Patents by Inventor Wenqing Yao

Wenqing Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
    Publication number: 20200407357
    Abstract: Disclosed are compounds of Formula (I?), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Application
    Filed: September 11, 2020
    Publication date: December 31, 2020
    Inventors: Neil Lajkiewicz, Liangxing Wu, Wenqing Yao
  • THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
    Publication number: 20200405702
    Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 31, 2020
    Inventors: Chu-Biao Xue, Yun-Long Li, Hao Feng, Jun Pan, Anlai Wang, Ke Zhang, Wenqing Yao, Fenglei Zhang, Jincong Zhuo
  • Heteroaryl amide compounds as sting activators
    Patent number: 10875872
    Abstract: The present application provides heteroaryl amide compounds that activate the STING pathway to produce interferons, which are useful in the treatment of various diseases including infectious diseases and cancer.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: December 29, 2020
    Assignee: Incyte Corporation
    Inventors: Liangxing Wu, Neil Lajkiewicz, Wenqing Yao
  • IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE
    Publication number: 20200397893
    Abstract: Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1-related disease or condition.
    Type: Application
    Filed: September 1, 2020
    Publication date: December 24, 2020
    Inventors: Phillip C. Liu, Alla Volgina, Richard Wynn, Nina Zolotarjova, Liangxing Wu, Kaijiong Xiao, Song Mei, Liang Lu, Wenyu Zhu, Yingda Ye, Haisheng Wang, Ding-Quan Qian, Wenqing Yao
  • SULFONYLAMIDE COMPOUNDS AS CDK2 INHIBITORS
    Publication number: 20200399273
    Abstract: The present application provides sulfonyl amide compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: March 27, 2020
    Publication date: December 24, 2020
    Inventors: Alexander Sokolsky, Sarah Winterton, Liangxing Wu, Wenqing Yao, Min Ye, Yingnan Chen, Margaret Favata, Yvonne Lo
  • BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
    Publication number: 20200399267
    Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.
    Type: Application
    Filed: July 9, 2020
    Publication date: December 24, 2020
    Inventors: Liang Lu, Liangxing Wu, Ding-Quan Qian, Wenqing Yao
  • HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS
    Publication number: 20200392143
    Abstract: The present invention is directed to compounds of Formula I which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
    Type: Application
    Filed: August 28, 2020
    Publication date: December 17, 2020
    Inventors: Chunhong He, Zhenwu Li, Liangxing Wu, Wenqing Yao, Fenglei Zhang
  • PYRROLO[2,3-D]PYRIMIDINONE COMPOUNDS AS CDK2 INHIBITORS
    Publication number: 20200392139
    Abstract: The present application provides pyrrolo[2,3-d]pyrimidinone inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: February 14, 2020
    Publication date: December 17, 2020
    Inventors: Alexander Sokolsky, Sarah Winterton, Liangxing Wu, Wenqing Yao
  • SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS
    Publication number: 20200377504
    Abstract: The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.
    Type: Application
    Filed: April 7, 2020
    Publication date: December 3, 2020
    Inventors: Liangxing Wu, Colin Zhang, Chunhong He, Yaping Sun, Liang Lu, Ding-Quan Qian, Meizhong Xu, Jincong Zhuo, Wenqing Yao
  • Bicyclic heterocycles as FGFR4 inhibitors
    Patent number: 10851105
    Abstract: The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: December 1, 2020
    Assignee: Incyte Corporation
    Inventors: Liangxing Wu, Liang Lu, Ding-Quan Qian, Bo Shen, Wenqing Yao
  • Item recommendation method, device, and system
    Patent number: 10838985
    Abstract: An item recommendation system includes a candidate item database system, a communication module, and a processor. Candidate items to be recommended to a user are stored in the candidate item database system in association with the access items accessed by the user. The communication module acquires one or more access items accessed by the user recently. The processor acquires one or more candidate items and correlation indexes thereof from the candidate item database system based on the one or more access items, and generates an item recommendation list, wherein the item recommendation list comprises the one or more candidate items and recommendation weights thereof, and the recommendation weights are determined based on the correlation indexes.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 17, 2020
    Assignee: Guangzhou UCWeb Computer Technology Co., Ltd.
    Inventors: Wenqing Yao, Rongshen Long
  • TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS
    Publication number: 20200347067
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Qinda Ye, Neil Lajkiewicz, Ken Mukai, Liangxing Wu, Wenqing Yao
  • TRICYCLIC AMINE COMPOUNDS AS CDK2 INHIBITORS
    Publication number: 20200347066
    Abstract: The present application provides tricyclic amine compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
    Type: Application
    Filed: April 30, 2020
    Publication date: November 5, 2020
    Inventors: Qinda Ye, Ken Mukai, Liangxing Wu, Wenqing Yao
  • Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
    Patent number: 10813930
    Abstract: The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are FGFR3 inhibitors useful in the treatment of cancer and other diseases.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: October 27, 2020
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Wenqing Yao, Colin Zhang, Meizhong Xu, Jincong Zhuo, Chunhong He
  • HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
    Publication number: 20200325115
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 15, 2020
    Inventors: Liangxing Wu, Zhiyong Yu, Fenglei Zhang, Wenqing Yao
  • HETEROCYCLYLAMINES AS PI3K INHIBITORS
    Publication number: 20200323858
    Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Application
    Filed: March 24, 2020
    Publication date: October 15, 2020
    Inventors: Yun-Long Li, Wenqing Yao, Andrew P. Combs, Eddy W. Yue, Song Mei, Joseph Glenn, Thomas P. Maduskuie, Jr., Richard B. Sparks, Brent Douty, Chunhong He
  • Heterocyclic compounds as immunomodulators
    Patent number: 10800768
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 13, 2020
    Assignee: Incyte Corporation
    Inventors: Liangxing Wu, Jingwei Li, Wenqing Yao, Chao Qi, Ding-Quan Qian, Fenglei Zhang
  • Heterocyclic compounds as LSD1 inhibitors
    Patent number: 10800779
    Abstract: The present invention is directed to compounds of Formula I which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: October 13, 2020
    Assignee: Incyte Corporation
    Inventors: Chunhong He, Zhenwu Li, Liangxing Wu, Wenqing Yao, Fenglei Zhang
  • Carboxamide compounds and uses thereof
    Patent number: 10800761
    Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: October 13, 2020
    Assignee: Incyte Corporation
    Inventors: Oleg Vechorkin, Jun Pan, Alexander Sokolsky, Evan Styduhar, Wenqing Yao
  • CYCLIN-DEPENDENT KINASE 2 BIOMARKERS AND USES THEREOF
    Publication number: 20200316064
    Abstract: Biomarkers are provided that are predictive and/or indicative of a subject's responsiveness to a cyclin-dependent kinase 2 (CDK2) inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing a disease or disorder associated with CDK2 and for monitoring treatment.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 8, 2020
    Inventors: Min Ye, Yingnan Chen, Margaret Favata, Yvonne Lo, Alexander Sokolsky, Sarah Winterton, Liangxing Wu, Wenqing Yao