Abstract: Aspects of present disclosures involve systems, methods, and apparatus for a bone mounted robotic-assisted orthopedic surgery system for precise implant position, soft tissue balancing, and guidance of tools during a surgical procedure, particularly partial or total knee replacement procedure. The system features a bone-mounted robotic arm with an end-effector for precise positioning of a surgical tool, positioning of implants, and balancing of soft tissues. The reconfigurable robotic system requires minimal training by surgeons, is intuitive to use similar to conventional instrumented surgery, and has a small footprint. The system works with existing, conventional instruments, patient-specific instruments, sensor-assisted systems, and computer-assisted systems and does not require increased surgical time and safely provides the enhanced precision achievable by robotic-assisted systems and computer-assisted technologies.

Abstract: The present disclosure relates to a novel method for lateral flow immunoassay (LFIA) by utilizing plasmonic enhancement strategy. More specifically, the present disclosure provides a plasmonic enhanced lateral flow sensor (pLFS) concept by introducing a liposome-based amplification of the colorimetric signals on the lateral flow platform for ultrasensitive detection of pathogens.

Abstract: Aspects of present disclosures involve systems, methods, computer program products for creating a customized MIS spine guide using two-dimensional imaging. In particular, the present disclosure provides a method of creating customized implant or instrument trajectory guide using one or more two-dimensional (2D) images of the patient's vertebrae. The method for creating a customized MIS spine guide using two-dimensional imaging generally includes receiving a plurality of two-dimensional images of the patient's vertebrae from an imaging device, reformatting the two-dimensional images for surgical planning and creating a customized MIS spine guide from the 2D images, design a jig based at least on the placement of the mating shapes within the plurality of reformatted two-dimensional images by the computing device, and creating a customized spine guide using a milling machine or 3D printing device corresponding to the machine program.

Abstract: Provided in the present invention is an ultralight artificial medium multilayer cylindrical lens, comprising n concentric layers of different dielectric constants. The center cylindrical layer is expressed as layer 1 and is a solid cylinder. Layers 2 to n are in a sequentially outward nested arrangement surrounding the center cylindrical layer and respectively are n-1 concentric rings. The n concentric layers are assembled into a multilayer cylinder and are characterized in that the dielectric constants of the n concentric layers gradually decrease from layer 1 to layer n and vary specifically between 2.05 to 1.05. The n concentric layers are made of a base material of low dielectric constant added with a material of high dielectric constant and low specific gravity. The lens so manufactured has a total apparent density of 0.08-0.095 g/cm3.

Abstract: Provided is a compound represented by formula (I). Also provided are a pharmaceutical composition containing the compound of formula (I) and use of the compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor drugs. The compound or the pharmaceutical composition thereof can be used for preparing drugs for preventing and/or treating diseases having pathological features of IDO-mediated tryptophan metabolic pathways.

Abstract: A layered graph data structure can be stored using a vertex table and an edge table. The vertex table includes a vertex identifier column and a first graph identifier column. The edge table includes a second graph identifier column, a node identifier column, and an edge type column. Queries of the layered graph data structure include a target entity and a graph level, and iterative searching of the vertex table and the edge table is performed based on the graph level and data stored in edge type column.

Abstract: Described within are systems, methods and apparatus for a bone mounted robotic-assisted orthopedic surgery system for precise implant position, soft tissue balancing and guidance of tools during a surgical procedure, particularly partial or total knee replacement procedure. The system features a bone mounted robotic arm with end-effector for precise positioning of surgical tool, positioning of implants and balancing of soft tissues. The reconfigurable robotic system requires minimal training by surgeons, is intuitive to use similar to conventional instrumented surgery and has a small footprint. The system works with existing, conventional instruments, patient specific instruments, sensor-assisted systems and computer-assisted systems and does not require increased surgical time and safely provides the enhanced precision achievable by robotic-assisted systems and computer-assisted technologies.

Abstract: An anode active material for a lithium-ion battery with greatly reduced recharging time includes SiO particles, graphite particles, and a carbon coating layer. The graphite particles and SiO particles are processed to form spherical SiO/graphite composite particles. A layer of carbon coating is applied to the surface of the SiO/graphite composite particle and the resulting anode active material resembles a pomegranate structure.

Abstract: A compound is represented by formula (I). A pharmaceutical composition contains the compound of formula (I). The compound is used in the preparation of an indoleamine-2,3-dioxygenase (IDO) inhibitor drug. The compound exhibits inhibition effect on IDO protease and metabolizes stably in the body. The compound or pharmaceutical composition thereof can be used for preparing an IDO inhibitor drug, and can also be used for preparing a drug for preventing and/or treating diseases having IDO-mediated tryptophan metabolic pathway pathological features.

Abstract: A metal-clad laminate is provided. The metal-clad laminate includes: a dielectric layer, which has a first reinforcing material and a dielectric material formed on the surface of the first reinforcing material, wherein the dielectric material includes 60 wt % to 80 wt % of a first fluoropolymer and 20 wt % to 40 wt % of a first filler; an adhesive layer, which is disposed on at least one side of the dielectric layer and includes an adhesive material, wherein the adhesive material has 60 wt % to 70 wt % of a second fluoropolymer and 30 wt % to 40 wt % of a second filler; and a metal foil, which is disposed on the other side of the adhesive layer that is opposite to the dielectric layer, wherein the melting point of the second fluoropolymer is lower than the melting point of the first fluoropolymer.

Abstract: Aspects of present disclosures involve systems, methods, computer program products for creating a customized MIS spine guide using two-dimensional imaging. In particular, the present disclosure provides a method of creating customized implant or instrument trajectory guide using one or more two-dimensional (2D) images of the patient's vertebrae. The method for creating a customized MIS spine guide using two-dimensional imaging generally includes receiving a plurality of two-dimensional images of the patient's vertebrae from an imaging device, reformatting the two-dimensional images for surgical planning and creating a customized MIS spine guide from the 2D images, design a jig based at least on the placement of the mating shapes within the plurality of reformatted two-dimensional images by the computing device, and creating a customized spine guide using a milling machine or 3D printing device corresponding to the machine program.

Abstract: Devices, systems, and methods are provided for magnetic focus enhanced lateral flow assays. The devices and systems are ultrasensitive and provide for the visual detection of the presence or absence of one or more target analytes—which may include pathogens, proteins, or even molecules smaller than the foregoing—even when such analytes are only present in very limited amounts. The devices and systems include an immunostrip with a magnet positioned adjacent thereto, and magnetic probes specific to a target analyte that bind to the target analyte with specificity if present within a fluid sample to be tested. Methods are also provided for detecting one or more target analytes using magnetic focus, such methods including a step of controlling movement of a target analyte complex on an immunostrip incorporating a magnetic field, where such control slows a flow of the target analyte complex through a capture area on the immunostrip.

Abstract: Provided in the present invention is an ultralight artificial medium multilayer cylindrical lens, comprising n concentric layers of different dielectric constants. The center cylindrical layer is expressed as layer 1 and is a solid cylinder. Layers 2 to n are in a sequentially outward nested arrangement surrounding the center cylindrical layer and respectively are n-1 concentric rings. The n concentric layers are assembled into a multilayer cylinder and are characterized in that the dielectric constants of the n concentric layers gradually decrease from layer 1 to layer n and vary specifically between 2.05 to 1.05. Then concentric layers are made of a base material of low dielectric constant added with a material of high dielectric constant and low specific gravity. The lens so manufactured has a total apparent density of 0.08-0.095 g/cm3.

Abstract: An anode active material for a lithium-ion battery with greatly reduced recharging time includes SiO particles, graphite particles, and a carbon coating layer. The graphite particles and SiO particles are processed to form spherical SiO/graphite composite particles. A layer of carbon coating is applied to the surface of the SiO/graphite composite particle and the resulting anode active material resembles a pomegranate structure.

Abstract: A layered graph data structure can be stored using a vertex table and an edge table. The vertex table includes a vertex identifier column and a first graph identifier column. The edge table includes a second graph identifier column, a node identifier column, and an edge type column. Queries of the layered graph data structure include a target entity and a graph level, and iterative searching of the vertex table and the edge table is performed based on the graph level and data stored in edge type column.

Abstract: The present disclosure relates to a wafer leveling device which comprises a carrier module, a fixture module and a dynamic module. A wafer, which is conveyed to and stays above a claw component of the carrier module by a robotic arm, is further carried by the lifted claw component for a continuous ascent until the wafer is contacted by a ring component of the fixture module; the clamp component of the fixture module releases the ring component; the claw component, the ring component and the wafer, all of which keep stabilized mutual positions, are lowered so that several protrudent structures on a base component of the carrier module contact the wafer; the claw component, the ring component and the wafer which completes a manufacturing process are lifted; the carrier module and the wafer are lowered with the clamp components stabilizing the ring component.

Abstract: A method of manufacturing a metal-clad laminate and uses of the same are provided. The method comprises the following steps: (a) impregnating a reinforcement material with a first fluoropolymer solution, and drying the impregnated reinforcement material under a first temperature to obtain a first prepreg; (b) impregnating the first prepreg with a second fluoropolymer solution, and drying the impregnated first prepreg under a second temperature to obtain a second prepreg; and (c) laminating the second prepreg and a metal-clad to obtain a metal-clad laminate, wherein the first fluoropolymer solution has a first fluoropolymer, the second fluoropolymer solution has a second fluoropolymer, and the first fluoropolymer and the second fluoropolymer are different.

Abstract: The present disclosure relates to a laser marking device and a method thereof. The laser marking device comprises a laser system, a wafer leveling system, a first imaging system and a mobile system: the wafer leveling system carries and levels a warped wafer to be processed; the mobile system underneath properly adjusts a position of the wafer; the first imaging system detects the wafer to recognize a product category and positioning status; the laser system underneath labels laser marks on the wafer; all wafers are marked in the cyclic process.

Abstract: The present disclosure relates to a wafer leveling device which comprises a carrier module, a fixture module and a dynamic module. A wafer, which is conveyed to and stays above a claw component of the carrier module by a robotic arm, is further carried by the lifted claw component for a continuous ascent until the wafer is contacted by a ring component of the fixture module; the clamp component of the fixture module releases the ring component; the claw component, the ring component and the wafer, all of which keep stabilized mutual positions, are lowered so that several protrudent structures on a base component of the carrier module contact the wafer; the claw component, the ring component and the wafer which completes a manufacturing process are lifted; the carrier module and the wafer are lowered with the clamp components stabilizing the ring component.

Abstract: The present invention discloses a method for recommending suppliers, which mainly comprises steps of: a server recording at least a supplier and at least a product related to the supplier; at least a client logging in the server and defining that the product belongs to a set; the client transmitting a social operating instruction related to the set; the server transmitting at least a questionnaire related to the set to the client; the client transmitting a questionnaire result related to the questionnaire to the server; the server executing the social operating instruction; the server compiling statistics of the client willing to buy or understand the product according to the questionnaire result for sorting the product; and the server enabling a shopping page or an advertisement page of the supplier to be related to the product according to the order of the product.