Abstract: To pick and place standard dies on a new base for obtaining an appropriate and wider distance between dies than the original distance of dies on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dies with a side by side structure or a stacking structure.

Abstract: The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

Abstract: The present invention describes a newly discovered full-length polynucleotide encoding an SH2/SH3 domain-containing adapter protein, called hSLAP-2, cloned, isolated and identified. Also described are the hSLAP-2 polypeptide sequence, expression vectors, host cells, agonists, antagonists, anti-sense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the hSLAP-2 protein and use of the hSLAP-2 polynucleotide and polypeptide for therapeutics and diagnostics are described.

Abstract: The present invention discloses an image sensor module and forming method of wafer level package. The image sensor module comprises an isolating base, a wafer level package, a lens holder, and a F.P.C.. The wafer level package having a plurality of image sensor dies and a plurality of solder balls is attached to the isolating base. A plurality of lens are placed in the lens holder, and the lens holder is located on the image sensor dies. The lens holder is placed in the F.P.C., and the F.P.C. has a plurality of solder joints coupled to the solder balls for conveniently transmitting signal of the image sensor dies. Moreover, the image sensor dies may be packaged with passive components or other dies with a side by side structure or a stacking structure.

Abstract: The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

Abstract: To pick and place standard dies on a new base for obtaining an appropriate and wider distance between dies than the original distance of dies on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dies with a side by side structure or a stacking structure.

Abstract: A method and an apparatus for switching channel connection between multiple optical channels synchronously and automatically. The apparatus employs an optical switch to interface among a plurality of optical channels, and an optical power meter to monitor data transmission over the plurality of optical channels by measuring the optical power level of optical signals over the channel. When signal transmission is detected over a specific optical channel, the optical switch is locked to the specific optical channel allowing data signals over the specific optical channel to be transmitted to a specific device or another optical channel through the optical switch. When no optical signal is detected over the channel, said optical switch will be switched to another optical channel, such that signal monitoring and switching channels among a plurality of optical channels is able to be performed synchronously and automatically.

Abstract: The present invention discloses an image sensor module and forming method of wafer level package. The image sensor module comprises an isolating base, a wafer level package, a lens holder, and a F.P.C.. The wafer level package having a plurality of image sensor dies and a plurality of solder balls is attached to the isolating base. A plurality of lens are placed in the lens holder, and the lens holder is located on the image sensor dies. The lens holder is placed in the F.P.C., and the F.P.C. has a plurality of solder joints coupled to the solder balls for conveniently transmitting signal of the image sensor dies. Moreover, the image sensor dies may be packaged with passive components or other dies with a side by side structure or a stacking structure.

Abstract: To pick and place standard dies on a new base for obtaining an appropriate and wider distance between dies than the original distance of dies on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dies with a side by side structure or a stacking structure .

Abstract: To pick and place standard dies on a new base for obtaining an appropriate and wider distance between dies than the original distance of dies on a wafer. The package structure has a larger size of balls array than the size of the die by fan out type package. Moreover, the die may be packaged with passive components or other dies with a side by side structure or a stacking structure.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.

Abstract: The present invention relates to compounds which act as modulators of the chloride channel CLC-7, assays for the identification of such compounds and methods of preventing, diagnosing, and treating osteoporosis and related disease states using such compounds.

Abstract: The present invention describes a newly discovered ubiquitin conjugating enzyme homologue, called RATL1d6 herein, and its encoding polynucleotide, isolated and identified from activated T lymphocytes. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the activity and use of the newly-discovered polynucleotide and/or polypeptide of the present invention. Methods for treating, diagnosing, preventing and screening for disorders related to the expression of the RATL1d6 ubiquitin conjugating enzyme polypeptide are described.

Abstract: An optical fiber switching device includes a holding base, a threaded axle and two guide spindles installed in the holding base, a motor connected with the threaded axle to drive the threaded axle to rotate, and a positioning block meshed with the threaded axle and supported by the two guide spindles. When the motor is actuated, the positioning block is linearly moved along the threaded axle and kept in balance, thus a first collimating lens disposed on the positioning block is able to be precisely aligned with a second collimating lens which is disposed at a side of the holding base. Because the first collimating lens and the second collimating lens are precisely in alignment, any possible insertion loss of the optical fiber switching device is minimized.

Abstract: The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

Abstract: A method and an apparatus for switching channel connection between multiple optical channels synchronously and automatically. The apparatus employs an optical switch to interface among a plurality of optical channels, and an optical power meter to monitor data transmission over the plurality of optical channels by measuring the optical power level of optical signals over the channel. When signal transmission is detected over a specific optical channel, the optical switch is locked to the specific optical channel allowing data signals over the specific optical channel to be transmitted to a specific device or another optical channel through the optical switch. When no optical signal is detected over the channel, said optical switch will be switched to another optical channel, such that signal monitoring and switching channels among a plurality of optical channels is able to be performed synchronously and automatically.

Abstract: The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

Abstract: The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.

Abstract: An optical fiber switching device includes a holding base, a threaded axle and two guide spindles installed in the holding base, a motor connected with the threaded axle to drive the threaded axle to rotate, and a positioning block meshed with the threaded axle and supported by the two guide spindles. When the motor is actuated, the positioning block is linearly moved along the threaded axle and kept in balance, thus a first collimating lens disposed on the positioning block is able to be precisely aligned with a second collimating lens which is disposed at a side of the holding base. Because the first collimating lens and the second collimating lens are precisely in alignment, any possible insertion loss of the optical fiber switching device is minimized.