Patents by Inventor Wenbo ZHENG

Wenbo ZHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220187278
    Abstract: Provided are a method and device for recognizing hook effect in immune turbidimetry, and a computer readable medium. This method generates a reaction curve using light signals measured in a predetermined time period by immune reaction of analyte in a sample, and uses distribution information of the reaction curve in the predetermined time period to determine whether the sample has hook effect. This method only uses measurement information of a small predetermined time period in entire reaction time to determine whether a sample has hook effect, and terminates the test in time, thus accelerating the speed of immune turbidimetry detection of samples with hook effect.
    Type: Application
    Filed: March 3, 2022
    Publication date: June 16, 2022
    Inventors: Wenbo ZHENG, Bo YE, Wentao WEI
  • Patent number: 11125687
    Abstract: A method for identifying fragmented red blood cells comprising: acquiring side scatter light signals and fluorescence signals of cell particles in a sample liquid; and distinguishing and identifying a fragmented red blood cell population from the cell particles according to the side scatter light signals and the fluorescence signals of the cell particles. The fragmented red blood cell population can be identified from the cell particles by processing and analyzing the side scatter light signals and fluorescence signals of the sample liquid. The present application further provides a device for identifying fragmented red blood cells, a blood cell analyzer and an analysis method. Fragmented red blood cells can be identified according to the fluorescence that characterizes a nucleic acid content in a cell particle and the side scatter light, thus reducing errors in identification and counting.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: September 21, 2021
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Wenbo Zheng, Bo Ye, Huan Qi, Shan Yu, Xiujuan Li, Zhaoyang Li
  • Publication number: 20210164885
    Abstract: Disclosed are a method for detecting a blood sample, a blood cell analyzer, and a storage medium. The method includes: acquiring at least two types of optical signal values of cells in a sample from a target detection channel, and generating a scattergram or a data array according to the at least two types of optical signal values of the cells; detecting cell distribution information of an aging characteristic region in the scattergram or data array; and outputting a detection result according to the cell distribution information.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 3, 2021
    Inventors: Bo YE, Wenbo ZHENG, Jin LI, Huan QI, Ruiteng TANG
  • Publication number: 20210041343
    Abstract: A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Inventors: Bo YE, Wenbo ZHENG, Huan QI, Zhaoyang LI
  • Publication number: 20210041344
    Abstract: Disclosed are a blood analysis system, a blood analyzer, a blood analysis method and a storage medium. The blood analysis method includes: acquiring at least two types of optical signals of a test sample derived from a blood sample, wherein red blood cells in the test sample are lysed, blood cells in the test sample are stained by a fluorescence dye, and the at least two types of optical signals include scattered light signals and/or fluorescent signals; generating a scattergram based on the at least two types of optical signals; identifying a preset region in the scattergram based on the at least two types of optical signals; and acquiring detection data of a platelet subpopulation based on the preset region.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Inventors: Bo YE, Huan QI, Wenbo ZHENG, Yi YE
  • Publication number: 20210041361
    Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 11, 2021
    Inventors: Huan QI, Wenbo ZHENG, Bo YE, Zhaoyang LI, Yi YE
  • Publication number: 20210033593
    Abstract: Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system (100) and a storage medium.
    Type: Application
    Filed: October 20, 2020
    Publication date: February 4, 2021
    Inventors: Huan QI, Bo YE, Wenbo ZHENG, Changsong HU, Qi YU
  • Publication number: 20210033592
    Abstract: A blood analyzer and a blood analysis method thereof are provided. The blood analyzer includes a test sample preparation apparatus, a flow chamber, a measurement apparatus and a data processor. The method adopts a white blood cell measurement channel to detect a test blood sample subjected to hemolysis and fluorescence staining and utilizes data in a blood ghost region to identify reticulocyte particles, thereby realizing differentiation of reticulocytes and large platelets and realizing finer classification and count of reticulocytes without separately designing an optical detection channel in the blood analyzer. A computer readable storage medium is also disclosed, in which a program is stored, and the program can be executed by the data processor to implement the above method.
    Type: Application
    Filed: October 20, 2020
    Publication date: February 4, 2021
    Inventors: Bo YE, Huan QI, Wenbo ZHENG, Yi YE
  • Publication number: 20200209218
    Abstract: An alarming method for a platelet aggregation sample can include providing a blood sample, preparing a first test sample from the blood sample under a first reaction condition, acquiring a test signal of the first test sample, and obtaining first platelet test data. The method can also include preparing a second test sample from the blood sample under a second reaction condition, acquiring a test signal of the second test sample, and obtaining second platelet test data. The method can further include obtaining an evaluation result based on the first platelet test data and the second platelet test data, determining whether the evaluation result meets a predetermined condition, and alarming that the blood sample may be the platelet aggregation sample if the evaluation result meets the predetermined condition. The second reaction condition may include a reaction condition for reducing the platelet aggregation degree of the blood sample.
    Type: Application
    Filed: March 4, 2020
    Publication date: July 2, 2020
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Bo YE, Wenbo ZHENG, Huan QI, Xuerong LI
  • Publication number: 20190371434
    Abstract: A blood cell analysis method and a blood cell analyzer are provided. In the method and analyzer, characteristic information of white blood cell fragments is obtained based on side scattered light information and fluorescence information, characteristic information of platelets is obtained based on forward scattered light information and fluorescence information and then a count value for the platelets is acquired based on the characteristic information of the platelets and the characteristic information of the white blood cell fragments. The present invention can avoid the influence of the white blood cell fragments on the platelet counting, thereby ensuring the accuracy of the platelet counting without increasing costs.
    Type: Application
    Filed: August 15, 2019
    Publication date: December 5, 2019
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Bo YE, Changsong HU, Huan QI, Wenbo ZHENG
  • Publication number: 20190360929
    Abstract: A method for identifying fragmented red blood cells comprising: acquiring side scatter light signals and fluorescence signals of cell particles in a sample liquid; and distinguishing and identifying a fragmented red blood cell population from the cell particles according to the side scatter light signals and the fluorescence signals of the cell particles. The fragmented red blood cell population can be identified from the cell particles by processing and analyzing the side scatter light signals and fluorescence signals of the sample liquid. The present application further provides a device for identifying fragmented red blood cells, a blood cell analyzer and an analysis method. Fragmented red blood cells can be identified according to the fluorescence that characterizes a nucleic acid content in a cell particle and the side scatter light, thus reducing errors in identification and counting.
    Type: Application
    Filed: August 12, 2019
    Publication date: November 28, 2019
    Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: Wenbo ZHENG, Bo YE, Huan QI, Shan YU, Xiujuan LI, Zhaoyang LI