Patents by Inventor Wenling Zhang
Wenling Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11919835Abstract: The present invention relates to a method for preparing pregabalin by a biological enzyme method. In particular, the method comprises producing pregabalin B and an R-configuration compound C by using a compound A as a raw material under the action of a biological enzyme; performing configuration inversion of the separated and recovered R-configuration compound C under the action of an isomerase to produce an S-configuration compound D; and producing pregabalin B from the compound D under the action of a biological enzyme.Type: GrantFiled: December 4, 2020Date of Patent: March 5, 2024Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTDInventors: Changming Yang, Pan Guo, Yifeng Wang, Wenling Zhang, Peng Wang
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Publication number: 20230051211Abstract: A vehicle lamp assembly, a vehicle lamp and a corresponding motor vehicle. The vehicle lamp assembly including a support, for supporting a light emitting body. The vehicle lamp assembly further includes a housing provided to overlap with at least a part of the support and a first gap formed between the overlapping portions of the housing and the support. The vehicle lamp assembly additionally includes a first light blocking layer, with the first light blocking layer being provided between the overlapping portions of the housing and the support, and at least partially filling the first gap, so as to prevent light from the light emitting body from emitting outwards through the first gap.Type: ApplicationFiled: July 22, 2020Publication date: February 16, 2023Applicant: VALEO VISIONInventors: Qiuyang TAO, Wenling ZHANG, Dong YANG
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Patent number: 11548431Abstract: A problem to be solved by an embodiment of the present invention is how to reduce the load-bearing requirement for a supporting bracket. According to an embodiment of the present invention, a supporting bracket of a vehicle headlight is disclosed, wherein the supporting bracket includes a first supporting part for supporting a low beam unit; a second supporting part for supporting a high beam unit; and a first rotary part for causing the first supporting part and the second supporting part to rotate simultaneously in a horizontal direction about the rotation axis of the first rotary part.Type: GrantFiled: December 24, 2019Date of Patent: January 10, 2023Assignee: VALEO VISIONInventors: Chen Chen, Wenling Zhang, Bin Han
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Patent number: 11420932Abstract: A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method.Type: GrantFiled: December 4, 2020Date of Patent: August 23, 2022Assignee: ZHEIJIANG HUAHAI PHARMACEUTICAL CO., LTD.Inventors: Changming Yang, Pan Guo, Yifeng Wang, Wenling Zhang, Peng Wang
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Publication number: 20220097598Abstract: A problem to be solved by an embodiment of the present invention is how to reduce the load-bearing requirement for a supporting bracket. According to an embodiment of the present invention, a supporting bracket of a vehicle headlight is disclosed, wherein the supporting bracket includes a first supporting part for supporting a low beam unit; a second supporting part for supporting a high beam unit; and a first rotary part for causing the first supporting part and the second supporting part to rotate simultaneously in a horizontal direction about the rotation axis of the first rotary part.Type: ApplicationFiled: December 24, 2019Publication date: March 31, 2022Applicant: VALEO VISIONInventors: Chen CHEN, Wenling ZHANG, Bin HAN
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Patent number: 11008357Abstract: Disclosed is a method for preparing a canagliflozin form. The method comprises the following steps: adding canagliflozin into an organic solvent and dissolving same, then distilling into a certain amount of an oil; then, adding an anti-solvent to the oil, stirring same with a precipitated solid, cooling, filtering, and drying to obtain the canagliflozin amorphous form. The preparation method has the characteristics of a low solvent ratio, a high yield, a simple operation, easy recovery, less three wastes and good producibility, with the resulting product having a stable quality, good fluidity, and being suitable for the preparation of formulations, etc., and the preparation process is easy to apply to large commercial production, and has a high value in terms of promotion and application.Type: GrantFiled: February 6, 2018Date of Patent: May 18, 2021Inventors: Gang Qian, Yanbao Zhou, Linxiang Zhang, Wenling Zhang
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Publication number: 20210114972Abstract: The present invention relates to a method for preparing pregabalin by a biological enzyme method.Type: ApplicationFiled: December 4, 2020Publication date: April 22, 2021Inventors: Changming YANG, Pan Guo, Yifeng Wang, Wenling Zhang, Peng Wang
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Publication number: 20210114970Abstract: A method for preparing pregabalin chiral intermediate (R)-3-(carbamoylmethyl)-5-methylhexanoic acid by a biological enzyme method.Type: ApplicationFiled: December 4, 2020Publication date: April 22, 2021Inventors: Changming YANG, Pan GUO, Yifeng WANG, Wenling ZHANG, Peng WANG
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Publication number: 20200165284Abstract: Disclosed is a method for preparing a canagliflozin form. The method comprises the following steps: adding canagliflozin into an organic solvent and dissolving same, then distilling into a certain amount of an oil; then, adding an anti-solvent to the oil, stirring same with a precipitated solid, cooling, filtering, and drying to obtain the canagliflozin amorphous form. The preparation method has the characteristics of a low solvent ratio, a high yield, a simple operation, easy recovery, less three wastes and good producibility, with the resulting product having a stable quality, good fluidity, and being suitable for the preparation of formulations, etc., and the preparation process is easy to apply to large commercial production, and has a high value in terms of promotion and application.Type: ApplicationFiled: February 6, 2018Publication date: May 28, 2020Inventors: Gang QIAN, Yanbao ZHOU, Linxiang ZHANG, Wenling ZHANG
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Patent number: 10577309Abstract: Provided is a method for preparing a pregabalin intermediate 3-isobutylglutaric acid monoamide. The method comprises: 1) adding 3-isobutylglutaric acid and urea into a first organic solvent; 2) keeping warm and refluxing when heated to 100-140° C.; 3) adding water when cooled to 70-90° C.; 4) adding an ion membrane alkaline when cooled to 40-60° C., adjusting the pH to 11.0-14.0, then keeping warm at 40-60° C.; 5) when finished keeping warm, removing an organic layer; 6) adding an acid into the water layer to adjust the pH to 1.0-3.0; 7) extracting the solution acquired in step 6) by using a second organic solvent of a total volume of V, vacuum distilling 0.5-0.6 V of the organic solvent from an organic layer acquired by extraction; and 8) cooling to 0-15° C. and crystallizing to acquire 3-isobutylglutaric acid monoamide.Type: GrantFiled: June 21, 2017Date of Patent: March 3, 2020Assignees: ZHEJIANG HUAHAI PHARMACEUTICALS CO., LTD, ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO., LTDInventors: Pan Guo, Musong Liu, Zengle Zhou, Wenling Zhang, Peng Wang
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Patent number: 10538507Abstract: Provided is a purifying method for dabigatran etexilate free base, comprising subjecting a dabigatran etexilate free base crude product to water slurrying to obtain a crude product B; then conducting recrystallization on the crude product B with acetone and water to obtain a crude product C; and subsequently, purifying the crude product C with a mixed solvent of tetrahydrofuran and ethyl acetate, filtering and drying to obtain a dabigatran etexilate free base finished product. The purifying method of the present invention can effectively remove various impurities and is suitable for workshop production. Salts and water-soluble organic impurities are removed by purified water slurrying, impurities with a high polarity are removed by purifying with an acetone-water solution, and impurities with a low polarity are removed by purifying with a mixed solvent of tetrahydrofuran and ethyl acetate.Type: GrantFiled: May 24, 2017Date of Patent: January 21, 2020Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO., LTD.Inventors: Lingjie Chen, Wenling Zhang, Peng Wang
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Publication number: 20190152945Abstract: Provided is a purifying method for dabigatran etexilate free base, comprising subjecting a dabigatran etexilate free base crude product to water slurrying to obtain a crude product B; then conducting recrystallization on the crude product B with acetone and water to obtain a crude product C; and subsequently, purifying the crude product C with a mixed solvent of tetrahydrofuran and ethyl acetate, filtering and drying to obtain a dabigatran etexilate free base finished product. The purifying method of the present invention can effectively remove various impurities and is suitable for workshop production. Salts and water-soluble organic impurities are removed by purified water slurrying, impurities with a high polarity are removed by purifying with an acetone-water solution, and impurities with a low polarity are removed by purifying with a mixed solvent of tetrahydrofuran and ethyl acetate.Type: ApplicationFiled: May 24, 2017Publication date: May 23, 2019Inventors: Lingjie CHEN, Wenling ZHANG, Peng WANG
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Publication number: 20190152894Abstract: Provided is a method for preparing a pregabalin intermediate 3-isobutylglutaric acid monoamide. The method comprises: 1) adding 3-isobutylglutaric acid and urea into a first organic solvent; 2) keeping warm and refluxing when heated to 100-140° C.; 3) adding water when cooled to 70-90° C.; 4) adding an ion membrane alkaline when cooled to 40-60° C., adjusting the pH to 11.0-14.0, then keeping warm at 40-60° C.; 5) when finished keeping warm, removing an organic layer; 6) adding an acid into the water layer to adjust the pH to 1.0-3.0; 7) extracting the solution acquired in step 6) by using a second organic solvent of a total volume of V, vacuum distilling 0.5-0.6 V of the organic solvent from an organic layer acquired by extraction; and 8) cooling to 0-15° C. and crystallizing to acquire 3-isobutylglutaric acid monoamide.Type: ApplicationFiled: June 21, 2017Publication date: May 23, 2019Applicants: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO., LTDInventors: Pan GUO, Musong LIU, Zengle ZHOU, Wenling ZHANG, Peng WANG
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Patent number: 10173965Abstract: The present invention provides a method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust pH; d) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.Type: GrantFiled: March 25, 2016Date of Patent: January 8, 2019Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.Inventors: Musong Liu, Wenling Zhang, Peng Wang
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Patent number: 10131625Abstract: The present invention provides a method for recycling 3-carbamoylmethyl-5-methylhexanoic acid from 3-carba carbamoylmethyl moymethyl-5-methylhexanoic acid chiral resolving mother liquor. The method comprises the following steps: (a) distilling 3-carbamoylmethyl-5-methylhexanoic acid chiral resolving mother liquor, adding aromatic hydrocarbon, heating to dissolve, keeping the temperature and stirring; (b) after completing the reaction in step (a), cooling the reaction solution to 30-60° C., then adding alkali liquor dropwise, keeping the temperature and reacting; and (c) after completing the reaction in step (b), cooling the reactant to 20-30° C., layering, adjusting the pH of the separated water layer to 1 to 2, performing extraction by using an organic solvent, distilling an organic phase under a reduced pressure, and crystallizing at 0±5° C. to obtain 3-carbamoylmethyl-5-methylhexanoic acid.Type: GrantFiled: October 13, 2015Date of Patent: November 20, 2018Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd.Inventors: Shudong Wang, Xuehai You, Wenling Zhang
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Publication number: 20170369422Abstract: The present invention provides a method for preparing a pregabalin intermediate 3-carbamoymethyl-5-methylhexanoic acid without solvent. The method comprises the following steps: a) cooling an ammonia water system to a certain temperature; b) adding 3-isobutylglutaric anhydride dropwise to the system, then keeping temperature, and reacting; c) after completing the reaction, adding an acid to the system to adjust pH; d) after adjusting pH, cooling, then keeping temperature, crystallizing, then suction filtering and drying; and e) adding a solvent to the dried substance, slurrying, and suction filtering and drying to obtain the final product. The method provided in the present invention for preparing 3-carbamoymethyl-5-methylhexanoic acid is high-yield, green, environmentally-friendly, simple and convenient, and of less pollution.Type: ApplicationFiled: March 25, 2016Publication date: December 28, 2017Inventors: Musong Liu, Wenling Zhang, Peng Wang
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Publication number: 20170334836Abstract: The present invention provides a method for recycling 3-carbamoymethyl-5-methylhexanoic acid from 3-carbamoymethyl-5-methylhexanoic acid chiral resolving mother liquor. The method comprises the following steps: (a) distilling 3-carbamoymethyl-5-methylhexanoic acid chiral resolving mother liquor, adding aromatic hydrocarbon, heating to dissolve, keeping the temperature and stirring; (b) after completing the reaction in step (a), cooling the reaction solution to 30-60° C., then adding alkali liquor dropwise, keeping the temperature and reacting; and (c) after completing the reaction in step (b), cooling the reactant to 20-30° C., layering, adjusting the pH of the separated water layer to 1 to 2, performing extraction by using an organic solvent, distilling an organic phase under a reduced pressure, and crystallizing at 0±5° C. to obtain 3-carbamoymethyl-5-methylhexanoic acid. The method provided in the present invention is convenient to operate, and the recycled product is high in purity (?99.8%) and yield.Type: ApplicationFiled: October 13, 2015Publication date: November 23, 2017Applicant: Zhejiang Huahai Pharmaceutical Co., Ltd.Inventors: Shudong Wang, Xuehai You, Wenling Zhang
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Patent number: 9815801Abstract: The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than or equal to 10% D-isomers to dissolve it, then adding a certain amount of inorganic base, separating solids out after salification, distilling a filtrate after filtration, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate with an acid, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables isomers of the product to be below 0.5%, and produce a yield of more than or equal to 40%, being suitable for industrial production.Type: GrantFiled: February 15, 2015Date of Patent: November 14, 2017Assignee: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.Inventors: Yongbi Chen, Wenling Zhang, Peng Wang, Jian Chen
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Publication number: 20160347723Abstract: The present invention relates to a method of refining valsartan comprising more than or equal to 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than or equal to 10% D-isomers to dissolve it, then adding a certain amount of inorganic base, separating solids out after salification, distilling a filtrate after filtration, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate with an acid, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables isomers of the product to be below 0.5%, and produce a yield of more than or equal to 40%, being suitable for industrial production.Type: ApplicationFiled: February 15, 2015Publication date: December 1, 2016Inventors: Yongbi Chen, Wenling Zhang, Peng Wang, Jian Chen
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Patent number: 9067965Abstract: A method for preparing rocuronium is disclosed. 2?-(4-Morpholinyl)-16?-(1-pyrrolidinyl)-5?-androstan-3?-ol-17?-acetate is used as a starting material and is directly reacted with 3-bromopropene at ambient temperature to produce rocuronium.Type: GrantFiled: January 26, 2011Date of Patent: June 30, 2015Assignee: Zhejiang Huahai Pharmaceutical Co., Ltd.Inventors: Zhiwen Zeng, Wenling Zhang, Peng Wang, Xini Zhang