Abstract: The present invention provides compounds, or pharmaceutically acceptable salts, esters, optical isomers, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites, chelates, complexes, clathrates, or prodrugs thereof, and pharmaceutical compositions containing the compounds of the invention. Also provides the application of the compounds in preparing SHP2 phosphatase related disease medicaments. The present invention also provides a method for treating a SHP2 phosphatase-Related disease.

Abstract: A cooling system for an electric motor that includes a stator having a plurality of slot windings and a rotor, coaxial with the stator, having a plurality of magnets, includes a coolant inlet to the motor and a coolant outlet from the motor. A coolant pathway is in fluid communication with the inlet and the outlet. Heat is transferable from the slot windings to the coolant pathway. A coolant flows through the coolant pathway and is in a liquid phase as it enters the coolant inlet, changing into a gaseous phase as heat is transferred to the coolant from the slot windings. A cooling loop is in fluid communication with the coolant inlet and the coolant outlet. The cooling loop cools the coolant so that substantially all of the coolant is in the liquid phase when it enters the coolant inlet.

Abstract: Provided is the following compound or a pharmaceutically acceptable salt, ester, optical isomer, stereoisomer, polymorphic substance, solvate, N-oxide, isotope-labeled compound, metabolite, chelate, coordination complex, inclusion compound or prodrug thereof, and a pharmaceutical composition comprising the compound. Also provided is an application of the compound in preparing a drug for a disease associated with SHP2 phosphatase. Also provided is a method for treating a disease associated with SHP2 phosphatase.

Abstract: A boric acid derivative of a ?-lactamase inhibitor as represented by formula I, or a pharmaceutically acceptable salt thereof. and a stereoisomer and a rotamer or a tautomer or a deuterated compound of the derivative and salt. The boric acid derivative can be used to treat bacterial infections.

Abstract: A manual tweezer, including a main body, a first fixing base, a pushing member, a pull rod, and clamping arms, wherein the first fixing base is arranged on one side of the main body, and the pushing member is movably sleeved on the first fixing base to reciprocate relative to an axial direction of the first fixing base, and wherein the pull rod is respectively provided with a first end and a second end, the first end of the pull rod is fixedly connected to the pushing member, the second end of the pull rod is connected to the clamping arms, and the pushing member drives the pull rod to reciprocate along the axial direction of the first fixing base for driving the clamping arms to open and close. The manual tweezer further includes a silicone sleeve sleeved on the pushing member.

Abstract: The present disclosure relates to benzimidazole derivatives, a preparation method therefor and a medical use thereof. Specifically, the present disclosure relates to a benzimidazole derivative represented by the general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, in particular its use for the treatment of diseases related to P2X3 activity.

Abstract: The present invention discloses an aurilave, including: a water storage tank provided with a mounting port; a housing detachably arranged on the mounting port of the water storage tank; and an ear-washing assembly including a control plate arranged in the housing, a water-pumping motor arranged in the housing and electrically connected to the control plate, a water inlet pipe connected to a water inlet port of the water-pumping motor at one end thereof, a water outlet pipe connected to a water outlet port of the water-pumping motor at one end thereof, a nozzle arranged on the water outlet port of the water outlet pipe, and a transparent water baffle arranged on the water outlet pipe.

Abstract: A radio frequency amplifier includes a first input terminal, a second input terminal, an output terminal, and first and second amplifiers. The first amplifier includes a first amplifier input coupled to the first input terminal, and a first amplifier output. The second amplifier includes a second amplifier input coupled to the second input terminal, and a second amplifier output coupled to the output terminal by an output inductive element. An output combiner circuit is coupled between the first amplifier output and the second amplifier output. The output combiner circuit includes a first inductive element, a capacitor, and a second inductive element. The first inductive element is coupled between the first amplifier output and a first terminal of the capacitor, and the second inductive element is coupled between the second amplifier output and the first terminal of the capacitor. A second terminal of the capacitor is coupled to ground.

Abstract: An amplifier includes a transistor, an input circuit coupled between an amplifier input and a transistor input terminal, and an output circuit coupled between a transistor output and a transistor output terminal. The input circuit includes an input-side harmonic termination circuit with a first inductor and a first capacitance in series between the transistor input terminal and ground. The output circuit includes a second inductor, an output-side harmonic termination circuit, and a shunt-L circuit. The second inductor is coupled between the transistor output terminal and the amplifier output. The output-side harmonic termination circuit includes a third inductor and a second capacitance in series between the amplifier output and ground. The shunt-L circuit includes a fourth inductor and a third capacitance connected in series between the amplifier output and ground.

Abstract: Embodiments of a thin film protective barrier for an encapsulated electronic device is disclosed. The barrier is applied as a thin film coating onto a moisture-sensitive microelectronic device, such as an OLED. A density of the barrier is varied during fabrication, allowing the barrier to flex in applications that demand that the encapsulated electronic device be flexible, while providing a highly-resistant barrier to moisture, oxygen and other contaminants.

Abstract: A cooling system for an electric motor that includes a stator having a plurality of slot windings and a rotor, coaxial with the stator, having a plurality of magnets, includes a coolant inlet to the motor and a coolant outlet from the motor. A coolant pathway is in fluid communication with the inlet and the outlet. Heat is transferable from the slot windings to the coolant pathway. A coolant flows through the coolant pathway and is in a liquid phase as it enters the coolant inlet, changing into a gaseous phase as heat is transferred to the coolant from the slot windings. A cooling loop is in fluid communication with the coolant inlet and the coolant outlet. The cooling loop cools the coolant so that substantially all of the coolant is in the liquid phase when it enters the coolant inlet.

Abstract: A visual dental irrigator relates to the technical field of dental cleaning equipment, including: a casing; a water tank detachably mounted on one end of the casing; a cleaning head mounted on the other end of the casing; a camera mounted on one end of the casing adjacent to the cleaning head; a flow amount control assembly provided inside the casing and connected between the cleaning head and the water tank; a control motherboard electrically connected to the camera and the flow amount control assembly; a communication module provided on the control motherboard for information transmission; and an operation button and a power source electrically connected to the control motherboard. The above technical solution has the advantages of assisting oral observation, effectively cleaning the oral cavity, and improving the dental cleaning experience.

Abstract: An amplifier includes a transistor, an input circuit coupled between an amplifier input and a transistor input terminal, and an output circuit coupled between a transistor output and a transistor output terminal. The input circuit includes an input-side harmonic termination circuit with a first inductor and a first capacitance in series between the transistor input terminal and ground. The output circuit includes a second inductor, an output-side harmonic termination circuit, and a shunt-L circuit. The second inductor is coupled between the transistor output terminal and the amplifier output. The output-side harmonic termination circuit includes a third inductor and a second capacitance in series between the amplifier output and ground. The shunt-L circuit includes a fourth inductor and a third capacitance connected in series between the amplifier output and ground.

Abstract: A method to enhance retention times for electrochromic devices. In one embodiment, an electrochromic device described herein is formed having a multilayered electrolyte layer, rather than a single layer normally used in prior art electrochromic devices. The use of a multi-layered electrolyte layer helps minimize the deleterious effects of pinholes and other defects in the electrolyte layer and significantly improve the retention time for colored and/or bleached states in such electrochromic devices.

Abstract: A system and method of forming a silicon-hybrid anode material. The silicon-hybrid anode material including a microparticle mixture of a quantity of silicon microparticles and a quantity of metal microparticles intermixed with the quantity of silicon microparticles in a selected ratio. The microparticle mixture is formed in a silicon-hybrid anode material layer having a thickness of between about 2 and about 15 ?m.

Abstract: A system and method of forming a silicon-hybrid anode material. The silicon-hybrid anode material including a microparticle mixture of a quantity of silicon microparticles and a quantity of metal microparticles intermixed with the quantity of silicon microparticles in a selected ratio. The microparticle mixture is formed in a silicon-hybrid anode material layer having a thickness of between about 2 and about 15 ?m.