Patents by Inventor Wen-Shen Chu

Wen-Shen Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7960162
    Abstract: Proteins isolated from Coprinus clastophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: June 14, 2011
    Assignee: Food Industry Research & Development Institute
    Inventors: Jen-Tao Chen, Mei-Li Chao, Wen-Shen Chu, Chiou-Yen Wen
  • Patent number: 7741094
    Abstract: A protein of amino acid sequence SEQ ID NO:6 isolated from Coprinus clastophyllus. The protein is stable at 30 to 37 degrees centigrade and has an optimal prolyl oligopeptidase activity at about 45 degree centigrade and at about pH 7. The present invention also relates to a medicament comprising such protein for treating celiac disease caused by proline abundant gluten.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: June 22, 2010
    Assignee: Food Industry Research & Development Institute
    Inventors: Jen-Tao Chen, Mei-Li Chao, Chiou-Yen Wen, Wen-Shen Chu
  • Publication number: 20100086558
    Abstract: Proteins isolated from Coprinus clastophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:9 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
    Type: Application
    Filed: October 19, 2009
    Publication date: April 8, 2010
    Applicant: Food Industry Research & Development Institute
    Inventors: Jen-Tao Chen, Mei-Li Chao, Wen-Shen Chu, Chiou-Yen Wen
  • Publication number: 20090269327
    Abstract: Proteins isolated from Coprinus clostophyllus having prolyl oligopeptidase activity, nucleic acids encoding the protein and methods for producing and using the protein, wherein SEQ ID NO:5, SEQ ID NO:6 and SEQ ID NO:10 must be contained therein to at least 60% similarity. The proteins and nucleic acids have improved heat stability and perform more favorably in vivo having optimum activity conditions around 40 degrees centigrade and around pH 7, and can therefore be used in medicaments for the treatment of celiac disease caused by proline abundant gluten or other applications.
    Type: Application
    Filed: April 24, 2008
    Publication date: October 29, 2009
    Inventors: Jen-Tao Chen, Mei-Li Chao, Chiou-Yen Wen, Wen-Shen Chu
  • Patent number: 7179628
    Abstract: A DNA molecule encoding transglutaminase, a transglutaminase, an expression vector containing the DNA molecule, and a cell containing the expression vector.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: February 20, 2007
    Assignee: Food Industry Research & Development Institute
    Inventors: Yi-Shin Lin, Mei-Li Chao, Chang-Hsiesh Liu, Min Tseng, Shie-Jea Lin, Wen-Shen Chu
  • Patent number: 6916639
    Abstract: An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: July 12, 2005
    Assignee: Food Industry Research and Development Institute
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Chang-Cheng Huang, Wen-Shen Chu
  • Publication number: 20050064571
    Abstract: A DNA molecule encoding translutaminase, a transglutaminase, an expression vector containing the DNA molecule, and a cell containing the expression vector. The DNA molecule is composed of a nucleotide sequence of SEQ ID NO: 1.
    Type: Application
    Filed: September 21, 2004
    Publication date: March 24, 2005
    Inventors: Yi-Shin Lin, Mei-Li Chao, Chang-Hsiesh Liu, Min Tseng, Shie-Jea Lin, Wen-Shen Chu
  • Patent number: 6660510
    Abstract: The invention provides a DNA molecule encoding transglutaminase of Streptoverticillium ladakanum, the encoded transglutaminase and the use of the transglutaminase in industrial process.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: December 9, 2003
    Assignee: Food Industry Research and Development
    Inventors: Yi-Shin Lin, Chang-Hsiesh Liu, Wen-Shen Chu
  • Publication number: 20030113407
    Abstract: The invention provides a DNA molecule encoding transglutaminase of Streptoverticillium ladakanum, the encoded transglutaminase and the use of the transglutaminase in industrial process.
    Type: Application
    Filed: December 17, 2001
    Publication date: June 19, 2003
    Applicant: FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE
    Inventors: Yi-Shin Lin, Chang-Hsiesh Liu, Wen-Shen Chu
  • Publication number: 20030008378
    Abstract: An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
    Type: Application
    Filed: July 22, 2002
    Publication date: January 9, 2003
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Chang-Cheng Huang, Wen-Shen Chu
  • Patent number: 6455301
    Abstract: An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: September 24, 2002
    Assignee: Food Industry Research and Develpment Institute
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Chang-Cheng Huang, Wen-Shen Chu
  • Publication number: 20020132313
    Abstract: An isolated strain of the Moniliella species that converts glucose to erythritol with a conversion rate of at least about 45% is disclosed, as is a method of producing erythritol from such a strain.
    Type: Application
    Filed: January 12, 2001
    Publication date: September 19, 2002
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Chang-Cheng Huang, Wen-Shen Chu
  • Patent number: 6448053
    Abstract: A method of producing erythritol. The method includes growing in a culture an isolated yeast strain that possesses certain unique characteristics and is capable of converting glucose to erythritol in a glucose-containing medium, and purifying erythritol from the culture.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: September 10, 2002
    Assignee: Food Industry Research and Development Institute
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Wen-Haw Hsu, Guey-Yuh Liou, Wen-Shen Chu
  • Publication number: 20020034795
    Abstract: A yeast strain capable of converting glucose to erythritol, said strain having the following identifying characteristics: an absence of motile spores; septate mycelia; asexual reproduction; an absence of reniform cells; conidia optionally formed on short denticles but not on elongate stalks; an absence of ballistoconidia; non-monopolar budding on a broad base; acropetal chains of blastoconidia; dark brown, thick-walled chlamydospores; an ability to assimilate sucrose, glycerol and maltose; an inability to assimilate lactose; an inability to ferment galactose; an ability to grow in a vitamin-free medium; and an ability to grow at 25° C. to 36° C.
    Type: Application
    Filed: September 25, 2001
    Publication date: March 21, 2002
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Wen-Haw Hsu, Guey-Yuh Liou, Wen-Shen Chu
  • Patent number: 6300107
    Abstract: A yeast strain capable of converting glucose to erythritol, said strain having the following identifying characteristics: an absence of motile spores; septate mycelia; asexual reproduction; an absence of reniform cells; conidia optionally formed on short denticles but not on elongate stalks; an absence of ballistoconidia; non-monopolar budding on a broad base; acropetal chains of blastoconidia; dark brown, thick-walled chlamydospores; an ability to assimilate sucrose, glycerol and maltose; an inability to assimilate lactose; an inability to ferment galactose; an ability to grow in a vitamin-free medium; and an ability to grow at 25° C. to 36° C.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: October 9, 2001
    Assignee: Food Industry Research & Development Institute
    Inventors: Shie-Jea Lin, Chiou-Yen Wen, Wen-Haw Hsu, Guey-Yuh Liou, Wen-Shen Chu
  • Patent number: 6235517
    Abstract: This invention relates to the isolation of thermophilic phytase-producing microorganisms, method for producing phytase using such microorganisms, phytase obtained therefrom, and usage of the phytase to hydrolyze phytic acid or phytate. In particular, this invention relates to phytase-producing microorganisms, which belong to Streptomyces sp., Pseudonocardia sp. or Microbispora sp., and which produce phytase available for recovery in an efficient and practical manner.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: May 22, 2001
    Assignee: Food Industry Research & Development Institute
    Inventors: Jaw-Shiow Chu, Su-Fang Chung, Min Tseng, Chiou-Yen Wen, Wen-Shen Chu
  • Patent number: 6180390
    Abstract: This invention relates to the isolation of thermophilic phytase-producing microorganisms, method for producing phytase using such microorganisms, phytase obtained therefrom, and usage of the phytase to hydrolyze phytic acid or phytate. In particular, this invention relates to phytase-producing microorganisms, which belong to Streptomyces sp., Pseudonocardia sp. or Microbispora sp., and which produce phytase available for recovery in an efficient and practical manner.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: January 30, 2001
    Assignee: Food Industry Research & Development Institute
    Inventors: Jaw-Shiow Chu, Su-Fang Chung, Min Tseng, Chiou-Yen Wen, Wen-Shen Chu
  • Patent number: 6033897
    Abstract: This invention relates to the isolation of thermophilic phytase-producing microorganisms, method for producing phytase using such microorganisms, phytase obtained therefrom, and usage of the phytase to hydrolyze phytic acid or phytate. In particular, this invention relates to phytase-producing microorganisms, which belong to Streptomyces sp., Pseudonocardia sp. or Microbispora sp., and which produce phytase available for recovery in an efficient and practical manner.
    Type: Grant
    Filed: September 13, 1999
    Date of Patent: March 7, 2000
    Assignee: Food Industry Research & Development Institute
    Inventors: Jaw-Shiow Chu, Su-Fang Chung, Min Tseng, Chiou-Yen Wen, Wen-Shen Chu
  • Patent number: 5877013
    Abstract: This invention relates to a D-amino acid oxidase of the genus Rhodosporidium and a gene encoding it.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: March 2, 1999
    Assignee: Food Industry Research and Development Institute
    Inventors: Gwo-Jen Liao, Yi-Jang Lee, Yun-Huey Lee, Li-Lin Chen, Wen-Shen Chu
  • Patent number: 5766871
    Abstract: A method of screening for a given enzyme in colony-forming cells using a substrate of the enzyme that has low solubility. Use of such a method leads to the discovery of glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase of Pseudomonas nitroreducens. Also disclosed is a method of obtaining GL-7-ACA acylase from Pseudomonas cells.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: June 16, 1998
    Assignee: Food Industry Research and Development Institute
    Inventors: Wen-Shen Chu, Yun-Huey Lee, Ming-Chu Chen, Li-Lin Chen, Chiou-Yen Wen