Abstract: Substituted alkylketo compounds of the formula can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.

Abstract: Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are methods of screening compounds useful for inhibiting vascular smooth muscle cell proliferation.

Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are methods of screening compounds useful for inhibiting vascular smooth muscle cell proliferation.

Abstract: A Spherical massager composed of two semispherical bodies. Each of the semispherical bodies has a soft facial layer on the surface. The soft facial layer is formed with multiple outward projecting contact sections. The mating faces of the two semispherical bodies are respectively disposed with a power supply section and an oscillation generating section. The power supply section has a recessed female connecting section formed on the connecting face of one of the semispherical bodies. The oscillation generating section including a male connecting section outward projecting from the mating face of the other semispherical body. The male connecting section is formed with a central hole for receiving a vibrating motor. An eccentric wheel is disposed at a front end of a rotary shaft of the vibrating motor to achieve a vibrating effect.

Abstract: A calorie counting racket has a skeleton (10) with a hollow grip (11) and a counter unit (20) secured inside the grip (11) with multiple press buttons and a display (25) protruding from a side surface of the grip (11). The counter unit (20) has a microprocessor (21), a frequency counter (22) to record numbers of swings of the racket, a force estimating unit (23) to detect acceleration of the skeleton (10), a set of press button to control the microprocessor (21), and a display (25) to show calorie data. So that the calorie counting racket determine the burned calories immediately and precisely in accordance with different users.

Abstract: A flip-chip bonding structure with stress-buffering property is proposed, which can help prevent cracking and warpage to the flip-chip construction due to thermal stress. The proposed flip-chip bonding structure used to bond a flip chip to a substrate, and is characterized in the provision of a first electrically-conductive stress-buffering layer over the chip-side bond pad and a second electrically-conductive stress-buffering layer over the substrate-side bond pad, so that under high-temperature conditions, the thermal stress from the flip chip can be buffered by the first electrically-conductive stress-buffering layer, while the thermal stress from the substrate can be buffered by the second electrically-conductive stress-buffering layer, thus preventing cracking and warpage to the flip-chip construction. As a result, the finished flip-chip package can be more assured in quality and reliability than the prior art.

Abstract: Substituted alkylketo compounds of the formula 1

Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.

Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Abstract: Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.

Abstract: A furniture device includes two or more plates and two or more panels and one or more boards each having a number of ribs for forming a number of openings. The plates each includes four corner blocks each having a number of helical fins for engaging with fasteners and for allowing the plates and the panels to be assembled together without being damaged. The plates each has a rear side portion having one or more grooves for engaging with the board and for allowing the boards to be secured between the plates without engaging with fasteners.

Abstract: A mouse model for transplant arteriosclerosis useful for identifying compounds which reduce or prevent such arteriosclerosis, consisting of a mouse engrafted with a histoincompatible artery which exhibits detectable arteriosclerosis within 30 days of transplantation. Also disclosed are therapeutic methods for inhibiting the development of transplant arteriosclerosis in mammalian recipients of allografted organs.

Abstract: A method is provided for preparing intermediates for 7-oxabicycloheptane carboxylic acid intermediates of the structures ##STR1## wherein R is alkyl, aryl, arylalkyl or cycloalkyl; R.sup.1 is alkyl, arylalkyl or cycloalkyl; R.sup.2 is aryl or arylalkyl; and of the structure ##STR2## where R and R.sup.1 are as defined above, which may be used in making the final anti-thrombotic--anti-vasospastic compounds.