Abstract: The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene. The screening method uses the above cell, a suprachiasmatic nucleus section or peripheral tissue of the above transgenic animal or the above transgenic animal.

Abstract: The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscillatory expression of a biological clock gene.

Abstract: A novel type of insect control agent and methods for controlling insect pests are described. The agent consists of a vector, such as a baculovirus of the polyhedral inclusion body type, containing in an antisense orientation cDNA sequence which has been derived from the complete sense sequence of a gene which is essential for the growth and development of the host from which the sequence is derived. In order for the insect control agent to exert its effect the insect pests which are to be controlled must be susceptible to the vector. Specifically described are the sequences from Choristoneura fumiferana and the human c-myc gene as well the methods of production and use of these agents.