Patents by Inventor Wenxue Wu

Wenxue Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 5-alkyl-7H-pyrrolo[2,3-d] pyrimindine-2-ols
    Patent number: 7951941
    Abstract: Methods of preparing 5-alkyl-7H-pyrrolo[2,3-d]pyrimidin-4-ols are described, as are novel compounds useful in their preparation.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: May 31, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark S. Bednarz, Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYLALANINES
    Publication number: 20110124865
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds are disclosed.
    Type: Application
    Filed: November 18, 2010
    Publication date: May 26, 2011
    Inventors: Shinya IIMURA, Wenxue WU, Matthew Mangzhu ZHAO
  • METHODS OF PREPARING 1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE
    Publication number: 20110098482
    Abstract: Methods of preparing 1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone and derivatives thereof are disclosed.
    Type: Application
    Filed: October 25, 2010
    Publication date: April 28, 2011
    Inventor: Wenxue Wu
  • Synthesis of piperazines, piperidines and related compounds
    Patent number: 7919618
    Abstract: Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 5, 2011
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hugh Alfred Burgoon, Jr., Ramanaiah C. Kanamarlapudi, Wenxue Wu
  • METHODS OF PREPARING IMIDAZOLE-BASED COMPOUNDS
    Publication number: 20110071303
    Abstract: Methods of preparing imidazole-based compounds are disclosed.
    Type: Application
    Filed: September 20, 2010
    Publication date: March 24, 2011
    Inventors: Wenxue Wu, Jie Yan, Haiming Zhang
  • Process for the preparation of substituted phenylalanines
    Patent number: 7897763
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: March 1, 2011
  • Process for the preparation of substituted phenylalanines
    Patent number: 7855291
    Abstract: Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 21, 2010
  • MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE
    Publication number: 20100280054
    Abstract: Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
    Type: Application
    Filed: March 30, 2010
    Publication date: November 4, 2010
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Qingyun Liu, Brett Marinelli, Lakshama Samala, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Wenxue Wu, Chengmin Zhang, Haiming Zhang
  • Methods of preparing imidazole-based compounds
    Patent number: 7812174
    Abstract: Methods of preparing imidazole-based compounds are disclosed.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: October 12, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Wenxue Wu, Jie Yan, Haiming Zhang
  • Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines
    Publication number: 20100249411
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Wenxue Wu, Hongbiao Liao, David J.S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • 1-PHENYL-1H-PYRAZOLE-BASED COMPOUNDS
    Publication number: 20100240906
    Abstract: Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 23, 2010
    Inventors: Mark S. Bednarz, Hugh Alfred Burgoon, JR., Shinya Iimura, Ramanaiah C. Kanamarlapudi, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Patent number: 7745626
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: June 29, 2010
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Synthesis of CCR5 receptor antagonists
    Patent number: 7728135
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: June 1, 2010
    Assignee: Schering Corporation
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecelia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS
    Publication number: 20100036125
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • METHODS OF PREPARING IMIDAZOLE-BASED BICYCLIC COMPOUNDS
    Publication number: 20090318705
    Abstract: Methods of preparing compounds of formula I are disclosed:
    Type: Application
    Filed: June 16, 2009
    Publication date: December 24, 2009
    Inventors: Jason Guohua, Weifeng Hu, Renmao Liu, Yuelie Lu, Wenxue Wu, Xiaogen Yang
  • (E)-1-(4-((1R,2S,3R)-1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL)ETHANONE OXIME DIHYDRATE AND METHODS OF ITS USE
    Publication number: 20090298901
    Abstract: (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-ethanone oxime dihydrate, compositions comprising it, and methods of its use are disclosed.
    Type: Application
    Filed: August 6, 2009
    Publication date: December 3, 2009
    Inventors: Wenxue Wu, Haiming Zhang
  • Synthesis of himbacine analogs
    Patent number: 7626045
    Abstract: The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: December 1, 2009
    Assignee: Schering Corporation
    Inventors: Tiruvettipuram K. Thiruvengadam, Tao Wang, Jing Liao, John S. Chiu, David J. S. Tsai, Hong-Chang Lee, Wenxue Wu, Xiaoyong Fu
  • SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20090203925
    Abstract: The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.
    Type: Application
    Filed: April 23, 2009
    Publication date: August 13, 2009
    Inventors: Tiruvettipuram K. Thiruvengadam, Tao Wang, Jing Liao, John S. Chiu, David Jieh-Shyh Tsai, Hong-Chang Lee, Wenxue Wu, Xiaoyong Fu
  • Synthesis of himbacine analogs
    Patent number: 7541471
    Abstract: The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: June 2, 2009
    Assignee: Schering Corporation
    Inventors: Tiruvettipuram K Thiruvengadam, Tao Wang, Jing Liao, John S Chiu, David Jieh-Shyh Tsai, Hong-Chang Lee, Wenxue Wu, Xiaoyong Fu
  • Preparation of pharmaceutical salts
    Patent number: 7534884
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: May 19, 2009
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David J. S. Tsai, Wenxue Wu