG, KUO-YUAN HWA, CHIAO-YING CHIEN, CHIEN-YI PAI
  • Patent number: 8197860
    Abstract: The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: June 12, 2012
    Assignee: Nuliv Holding Inc.
    Inventors: Hang-Ching Lin, Wen-Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Patent number: 8168596
    Abstract: A method of treating a disease associated with cartilage defect in a subject in need thereof by administering to the subject an effectively amount of a cycloartane compound of Formula (I).
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: May 1, 2012
    Assignee: NuLiv Holding Inc.
    Inventors: Wen-Liang Chang, Tsu-Chung Chang, Hang-Ching Lin, Yuan Yang, Shu-Fen Huang
  • Publication number: 20120101157
    Abstract: Disclosed are 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives and manufactures thereof. The 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives are presented by formula (I): wherein R1 group is H, CH3, or C2H5; R2 group is H, or Br; R3 group is CH3, or C3H7; and R4 group is H, or C(?NH)—NH2. 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives provided here were non-toxic to MDCK cells, particularly compounds 6a, 6b, 6c, 6e, 6f, 7a, 7b and 8 had better anti-H1N1 activity. In the future, these compounds can be used to focus on viral neuraminidases as targets to develop effective anti-influenza drugs.
    Type: Application
    Filed: October 24, 2011
    Publication date: April 26, 2012
    Applicant: NATIONAL DEFENSE MEDICAL CENTER
    Inventors: AN-RONG LEE, WEN-HSIN HUANG, CHI-HONG CHU, WEN-LIANG CHANG, CHEN-WEN YAO, I-LING CHEN
  • Patent number: 7959952
    Abstract: A method for skin care includes administering the water insoluble fraction of Astragalus membranaceus, or astragaloside compounds thereof to a subject in need thereof at an effective amount for improving skin texture, reducing wrinkles, UV protection, and/or providing an anti-aging effect.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: June 14, 2011
    Assignee: Nuliv Holding Inc.
    Inventors: Wen-Liang Chang, Tsu-Chung Chang, Hang-Ching Lin, Yuan Yang
  • Publication number: 20110053899
    Abstract: A pharmaceutical composition for treating diabetes is provided in this invention. The composition contains a lanostane compound as a potent component. A suitable source of the lanostane compound is a Poria extract from metabolite, sclerotium, or fermentation product of Poria cocos (Schw) Wolf. The Poria extract contains 1-60% of the lanostane compounds by weight of the extract, and is devoid of secolanostane.
    Type: Application
    Filed: August 10, 2010
    Publication date: March 3, 2011
    Applicant: SINPHAR TIAN-LI PHARMACEUTICAL CO., LTD (HANGZHOU)
    Inventors: Hang-Ching Lin, Yu-Chuan Huang, Tsu-Chung Chang, Wen-Liang Chang
  • Publication number: 20100298283
    Abstract: A pharmaceutical composition is used to enhance immunity of the human body. The composition contains potent components of lanostane compounds. A method is devised to obtain an extract from metabolite, sclerotium, or fermentation product of Poria cocos (Schw) Wolf. The extract contains 5-60% of the lanostane compounds by weight of the extract. The extract is devoid of secolanostane capable of inhibiting immunity development.
    Type: Application
    Filed: July 19, 2010
    Publication date: November 25, 2010
    Applicant: Sinphar Pharmaceutical Co., Ltd.
    Inventors: Hang-Ching Lin, Jerming Tseng, Hsiou-Yu Ding, Wen-Liang Chang, Chien-Lian Chao, Hsin-Wen Huang
  • Patent number: 7714026
    Abstract: The present invention discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering osteoporosis. An embodiment of this novel use is a pharmaceutical composition containing bakuchiol or an extract containing bakuchiol, which can be in the dosage forms of topical use, oral administration, injection or sustained release. The present invention also discloses a novel use of bakuchiol or an extract containing bakuchiol in preventing or treating a woman suffering breast cancer.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: May 11, 2010
    Assignee: Sinphar Pharmaceutical Co., Ltd.
    Inventors: Hang-Ching Lin, Hsiou-Yu Ding, Wen-Liang Chang, Chien-Lian Chao, Hsin-Wen Huang, Chin-Liang Lin
  • Publication number: 20100099637
    Abstract: A method of treating a disease associated with cartilage defect in a subject in need thereof by administering to the subject an effectively amount of a cycloartane compound of Formula (I).
    Type: Application
    Filed: October 17, 2008
    Publication date: April 22, 2010
    Applicant: NULIV HOLDING INC.
    Inventors: WEN-LIANG CHANG, TSU-CHUNG CHANG, HANG-CHING LIN, YUAN YANG, SHU-FEN HUANG
  • Publication number: 20100099633
    Abstract: The present application relates to a method for enhancing absorption of a nutrient in a subject in need thereof with an effective amount of an isolated astragaloside compound.
    Type: Application
    Filed: April 15, 2009
    Publication date: April 22, 2010
    Applicant: NuLiv Holding Inc.
    Inventors: Hang-Ching Lin, Wen-Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Publication number: 20090247496
    Abstract: The present invention discloses a novel use of a lanostane having the following formula (I) in enhancing uptake of nutrients: wherein R1 is either H or CH3; R2 is OCOCH3, ?O or OH; R3 is H or OH; R4 is —C(?CH2)—C(CH3)2Ra, in which Ra is H or OH, or —CH?C(CH3)—Rb, in which Rb is CH3 or CH2OH; R5 is H or OH; and R6 is CH3 or CH2OH.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 1, 2009
    Applicant: Sinphar Pharmaceutical Co., Ltd.
    Inventors: Hang-Ching Lin, Tsu-Chung Chang, Wen-Liang Chang, Yi-Yang Song
  • Publication number: 20090181904
    Abstract: The present application relates to a method of regulating nutrient absorption in a subject in need thereof with an isolated ginsenoside compound.
    Type: Application
    Filed: December 29, 2008
    Publication date: July 16, 2009
    Applicant: NULIV HOLDING INC.
    Inventors: Hang-Ching Lin, Wen- Liang Chang, Tsu-Chung Chang, Hsiou-Yu Ding, Tian Shung Wu
  • Publication number: 20090111870
    Abstract: An acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, are administered alone or in combination with one or more chemotherapy drugs and are effective in treating cancers.
    Type: Application
    Filed: October 29, 2008
    Publication date: April 30, 2009
    Applicant: BUDDHIST TZU CHI GENERAL HOSPITAL
    Inventors: Jiann-Kuan Luo, Horng-Jyh Harn, Wen-Liang Chang, Shinn-Zong Lin, Yeung-Leung Cheng, Nu-Man Tsai
  • Patent number: 7455861
    Abstract: The invention provides an acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, which are effective in treating cancers.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: November 25, 2008
    Assignee: Buddhist Tzu Chi General Hospital
    Inventors: Jiann-Kuan Luo, Horng-Jyh Harn, Wen-Liang Chang, Shinn-Zong Lin, Yeung-Leung Cheng, Nu-Man Tsai
  • Publication number: 20080152735
    Abstract: The invention provides a herbal extract having anti-influenza virus activity, by extracting Sophora flavescens Ait, Thesium chinense Turcz, licorice, or mixture thereof with solvent.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 26, 2008
    Applicant: NATIONAL DEFENSE MEDICAL CENTER
    Inventors: Wen-Liang Chang, Chen-Wen Yao, Ann Chen, Chung-Yang Yen, Li-Shian Shi, Jenn-Han Chen, Ching-Len Liao, Kuo-Yuan Hwa, An-Rong Lee, Po-Huang Liang
  • Publication number: 20080057010
    Abstract: The present invention provides a method for skin care comprising administering an the water insoluble fraction of Astragalus membranaceus, or astragaloside compounds to a subject in need thereof at an effective amount for improving skin texture, reducing wrinkles, UV protection, and anti-aging effect.
    Type: Application
    Filed: September 1, 2006
    Publication date: March 6, 2008
    Applicant: NULIV SCIENCE LTD.
    Inventors: Wen-Liang Chang, Tsu-Chung Chang, Hang-Ching Lin, Yuan Yang
  • Publication number: 20070254290
    Abstract: This invention discloses a method for diagnosing Crescentic glomerulonephritis (CRGN) using at least a sample from a patient. The method is to find a least one biomarker for diagnosing Crescentic glomerulonephritis. The genetic performance of Sparc, Lcn2 and/or Spp1 can be used as biomarkers.
    Type: Application
    Filed: November 8, 2006
    Publication date: November 1, 2007
    Inventors: Chung-Yang Yen, Ann Chen, Ching-Len Liao, Jenn-Han Chen, Wen-Liang Chang, Chen-Wen Yao, Kuo-Yuan Hwa
  • Publication number: 20070154897
    Abstract: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
    Type: Application
    Filed: April 20, 2006
    Publication date: July 5, 2007
    Applicant: National Defense Medical Center
    Inventors: Chung-Yang Yen, Ching-Len Liao, Jenn-Han Chen, Wen-Liang Chang, Ann Chen, Kuo-Yuan Hwa, Chen-Wen Yao, Chao-Wen Cheng, Shun-Min Yang
  • Publication number: 20070134351
    Abstract: The invention provides an acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, which are effective in treating cancers.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 14, 2007
    Applicant: BUDDHIST TZU CHI GENERAL HOSPITAL
    Inventors: Jiann-Kuan LUO, Horng-Jyh HARN, Wen-Liang CHANG, Shinn-Zong LIN, Yeung-Leung CHENG, Nu-Man TSAI
  • Publication number: 20060293255
    Abstract: There is provided a method for regulating the absorption of a nutrient in a subject, including administering to the subject an effective amount of a ginsenoside compound purified from Panax notoginseng for modulating transportation of the nutrient across gut cells of the subject.
    Type: Application
    Filed: June 23, 2006
    Publication date: December 28, 2006
    Applicant: NULIV SCIENCE INC. - A TAIWAN, R.O.C. CORPORATION
    Inventors: Hang-Ching LIN, Wen-Liang CHANG, Tsu-Chung CHANG, Hsiou-Yu DING, Tian WU