Abstract: Disclosed herein are compounds that can be used to selectively detect nitric oxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting nitric oxide using the compounds.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: Provided herein are polysiloxane matrices and biocompatible films thereof for the detection of oxygen. In particular, oxygen-sensitive fluorophores embedded within polysiloxane matrices are utilized for detection of oxygen consumption rate in living cells.

Abstract: Conjugates comprise a drug or probe, a cell binding agent, and a quinone-containing linker. The quinone-containing linker may be reduced intracellularly to trigger release of the drug or probe. These conjugates may selectively deliver a drug or probe to a site of action of interest for local release of the active drug or probe.

Abstract: Provided herein are compounds, compositions, and methods for rapid isolation of nucleic acids from a sample.

Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.

Abstract: Provided herein multifunctional compounds that bind and modify nucleic acids, forming crosslinks between the nucleic acid strands. In particular embodiments, the multifunctional nucleic-acid binding/modifying compounds are selective for nucleic acids of non-viable cells and viruses (i.e., they are excluded from or degraded within viable cells and viruses), and therefore find use in methods for detecting or discriminating viable and non-viable cells/viruses and nucleic acids therefrom.

Abstract: Provided herein are compounds, compositions, systems, and methods for photoactivatable labeling, which can be actuated within biological systems. In particular, compounds disclosed herein include vinyl-extended-aryl azide moieties that undergo photoactivation to generate reactive intermediates, which can form covalent linkages with biomolecules. The photoactivation can be conducted by a variety of mechanisms including ultraviolet (UV) irradiation, visible light irradiation, or energy transfer (e.g., from a photocatalyst). The compounds also include functional moieties that provide useful functionalities, for example detection of biomolecules, such as fluorophores, capture elements (e.g., biotin), or reactive moieties (e.g., click handles) and bifunctional moieties comprising a bioactive compound and a detection/capture element.

Abstract: Disclosed herein are compounds that can be used to selectively detect superoxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting superoxide using the compounds.

Abstract: Disclosed herein are functionalized oxazine dye compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in nucleic acid amplification reactions. Also disclosed herein are labeled oligonucleotides and labeled nucleotide triphosphate compounds.

Abstract: An angle valve structure includes an angle valve body. The angle valve body is provided with a water inlet channel, a water outlet channel and an accommodation cavity. The accommodation cavity is rotationally provided with a valve core. One end of the valve core exposed outside the accommodation cavity is fixedly connected with a knob. The valve core is provided with a sealing block for sealing the water outlet channel when sealing. The valve core includes a main body part and an elastic arm whose one end is connected with the main body part. One side of the main body part is provided with a mounting slot for placing the sealing block, one side of the elastic arm is provided with an extrusion portion, and the other side of the elastic arm is provided with a contact portion against the sealing block after assembly.

Abstract: Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

Abstract: An angle valve structure includes an angle valve body. The angle valve body is provided with a water inlet channel, a water outlet channel and an accommodation cavity. The accommodation cavity is rotationally provided with a valve core. One end of the valve core exposed outside the accommodation cavity is fixedly connected with a knob. The valve core is provided with a sealing block for sealing the water outlet channel when sealing. The valve core includes a main body part and an elastic arm whose one end is connected with the main body part. One side of the main body part is provided with a mounting slot for placing the sealing block, one side of the elastic arm is provided with an extrusion portion, and the other side of the elastic arm is provided with a contact portion against the sealing block after assembly.

Abstract: Compounds that may inhibit Oplophorus-derived luciferases are disclosed as well as compositions and kits comprising the compounds and methods of using the compounds.

Abstract: Provided herein are methods, reagents, and kits for the isolation of sperm cells from other cell types and the purification of sperm-associated DNA from a complex sample. In particular, methods, reagents, and kits are provided for the separation of intact sperm cells from epithelial cells via binding of sperm cells to a cation exchange resin, and the extraction of sperm-associated DNA therefrom.

Abstract: A mounting bracket includes a bracket body, a locking assembly and support foot. The bracket body is configured for component installation. The locking assembly is arranged on the bracket body, and the support foot is arranged on the bracket body. The support foot is slide along the up and down direction of the bracket body, and the locking assembly is configured to lock the support foot at a preset position. Through the above structure, the support foot is installed on the ground and used to support the bracket body, and the locking assembly locks the support foot at a preset position to correspondingly adjust the height of the bracket body from the ground, so as to adjust the suspension height of the components installed on the bracket body.

Abstract: Disclosed herein are compounds that can be used to selectively detect nitric oxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting nitric oxide using the compounds.

Abstract: Disclosed herein are compounds that can be used to selectively detect superoxide in samples. Also disclosed herein are compositions comprising the compounds and methods of detecting superoxide using the compounds.

Abstract: The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.

Abstract: An adjustable height square outer cover with a built-in cylinder includes a water tank shell and a square outer cover, the water tank shell is provided with an installation accommodation cavity for containing the square outer cover, the water tank shell is also provided with support rack teeth, a locking release device is arranged in the square outer cover, and the locking release device is provided with locking release rack teeth matched with the support rack teeth. A first mounting cavity is arranged in the square outer cover, a support which can be adjusted horizontally is movably arranged in the first mounting cavity, a cylinder which can be adjusted longitudinally is movably arranged on the support, a pressing button is arranged on the cylinder, and the square outer cover is also clamped with a decorative cover for covering the first mounting cavity.