Patents by Inventor Wen Ling

Wen Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12630626
    Abstract: Provided are an anti-CLDN18.2 antibody or antigen-binding fragment thereof, a nucleic acid molecule encoding the same, an immunoconjugate, bispecific molecule, chimeric antigen receptor and pharmaceutical composition comprising the same. The antibody or antigen-binding fragment thereof is used for preventing and/or treating a tumor.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: May 19, 2026
    Assignee: SHANGHAI GENBASE BIOTECHNOLOGY CO., LTD.
    Inventors: Liang Du, Hongyan Zhang, Wen Ling, Jijun Yuan
  • Publication number: 20210403552
    Abstract: Provided are an anti-CLDN18.2 antibody or antigen-binding fragment thereof, a nucleic acid molecule encoding the same, an immunoconjugate, bispecific molecule, chimeric antigen receptor and pharmaceutical composition comprising the same. The antibody or antigen-binding fragment thereof is used for preventing and/or treating a tumor.
    Type: Application
    Filed: October 22, 2018
    Publication date: December 30, 2021
    Inventors: Liang Du, Hongyan Zhang, Wen Ling, Jijun Yuan
  • Patent number: 11071470
    Abstract: A method of measuring a tissue parameter such as proteoglycan content and other relevant tissue parameters, e.g. tissue pH, in a tissue or an organ of a subject includes generating first and second frequency magnetic resonance data using T1? scans at different frequencies, wherein the frequencies are symmetric. The method also includes combining the first frequency magnetic resonance data and the second frequency magnetic resonance data to remove a number of contributions from a number of relaxation mechanisms other than chemical exchange, thereby obtaining chemical exchange-specific magnetic resonance data indicative of the tissue parameter in the tissue or the organ. The chemical exchange-specific magnetic resonance data may be used to measure the proteoglycan content in the tissue or organ.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: July 27, 2021
    Assignee: University of Pittsburgh—Of the Commonvvealth System of Higher Education
    Inventors: Wen Ling, Tao Jin, Kyongtae Ty Bae
  • Publication number: 20190159697
    Abstract: An exemplary methodology, procedure, system, method and computer-accessible medium can be provided to determine one or more particular frequencies of cross-relaxation between at least one molecule and at least one particular compound determine a chemical exchange based on magnetic resonance data using a further frequency which is different from the one or more particular frequencies, and derive particular information about the anatomical region of interest based on the chemical exchange.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 30, 2019
    Inventors: Wen LING, Minneapolis R. REGATTE, Gil NAVON, Alexej JERSCHOW
  • Publication number: 20170202477
    Abstract: A method of measuring a tissue parameter such as proteoglycan content and other relevant tissue parameters, e.g. tissue pH, in a tissue or an organ of a subject includes generating first and second frequency magnetic resonance data using T1? scans at different frequencies, wherein the frequencies are symmetric. The method also includes combining the first frequency magnetic resonance data and the second frequency magnetic resonance data to remove a number of contributions from a number of relaxation mechanisms other than chemical exchange, thereby obtaining chemical exchange-specific magnetic resonance data indicative of the tissue parameter in the tissue or the organ. The chemical exchange-specific magnetic resonance data may be used to measure the proteoglycan content in the tissue or organ.
    Type: Application
    Filed: April 22, 2015
    Publication date: July 20, 2017
    Applicant: University of Pittsburgh-of The Commonwealth System of Higher Education
    Inventors: Wen LING, Tao JIN, Kyongtae Ty BAE
  • Publication number: 20130068628
    Abstract: Disclosed is a method for extracting gallium from fly ash, which comprises the following steps: crushing the fly ash and removing Fe by magnetic separation; then dissolving it by using hydrochloride acid (2) to obtain hydrochloric acid leachate; adsorbing gallium in the hydrochloric acid leachate with macro-porous cationic resin, followed by eluting to obtain the eluent (5) containing gallium; adding sodium hydroxide (6) solution into the eluent containing gallium to react and obtaining sodium metaaluminate solution containing gallium (8); introducing CO2 into the sodium metaaluminate solution containing gallium (8) for carbonation, followed by separating gallium from aluminum and obtaining aluminum-gallium double salt (15) with the gallium to alumina mass ratio being more than 1:340; adding the aluminum-gallium double salt (15) into sodium hydroxide (17) to react, followed by alkalinity-adjustment concentration to obtain alkali solution containing gallium and aluminum; electrolyzing (10) the alkali solution
    Type: Application
    Filed: April 27, 2011
    Publication date: March 21, 2013
    Applicant: CHINA SHENHUA ENERGY COMPANY LIMITED
    Inventors: Wen Ling, Yinshan Jiang, Cundi Wei, Nan Li, Dazhao Gu, Zhaohua Guo, Dianfan Yang, Junzhou Chi, Ping Zou
  • Publication number: 20110054299
    Abstract: An exemplary methodology, procedure, system, method and computer-accessible medium can be provided to determine one or more particular frequencies of cross-relaxation between at least one molecule and at least one particular compound, determine a chemical exchange based on magnetic resonance data using a further frequency which is different from the one or more particular frequencies, and derive particular information about the anatomical region of interest based on the chemical exchange.
    Type: Application
    Filed: January 7, 2009
    Publication date: March 3, 2011
    Inventors: Wen Ling, Ravinder R. Regatte, Gil Navon, Alexej Jerschow
  • Publication number: 20060276340
    Abstract: The present invention relates to a herbicidal composition, especially used as a rape field herbicide, prepared by mixing pyrimidinyl benzylamine herbicide (Pyribambenz-propyl or Pyribambenz-isopropyl) with at least one rape field herbicide selected from a group consisting of: acetyl-CoA carboxylase (ACCase) inhibitors including quizalofop-ethyl, fluazifop-p-butyl, haloxyfop, fenoxaprop, and sethoxydim; chloro-amido herbicides including acetochlor, alachlor, napropamide, ehaprochlor, and metolachlor; ethametsulfuron; and benazolin. The composition of the present invention is of synergistic effect, reduced dosage, broadened spectrum of weed control, delayed resistance and increased safety toward rape.
    Type: Application
    Filed: July 2, 2004
    Publication date: December 7, 2006
    Applicants: Zhejiang Chem-Tech Group Co., Ltd., Shanghai Institute of Organic Chemistry, Chinese
    Inventors: Jie Chen, Long Lu, Jun Yuan, Xiaoyan Xu, Wen Ling, Lishang Mao, Yonghua Wang
  • Patent number: 6800590
    Abstract: This invention relates to new 2-pyrimidinyloxy-N-aryl-benzylamine derivatives, their preparation processes and uses as chemical herbicides in agriculture. The compound has the following structure: wherein, D or E is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl or C1-C4 haloalkoxy; R1 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 carbamyl, C1-C4 alkoxycarbonyl, C1-C4 haloalkyl, cyano, nitro, carboxy or its alkali metal, alkali earth metal and organoammonium salts, C1-C4 alkylamido, C1-C4 haloalkylamido, heterocyclic amido, benzamido or substituted benzamido, benzo or substituted benzo compounds; R3 is hydrogen, C1-C4 alkanoyl, C1-C4 haloalkanoyl, benzoyl or C1-C4 alkoxyacetyl; X is CH or N; n=1-3.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: October 5, 2004
    Assignees: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Zheijiang Chemical Industry Research Institute
    Inventors: Long Lü, Jie Chen, Jun Wu, Wen Ling, Lisheng Mao, Mingzhi Li, Xian Cai, Weili Peng, Yong Wu, Shenggan Wu, Hongjun Wang, Guochao Wang, Hu Cui, Shidong Han, Weilian Qiu, Yonghua Wang
  • Publication number: 20030220198
    Abstract: This invention relates to new 2-pyrimidinyloxy-N-aryl-benzylamine derivatives, their preparation processes and uses as chemical herbicides in agriculture.
    Type: Application
    Filed: April 9, 2003
    Publication date: November 27, 2003
    Inventors: Long L, Jie Chen, Jun Wu, Wen Ling, Lisheng Mao, Mingzhi Li, Xian Cai, Weili Peng, Yong Wu, Shenggan Wu, Hongjun Wang, Guochao Wang, Hu Cui, Shidong Han, Weilian Qiu, Yonghua Wang