Patents by Inventor Wensheng ZHANG

Wensheng ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250139330
    Abstract: A method for determining the predicting sealing performance of a joint having a sealant positioned between a first member and a second member. The method includes selecting a sealant material for the sealant, selecting a first member material for the first member and a second member material for the second member, and subjecting the joint, using finite elemental analysis (FEA), to high cycle loads and low cycle loads.
    Type: Application
    Filed: October 25, 2023
    Publication date: May 1, 2025
    Inventor: Wensheng Zhang
  • Patent number: 12221414
    Abstract: A quaternary ammonium salt compound of formula I is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound of formula I and the pharmaceutically acceptable salt thereof can be used for the preparation of saft drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: February 11, 2025
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Bowen Ke, Jin Liu, Wensheng Zhang, Jun Yang
  • Publication number: 20250010515
    Abstract: A method and an apparatus for high-throughput preparation of a cement-based material are released and belong to the technical field of cement production. According to the technical solution of the present application, a single-mine, a single-phase or a unit components maintaining specific hydration hardening characteristics are used as structural units, and the method comprises the following steps that (1) the structural units are placed in storage tubes X1, X2, X3 . . . Xn respectively; (2) the materials in the storage pipes are put according to the composition design proportion of the cement-based material, and Y1, Y2, Y3 . . . Ym of mixed materials are prepared; (3) fully and uniformly mixing the Y1, Y2, Y3 . . . Ym of mixed materials through a uniform mixing device; and 4) respectively filling the Y1, Y2, Y3 . . . Ym of uniformly mixed materials into storage tanks Z1, Z2, Z3 . . . Zm to prepare m groups of cement-based material samples.
    Type: Application
    Filed: March 1, 2023
    Publication date: January 9, 2025
    Inventors: Xuehong REN, Jiayuan YE, Xiao ZHI, Hongtao ZHANG, Di SHI, Wensheng ZHANG, Zhaijun WEN
  • Publication number: 20240190763
    Abstract: A belite-ye'elimite-ternesite cement clinker includes: ye'elimite: 20-50 wt. %; ternesite: 24-50 wt. %; belite: 10-35 wt. %; and free-calcium sulfate (f-C$): 2-10 wt. %. The composition of cement clinker includes an appropriate amount of ye'elimite minerals, ensuring fast early hydration and high early strength of the cement clinker. The cement clinker further includes a certain amount of free-calcium sulfate (f-C$), and is characterized by its good grindability, leading to decreased energy and mechanical losses essential for clinker grinding. This environmentally conscious and energy-efficient method aligns with the global objective of reducing carbon emissions.
    Type: Application
    Filed: December 12, 2023
    Publication date: June 13, 2024
    Inventors: Lixue CAO, Xuehong REN, Wensheng ZHANG, Jiayuan YE, Hongtao ZHANG, Nan AN, Wenjuan CUI
  • Publication number: 20240190764
    Abstract: A low-carbon cement clinker, having the following parameter ranges: alkalinity coefficient C: 1.0?C?1.5; aluminum-sulfur ratio P: P<1.92; aluminum-silicon ratio N: N<1; and limestone saturation coefficient Cs: 0.9?Cs<1.0. The specific range of each parameter value ensures an idea ratio of mineral composition in the low-carbon cement clinker. The ratio promotes a coordinated interaction among different minerals and compounds present when exposed to water, leading to improved strength development and overall performance of the final cement product.
    Type: Application
    Filed: December 11, 2023
    Publication date: June 13, 2024
    Inventors: Xuehong REN, Lixue CAO, Xiao ZHI, Wensheng ZHANG, Jiayuan YE, Nan AN, Hongtao ZHANG, Wenjuan CUI
  • Publication number: 20240052905
    Abstract: A shock absorber for an automobile with adaptive damping includes a cylinder barrel, a piston rod, a damping valve, a nitrogen container and a flute tube assembly. The flute tube assembly includes a core tube socket, an inner tube and an outer tube. A row of damping through holes is formed in each of two ends of the outer tube, a first check valve is arranged at one end of the outer tube and inserted into the piston rod, and the other end of the outer tube is arranged on the core tube socket and is connected to the nitrogen container through a first oil tube pipeline; the core tube socket is communicated with the first oil tube pipeline through a second check valve; the bottom end of the inner tube is fixed to the core tube socket and connected to the nitrogen container through a second oil tube pipeline.
    Type: Application
    Filed: December 31, 2021
    Publication date: February 15, 2024
    Applicant: BAODING DONGLI MACHINERY CO., LTD
    Inventors: Zheng WANG, Dongbo WANG, Hui LI, Zhengli TIAN, Shaonan GU, Guang GU, Wensheng ZHANG, Mingkai YU, Xun ZHANG
  • Publication number: 20230400301
    Abstract: The present disclosure discloses a tropical instability wave early warning method based on temporal-spatial cross-scale attention fusion, including performing cross-scale spatial map fusion on the multi-scale feature maps by a bilateral local attention mechanism, calculating a prediction loss by the global feature description map, and combining the prediction loss and the regularization loss for optimization training of neural networks; predicting a sea surface temperature at a moment T based on the optimally trained neural networks, selecting data at K moments before the moment T and inputting the data into the optimally trained neural networks, outputting a predicted value of tropical instability waves by the optimally trained neural networks, and drawing a temporal-spatial image of the tropical instability waves by associating the predicted value with coordinates, so as to achieve early warning of the tropical instability waves. The device includes a processor and a memory.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 14, 2023
    Inventors: Dan SONG, Zhenghao FANG, Anan LIU, Wenhui LI, Zhiqiang WEI, Jie NIE, Wensheng ZHANG, Zhengya SUN
  • Publication number: 20230393304
    Abstract: The present invention discloses an El Nino extreme weather warning method based on incremental learning, comprising: through supervised representation learning, selectively constraining, by a multi-scale feature frequency domain distillation technology, drift of low-frequency components of the multi-scale features based on incremental training, and memorizing knowledge learned by the parallel convolutional neural networks in old tasks; adaptively learning different fusion parameters according to different time spans of the input multi-scale data by using a multi-scale feature adaptive fusion technology, so as to enhance the ability to learn new tasks; and outputting a Nino3.4 index reflecting a change rule of El Nino through fully connected layers according to the adaptively fused features, establishing a mapping function of an extreme rainfall probability r based on the Nino3.4 index, and in response to predicting that the value r goes beyond a threshold value k.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 7, 2023
    Inventors: Anan LIU, Haochun LU, Wenhui LI, Dan SONG, Zhiqiang WEI, Jie NIE, Wensheng ZHANG, Zhengya SUN
  • Patent number: 11697639
    Abstract: A compound is shown in formula I and can be in the form of a pharmaceutically acceptable salt, or a stereoisomer, or a solvate, or a prodrug, or a metabolite. The compound takes effect rapidly and has a long-time local anesthetic effect following a single dose, with the sensory nerve blocking time being greater than the motor nerve blocking time, has both a long-acting local anesthetic effect and a selective local anesthetic effect, significantly reduces side effects of the compositions QX314 and QX314 and a quaternary ammonium salt compound with surfactant structural characteristics, and is safer. The compound of formula I of the present invention and a pharmaceutically acceptable salt thereof can be used for preparing drugs that have a long-time local anesthetic effect and a selective local anesthetic effect.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 11, 2023
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Jin Liu, Bowen Ke, Wensheng Zhang, Jun Yang, Lei Tang
  • Publication number: 20230026724
    Abstract: Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and/or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art.
    Type: Application
    Filed: October 10, 2020
    Publication date: January 26, 2023
    Inventors: Jin LIU, Wensheng ZHANG, Haijun MA, Changhua WANG, Zhenbiao XIE
  • Patent number: 11525384
    Abstract: A bolted joint for coupling two components that undergo thermal expansion and contraction includes a bolt having a head and a stem, the bolt configured to provide a clamping force between the two components. A first washer having a thermal resistant, low friction coating is configured to be disposed between one of the two components and the bolt head to enable the one component to slide relative to the bolt during the thermal expansion and contraction, while maintaining the clamping force, to facilitate preventing bending or shearing of the bolt.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: December 13, 2022
    Assignee: FCA US LLC
    Inventors: Wensheng Zhang, Rohit Paranjpe, Yi-Hsin Chen, Kanwerdip Singh
  • Patent number: 11459298
    Abstract: A dication compound represented by formula (I), stereoisomers having the structure of formula (I) or a mixture of the stereoisomers, a pharmaceutically acceptable salt, a solvate, or a eutectic crystal, and a composition thereof, and use of a composition, are capable of producing neuromuscular junction retardation, formed of same with a pharmaceutically acceptable carrier in the field of preparation of a medicament for muscular flaccidity.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: October 4, 2022
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Jin Liu, Jun Yang, Wensheng Zhang, Bowen Ke, Weiyi Zhang, Cheng Zhou, Lei Tang
  • Publication number: 20220135526
    Abstract: A quaternary ammonium salt compound of formula I is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound of formula I and the pharmaceutically acceptable salt thereof can be used for the preparation of saft drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect
    Type: Application
    Filed: January 21, 2020
    Publication date: May 5, 2022
    Inventors: Bowen KE, Jin LIU, Wensheng ZHANG, Jun YANG, Lei TANG
  • Patent number: 11208385
    Abstract: An N-substituted imidazole carboxylate compound is of formula (I). In formula (I), C* is an R-type chiral carbon atom, R1 and R2 are independently selected from H, methyl, ethyl, cyclopropyl, cyclobutyl or isopropyl, or R1 and R2 form a C2˜5 alkylenyl group; R3 is a substituted or unsubstituted C1-18 saturated or unsaturated aliphatic hydrocarbon or aromatic hydrocarbon, in which the aliphatic hydrocarbon comprises a straight chain, branched chain or cyclic aliphatic hydrocarbyl. The compound or pharmaceutically acceptable salts thereof can be used to prepare central inhibitory drugs that exert sedative, hypnotic and/or anesthetic effects on humans or animals, and can produce rapid and reversible anesthetic effects, and can be rapidly metabolized into an inactive etomidate acid, and after drug withdrawal, the wake-up quality is good; and the body's corticosteroid function can be rapidly recovered after a single administration or continuous administration.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: December 28, 2021
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Jin Liu, Jun Yang, Wensheng Zhang, Bowen Ke, Lei Tang, Bin Wang
  • Patent number: 11161828
    Abstract: A two-quaternary ammonium compound has a structural formula of formula (I). L1 is a C1 to C8 alkylene group; L2 is a C1 to C8 alkylene group; Z1 is nitro group or a halogen or methoxy group; Z2 is nitro group or a halogen or methoxy group; Z3 is nitro group or a halogen or methoxy group; R?H or a C1 to C6 alkyl group; a, b, and c are independently an integer from 0-5; and M is a pharmaceutically acceptable anion, such as a bromine ion, chlorine ion, sulfonate radical, etc. A stereoisomer or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate or eutectic of the compound of formula (I) forms a composition with a pharmaceutically acceptable carrier, or forms a compounded prescription with other active components, and the composition or compounded prescription may be used in the preparation of a muscle relaxant.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: November 2, 2021
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Jun Yang, Jin Liu, Weiyi Zhang, Wensheng Zhang, Cheng Zhou, Bowen Ke, Lei Tang
  • Publication number: 20210239027
    Abstract: A bolted joint for coupling two components that undergo thermal expansion and contraction includes a bolt having a head and a stem, the bolt configured to provide a clamping force between the two components. A first washer having a thermal resistant, low friction coating is configured to be disposed between one of the two components and the bolt head to enable the one component to slide relative to the bolt during the thermal expansion and contraction, while maintaining the clamping force, to facilitate preventing bending or shearing of the bolt.
    Type: Application
    Filed: February 3, 2020
    Publication date: August 5, 2021
    Inventors: Wensheng Zhang, Rohit Paranjpe, Yi-Hsin Chen, Kanwerdip Singh
  • Publication number: 20210214304
    Abstract: A dication compound represented by formula (I), stereoisomers having the structure of formula (I) or a mixture of the stereoisomers, a pharmaceutically acceptable salt, a solvate, or a eutectic crystal, and a composition thereof, and use of a composition, are capable of producing neuromuscular junction retardation, formed of same with a pharmaceutically acceptable carrier in the field of preparation of a medicament for muscular flaccidity.
    Type: Application
    Filed: July 24, 2019
    Publication date: July 15, 2021
    Inventors: Jin LIU, Jun YANG, Wensheng ZHANG, Bowen KE, Weiyi ZHANG, Cheng ZHOU, Lei TANG
  • Patent number: 11032984
    Abstract: The present invention discloses genes and SNP markers significantly associated with lint percentage trait in cotton, and use thereof. The genes significantly associated with the lint percentage trait in cotton are genes Gh_D05G1124, Gh_D05G0313, and GhWAKL3. In the present invention, a CottonSNP63K gene array is used for genotyping, and genome re-sequencing data are analyzed to identify SNP markers significantly associated with the lint percentage trait in cotton. Moreover, the present invention also discloses use of the genes and SNP markers, which are significantly associated with the lint percentage trait in cotton, in cotton germplasm identification, breeding, or genetic diversity analysis.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: June 15, 2021
    Assignee: Institute of Cotton Research of the Chinese Academy of Agricultural Sciences
    Inventors: Wei Li, Daigang Yang, Xiongfeng Ma, Xiaoyu Pei, Yangai Liu, Kunlun He, Fei Zhang, Zhongying Ren, Xiaojian Zhou, Wensheng Zhang, Zhenyu Wang, Chengxiang Song, Kuan Sun
  • Patent number: RE49035
    Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: April 19, 2022
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Zhengliang Ye, Shunnan Zhang, Lihong Zhou, Wensheng Zhang, Hai'ou Dong
  • Patent number: RE49050
    Abstract: A traditional Chinese medicine composition for treating cardiovascular disease, and a preparation thereof, particularly a micro drop pill preparation thereof, and a method for preparing the preparation; the method for preparing the micro drop pill preparation can be used to prepare drop pills, coated drop pills, and drop pill capsules with a high drug loading capacity.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: April 26, 2022
    Assignee: Tasly Pharmaceutical Group Co., Ltd.
    Inventors: Xijun Yan, Naifeng Wu, Kaijing Yan, Zhengliang Ye, Shunnan Zhang, Lihong Zhou, Wensheng Zhang, Hai'ou Dong, Yongfeng Zheng, Lijun Fan