Patents by Inventor Wenxuan Wu

Wenxuan Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12174140
    Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 24, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Donhee Ham, Hongkun Park, Keith Krenek, Tianyang Ye, Jeffrey T. Abbott, Wenxuan Wu
  • Publication number: 20240385168
    Abstract: Measurement devices include: a substrate; a plurality of integrated circuits, each featuring a plurality of electrodes, and the plurality of integrated circuits being positioned on the substrate in a two-dimensional array including n rows and m columns; a communication interface connected to each of the plurality of integrated circuits so that each integrated circuit is addressable through the interface; and a data output interface featuring multiple data output lines connected to the communication interface, where in each of the n rows of the array, the integrated circuits are connected to a common data line, and the measurement device is configurable, responsive to a control signal, to transmit measurement information through the data output interface by, in one or more of the n rows of the array, selectively transmitting measurement information from one of the integrated circuits connected to the row's common data line to the data output interface.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Inventors: Alexander Alexeyev, Mickey Cheah, Zach Boynton, Wenxuan Wu, Jeffrey Abbott
  • Publication number: 20240255461
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Application
    Filed: August 31, 2023
    Publication date: August 1, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Hongkun Park, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Donhee Ham
  • Publication number: 20240219370
    Abstract: Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.
    Type: Application
    Filed: August 3, 2023
    Publication date: July 4, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Jeffrey T. Abbott, Hongkun Park, Wenxuan Wu
  • Publication number: 20240210380
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Application
    Filed: August 3, 2023
    Publication date: June 27, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Hongkun Park
  • Patent number: 11774396
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: October 3, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Hongkun Park, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Donhee Ham
  • Patent number: 11768196
    Abstract: Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: September 26, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Donhee Ham, Jeffrey T. Abbott, Hongkun Park, Wenxuan Wu
  • Patent number: 11747321
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Grant
    Filed: July 29, 2022
    Date of Patent: September 5, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Donhee Ham, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Hongkun Park
  • Publication number: 20230184739
    Abstract: Disclosed herein are semiconductor devices to provide a CMOS-compatible, wafer-scale, multi-well platform that can be used for biomedical or other applications, and methods to operate the same. In some embodiments, circuitry is provided underneath a multiple-well array to electrically interface with electrodes in the wells. To interface with electrodes in a large array, circuitry may be fabricated on a single silicon (Si) wafer having a dimension that is at least the same or larger than that of the multiple-well array. According to one aspect of the present disclosure, standard CMOS fabrication process such as those known to be used in a standard semiconductor foundry may be used without expensive customization for complex fabrication procedures. This may help the production cost to be lowered in some cases.
    Type: Application
    Filed: August 19, 2022
    Publication date: June 15, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Wenxuan Wu, Jeffrey T. Abbott, Henry Julian Hinton, Hongkun Park
  • Publication number: 20230084369
    Abstract: Provided are a configuration updating method and apparatus, a device, and a storage medium. The method is applied to an edge device and includes that: identification information of a configuration file to be updated in the edge device and first version information of the configuration file are acquired, the configuration file at least including an image, collected by a collection apparatus, of a game region and a parameter of the collection apparatus; second version information of a configuration file in a cloud server is acquired based on the identification information; the configuration file of the second version information is acquired from the cloud server in a case where the second version information is higher than the first version information; and the configuration file in the edge device is updated with the configuration file of the second version information.
    Type: Application
    Filed: September 29, 2021
    Publication date: March 16, 2023
    Inventors: Jiacheng WU, Wenxuan Wu, Shuai Zhang
  • Publication number: 20230014082
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Application
    Filed: September 8, 2022
    Publication date: January 19, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Hongkun Park, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Donhee Ham
  • Publication number: 20220406125
    Abstract: The embodiments of the disclosure provide a game state detection and configuration updating method and apparatus, a device and a storage medium. The method includes that: description information of multiple configuration files of a first game table is acquired from a cloud; first description information is determined from the description information of the multiple configuration files, the version of a first configuration file described by the first description information being higher than that of a first local configuration file of the corresponding first game table; the first configuration file is acquired from the cloud to update the first local configuration file; and a game state of the first game table is detected according to the updated first local configuration file, as well as a first image collected for the first game table. The disclosure improves the accuracy of game state detection and the efficiency of configuration updating.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 22, 2022
    Inventors: Jiacheng WU, Shuai ZHANG, Gan XIAO, Xin GAN, Wenxuan WU
  • Publication number: 20220397512
    Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.
    Type: Application
    Filed: July 29, 2022
    Publication date: December 15, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Jeffrey T. Abbott, Wenxuan Wu, Tianyang Ye, Han Sae Jung, Hongkun Park
  • Publication number: 20210371846
    Abstract: Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.
    Type: Application
    Filed: July 6, 2018
    Publication date: December 2, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Donhee Ham, Jeffrey T ABBOTT, Hongkun PARK, Wenxuan WU
  • Publication number: 20200292482
    Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
    Type: Application
    Filed: October 30, 2018
    Publication date: September 17, 2020
    Applicant: President and Fellows of Harvard College
    Inventors: Donhee Ham, Hongkun Park, Keith Krenek, Tianyang Ye, Jeffrey T. Abbott, Wenxuan Wu
  • Publication number: 20100003415
    Abstract: A high voltage ceramic and glass insulator with a function film is provided to resist pollution flashover and a preparation method is provided to produce the high voltage insulators. It is a common high voltage insulator covered with a layer of nano meter level inorganic film with the function of raising pollution flashover resisting, and the film is formed on the high voltage ceramic and glass insulator surface and made of a solution containing the titanium dioxide base, and the solution containing the titanium dioxide base includes a pure titanium dioxide solution or a binary compound oxide solution containing the titanium dioxide. The invention is suitably used for the power transmission and the transform line in the areas with the circumstance seriously polluted or in the remote mountainous areas.
    Type: Application
    Filed: March 30, 2006
    Publication date: January 7, 2010
    Inventors: Xianzhi Fu, Wenlin Zong, Ping Liu, Qian Shi, Wenxin Dai, Fuwang Liao, Xun Chen, Han Lin, Xuxu Wang, Wenxuan Wu, Yu Shao, Xueyong Li, Lixin Sun, Hongxian Chai
  • Patent number: D922463
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: June 15, 2021
    Assignee: ABB Schweiz AG
    Inventors: Bin Liu, Junjie Hu, Zhen Shi, Jiabei Shi, Xingjie Li, Wenxuan Wu, Yusheng Cai, Beibei Chen