Patents by Inventor Wentai Liu
Wentai Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131329Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: ApplicationFiled: October 31, 2023Publication date: April 25, 2024Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Patent number: 11944814Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.Type: GrantFiled: August 27, 2021Date of Patent: April 2, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu, Victor R. Edgerton, Chih-Wei Chang
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Publication number: 20240033521Abstract: A nerve stimulation system includes an electrode, an electrode controlling device coupled to the electrode and configured to control the electrode to electrically stimulate a peripheral nerve according to a nerve stimulation signal, and a signal generating device coupled to the electrode controlling device and configured to generate the nerve stimulation signal. The nerve stimulation signal is a signal with a square envelope. The square envelope periodically includes an on-time period with a pulse amplitude and an off-time period without the pulse amplitude, and a ratio of the on-time period and the off-time period is not less than 1, and a length of the off-time period is not longer than 5 seconds.Type: ApplicationFiled: July 28, 2023Publication date: February 1, 2024Inventors: Yuan-Yu Hsueh, Wentai Liu, Szu Han Chen, Wan-Ling Tseng, CHUN-WEI LIN
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Publication number: 20240017070Abstract: A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current/Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and/or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.Type: ApplicationFiled: June 2, 2023Publication date: January 18, 2024Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NATIONAL CHENG KUNG UNIVERSITYInventors: Wentai Liu, Meng-Ru Shen, Li-Hsien Chen, Ya-Ting Hsu
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Patent number: 11857783Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: GrantFiled: November 12, 2021Date of Patent: January 2, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Publication number: 20230402189Abstract: Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.Type: ApplicationFiled: June 9, 2023Publication date: December 14, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ying Li, Wentai Liu, Yi-Kai Lo
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Patent number: 11715566Abstract: Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.Type: GrantFiled: June 5, 2019Date of Patent: August 1, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ying Li, Wentai Liu, Yi-Kai Lo
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Publication number: 20220409886Abstract: A neural stimulator system which generates stimulation from an implantable stimulator circuit which generates stimulation outputs which mimic biological signals. The user/operator can select stimulation generated from recorded waveforms, or by selecting the characteristics for generating stimulation based on randomized inter-pulse-intervals (IPI). A control unit controls the operation of the implantable stimulator circuit, and receives sets of stimulation parameters based on user input from a user input device executing application specific programming.Type: ApplicationFiled: July 19, 2022Publication date: December 29, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Wentai Liu, Stanislav Culaclii, Po-Min Wang, Yi-Kai Lo
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Patent number: 11389644Abstract: A flexible thin film metal oxide electrode fabrication methods and devices are provided and illustrated with thin film polyimide electrode formation and IrOx chemical bath deposition. Growth factors of the deposited film such as film thickness, deposition rate and quality of crystallites can be controlled by varying the solution pH, temperature and component concentrations of the bath. The methods allow for selective deposition of IrOx on a flexible substrate (e.g. polyimide electrode) where the IrOx will only coat onto an exposed metal area but not the entire device surface. This feature enables the bath process to coat the IrOx onto every individual electrode in one batch, and to ensure electrical isolation between channels. The ability to perform selective deposition, pads for external connections will not have IrOx coverage that would otherwise interfere with a soldering/bumping process.Type: GrantFiled: May 6, 2019Date of Patent: July 19, 2022Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NATIONAL CHIAO TUNG UNIVERSITYInventors: Wentai Liu, Chih-Wei Chang, Pu-Wei Wu, Chung-Yu Wu, Po-Chun Chen, Tsai-Wei Chung
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Publication number: 20220152386Abstract: A disposable implant that may be positioned inside the gastrointestinal (GI) tract through laparotomy or laparoscopic surgery. The implant may be secured in place using a biodegradable glue or biodegradable suture and is naturally expelled from the body with bowel movement after a certain period of time. In one embodiment, GI implant comprises a coil that receives power from, and sends the recorded physiological information to, an external device through wireless inductive coupling.Type: ApplicationFiled: February 8, 2022Publication date: May 19, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Publication number: 20220134100Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI),a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: ApplicationFiled: November 12, 2021Publication date: May 5, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Publication number: 20220040479Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.Type: ApplicationFiled: August 27, 2021Publication date: February 10, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu, Victor R. Edgerton, Chih-Wei Chang
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Publication number: 20220016420Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.Type: ApplicationFiled: August 27, 2021Publication date: January 20, 2022Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu, Victor R. Edgerton, Chih-Wei Chang
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Patent number: 11202907Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI),a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: GrantFiled: June 11, 2019Date of Patent: December 21, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Patent number: 11129983Abstract: A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.Type: GrantFiled: July 24, 2018Date of Patent: September 28, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu, Victor R. Edgerton, Chih-Wei Chang
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Patent number: 11042982Abstract: An ultra-dense electrode-based brain imaging system with high spatial and temporal resolution. A Sparsity and Smoothness enhanced Method Of Optimized electrical TomograpHy (s-SMOOTH) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images is described. Also described is a graph Fractional-Order Total Variation (gFOTV) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images.Type: GrantFiled: March 5, 2018Date of Patent: June 22, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Wentai Liu, Ying Li, Jing Qin, Chi-Wei Chang, Yi-Kai Lo
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Patent number: 10773074Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.Type: GrantFiled: August 27, 2015Date of Patent: September 15, 2020Assignee: The Regents of the University of CaliforniaInventors: Wentai Liu, Victor Reggie Edgerton, Chih-Wei Chang, Parag Gad
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Patent number: 10583285Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.Type: GrantFiled: August 27, 2015Date of Patent: March 10, 2020Assignee: The Regents of the University of CaliforniaInventors: Wentai Liu, Chih-Wei Chang
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Publication number: 20190358450Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI),a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.Type: ApplicationFiled: June 11, 2019Publication date: November 28, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Yi-Kai Lo, Wentai Liu
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Publication number: 20190355476Abstract: Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.Type: ApplicationFiled: June 5, 2019Publication date: November 21, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ying Li, Wentai Liu, Yi-Kai Lo