Patents by Inventor Wenbo ZHENG
Wenbo ZHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12216040Abstract: Provided are a sample analyzer and a sample analysis method. The sample analyzer includes: a sampling apparatus configured to collect a blood sample; a sample preparation apparatus configured to mix the blood sample with a hemolytic agent and a dye to prepare a test sample liquid; an optical detection apparatus configured to detect side-scattered light signals and fluorescence signals generated by particles in the test sample liquid; and a processor configured to: generate a scatter diagram based on at least the side-scattered light signals and the fluorescence signals, and obtain a predetermined feature region, wherein an intensity of side-scattered light corresponding to a central position of the predetermined feature region is greater than an intensity of side-scattered light corresponding to a central position of a region containing neutrophil granulocyte population; and obtain a blast cell parameter based on the predetermined feature region.Type: GrantFiled: April 7, 2022Date of Patent: February 4, 2025Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Wenbo Zheng, Bo Ye, Mingjin Guo, Chuanjian Wu, Huan Qi
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Patent number: 12158409Abstract: Disclosed are a blood analysis system, a blood analyzer, a blood analysis method and a storage medium. The blood analysis method includes: acquiring at least two types of optical signals of a test sample derived from a blood sample, wherein red blood cells in the test sample are lysed, blood cells in the test sample are stained by a fluorescence dye, and the at least two types of optical signals include scattered light signals and/or fluorescent signals; generating a scattergram based on the at least two types of optical signals; identifying a preset region in the scattergram based on the at least two types of optical signals; and acquiring detection data of a platelet subpopulation based on the preset region.Type: GrantFiled: October 23, 2020Date of Patent: December 3, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Bo Ye, Huan Qi, Wenbo Zheng, Yi Ye
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Patent number: 12135287Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: GrantFiled: October 9, 2023Date of Patent: November 5, 2024Inventors: Huan Qi, Wenbo Zheng, Bo Ye, Zhaoyang Li, Yi Ye
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Publication number: 20240353310Abstract: The present invention relates to a blood cell analyzer, a method, and a use of an infection marker parameter. The blood cell analyzer comprises a sample suction device used for aspirating a blood sample to be tested of a subject, a sample preparation device used for preparing a test sample containing a part of a blood sample to be tested, a hemolytic agent, and a staining agent for identifying nucleated red blood cells, an optical detection device used for detecting an test sample to obtain optical information, and a processor. The processor obtains from the optical information at least one leukocyte characteristic parameter of at least one target particle population in a test sample, obtains an infection marker parameter for evaluating an infection status of a subject on the basis of the at least one leukocyte characteristic parameter, and outputs the infection marker parameter.Type: ApplicationFiled: June 29, 2024Publication date: October 24, 2024Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Jin LI, Shiyao PAN, Xiaomei ZHANG, Chuanjian WU, Wenbo ZHENG, Bo YE
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Patent number: 12099049Abstract: Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect.Type: GrantFiled: March 3, 2022Date of Patent: September 24, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Wenbo Zheng, Bo Ye, Wentao Wei
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Patent number: 12046333Abstract: A blood cell analysis method and a blood cell analyzer are provided. In the method and analyzer, characteristic information of white blood cell fragments is obtained based on side scattered light information and fluorescence information, characteristic information of platelets is obtained based on forward scattered light information and fluorescence information and then a count value for the platelets is acquired based on the characteristic information of the platelets and the characteristic information of the white blood cell fragments. The present invention can avoid the influence of the white blood cell fragments on the platelet counting, thereby ensuring the accuracy of the platelet counting without increasing costs.Type: GrantFiled: November 14, 2022Date of Patent: July 23, 2024Assignee: SHENZHEN MINDRAY BIO- MEDICAL ELECTRONICS CO., LTD.Inventors: Bo Ye, Changsong Hu, Huan Qi, Wenbo Zheng
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Publication number: 20240230621Abstract: Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system and a storage medium.Type: ApplicationFiled: December 11, 2023Publication date: July 11, 2024Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Huan QI, Bo YE, Wenbo ZHENG, Changsong HU, Qi YU
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Publication number: 20240159640Abstract: An ESR detection device and an ESR detection method are provided, the ESR detection device including a sample collecting and dispensing module, an ESR detection module and a data processing module. The sample collecting and dispensing module is configured for dispensing at least part of a blood sample to the ESR detection module. The ESR detection module is configured for obtaining disaggregation optical data during disaggregation of erythrocytes and/or aggregation optical data during reaggregation of erythrocytes. The data processing module is configured for obtaining an ESR detection result of the blood sample based on the aggregation optical data, determining, based on the disaggregation optical data and/or the aggregation optical data, whether or not there is a sample abnormality that leads to an abnormality in the ESR detection result, and outputting an alarm prompt when it is determined that the sample abnormality is present, thereby reducing clinical risk.Type: ApplicationFiled: November 15, 2023Publication date: May 16, 2024Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Wenbo ZHENG, Jinxiu SI, Bo YE, Wenpeng XUN
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Publication number: 20240133864Abstract: Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system and a storage medium.Type: ApplicationFiled: December 11, 2023Publication date: April 25, 2024Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Huan QI, Bo YE, Wenbo ZHENG, Changsong HU, Qi YU
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Publication number: 20240044793Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: ApplicationFiled: October 9, 2023Publication date: February 8, 2024Inventors: Huan QI, Wenbo ZHENG, Bo YE, Zhaoyang LI, Yi YE
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Patent number: 11874212Abstract: A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.Type: GrantFiled: October 23, 2020Date of Patent: January 16, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Bo Ye, Wenbo Zheng, Huan Qi, Zhaoyang Li
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Patent number: 11841358Abstract: Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system (100) and a storage medium.Type: GrantFiled: October 20, 2020Date of Patent: December 12, 2023Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Huan Qi, Bo Ye, Wenbo Zheng, Changsong Hu, Qi Yu
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Publication number: 20230333093Abstract: A sample analyzer includes a sample preparation device, an impedance testing device, an optical testing device, and a controller. The controller is configured to control the impedance testing device to test a first test sample to obtain a first platelet counting result for a test blood sample based on electronic information of the first test sample; control the optical testing device to test a second test sample to obtain a second platelet counting result for the test blood sample based only on optical information of the second test sample or based on both the electronic information of the first test sample and the optical information of the second test sample; determine whether the first platelet counting result is unreliable due to abnormality of the test blood sample; and output the first and/or the second platelet counting result according to the result of the determination.Type: ApplicationFiled: April 14, 2023Publication date: October 19, 2023Inventors: Wenbo ZHENG, Bo YE, Donglan YAO, Huan QI, Yi YE
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Patent number: 11781983Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: GrantFiled: October 23, 2020Date of Patent: October 10, 2023Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Huan Qi, Wenbo Zheng, Bo Ye, Zhaoyang Li, Yi Ye
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Publication number: 20230071301Abstract: A blood cell analysis method and a blood cell analyzer are provided. In the method and analyzer, characteristic information of white blood cell fragments is obtained based on side scattered light information and fluorescence information, characteristic information of platelets is obtained based on forward scattered light information and fluorescence information and then a count value for the platelets is acquired based on the characteristic information of the platelets and the characteristic information of the white blood cell fragments. The present invention can avoid the influence of the white blood cell fragments on the platelet counting, thereby ensuring the accuracy of the platelet counting without increasing costs.Type: ApplicationFiled: November 14, 2022Publication date: March 9, 2023Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Bo YE, Changsong HU, Huan QI, Wenbo ZHENG
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Patent number: 11501852Abstract: A blood cell analysis method and a blood cell analyzer are provided. In the method and analyzer, characteristic information of white blood cell fragments is obtained based on side scattered light information and fluorescence information, characteristic information of platelets is obtained based on forward scattered light information and fluorescence information and then a count value for the platelets is acquired based on the characteristic information of the platelets and the characteristic information of the white blood cell fragments. The present invention can avoid the influence of the white blood cell fragments on the platelet counting, thereby ensuring the accuracy of the platelet counting without increasing costs.Type: GrantFiled: August 15, 2019Date of Patent: November 15, 2022Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Bo Ye, Changsong Hu, Huan Qi, Wenbo Zheng
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Publication number: 20220334046Abstract: Provided are a sample analyzer and a sample analysis method. The sample analyzer includes: a sampling apparatus configured to collect a blood sample; a sample preparation apparatus configured to mix the blood sample with a hemolytic agent and a dye to prepare a test sample liquid; an optical detection apparatus configured to detect side-scattered light signals and fluorescence signals generated by particles in the test sample liquid; and a processor configured to: generate a scatter diagram based on at least the side-scattered light signals and the fluorescence signals, and obtain a predetermined feature region, wherein an intensity of side-scattered light corresponding to a central position of the predetermined feature region is greater than an intensity of side-scattered light corresponding to a central position of a region containing neutrophil granulocyte population; and obtain a blast cell parameter based on the predetermined feature region.Type: ApplicationFiled: April 7, 2022Publication date: October 20, 2022Inventors: Wenbo ZHENG, Bo YE, Mingjin GUO, Chuanjian WU, Huan QI
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Publication number: 20220334099Abstract: Blood analysis apparatus, method, and storage medium are provided, including: obtaining optical signals of a first test sample; determining a first test result of a blood sample from the optical signals of the first test sample; determining whether any one or a combination of reticulocytes, immature platelets and large-volume platelets in the blood sample is abnormal from the optical signals of the first test sample; outputting the first test result if it is determined that reticulocytes, immature platelets and large-volume platelets in the blood sample are normal; if it is determined that any one or a combination of reticulocytes, immature platelets and large-volume platelets in the blood sample is abnormal, preparing a second test sample and obtaining optical signals of the second test sample; and obtaining a second test result of the blood sample from the optical signals of the second test sample and outputting the first test result.Type: ApplicationFiled: April 13, 2022Publication date: October 20, 2022Inventors: Wenbo ZHENG, Bo YE, Donglan YAO, Yi YE, Huan QI
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Patent number: 11402370Abstract: An alarming method for a platelet aggregation sample can include providing a blood sample, preparing a first test sample from the blood sample under a first reaction condition, acquiring a test signal of the first test sample, and obtaining first platelet test data. The method can also include preparing a second test sample from the blood sample under a second reaction condition, acquiring a test signal of the second test sample, and obtaining second platelet test data. The method can further include obtaining an evaluation result based on the first platelet test data and the second platelet test data, determining whether the evaluation result meets a predetermined condition, and alarming that the blood sample may be the platelet aggregation sample if the evaluation result meets the predetermined condition. The second reaction condition may include a reaction condition for reducing the platelet aggregation degree of the blood sample.Type: GrantFiled: March 4, 2020Date of Patent: August 2, 2022Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Bo Ye, Wenbo Zheng, Huan Qi, Xuerong Li
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Publication number: 20220187278Abstract: Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect.Type: ApplicationFiled: March 3, 2022Publication date: June 16, 2022Inventors: Wenbo ZHENG, Bo YE, Wentao WEI