Patents by Inventor Wenxue Wu

Wenxue Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Constrained himbacine analogs as thrombin receptor antagonists
    Publication number: 20050267155
    Abstract: A compound represented by the structural formula and pharmaceutically acceptable salts and solvents thereof is disclosed, wherein: the single-dashed line between the ring carbons to which R10 and R34 are attached represents either a single bond or a double bond; the double-dashed line between X and the carbon to which Y is attached represents either a single bond or an absent bond; X is —O— or —NR6— when the double-dashed line represents a single bond; X is H, —OH or —NHR20 when the double-dashed line represents an absent bond; and other parameters are as defined herein. Also disclosed are pharmaceutical compositions and combinations containing said compounds and their uses as thrombin receptor antagonists and binders to cannabinoid receptors.
    Type: Application
    Filed: May 25, 2005
    Publication date: December 1, 2005
    Inventors: Mariappan Chelliah, Samuel Chackalamannil, Yan Xia, Martin Clasby, William Greenlee, Yuguang Wang, Enrico Veltri, Wenxue Wu, Michael Graziano, Teddy Kosoglou, Madhu Chintala
  • Preparation of salts of 4-[4-[(1R)-[4-(trifluoromethyl)phenyl]-2-methoxyethyl]-(3S)-methyl-1-piperazinyl]-4-methyl-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]
    Patent number: 6943251
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: September 13, 2005
    Assignee: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David Js Tsai, Wenxue Wu
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Publication number: 20050171120
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Inventors: Wenxue Wu, Hongbiao Liao, David Tsai, David Andrews, Dinesh Gala, Gary Lee, Martin Schwartz, Timothy McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram Thiruvengadam, Chou-Hang Tann
  • Preparation of pharmaceutical salts
    Publication number: 20050171117
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 4, 2005
    Inventors: Dinesh Gala, Andrew Goodman, Gary Lee, Hongbiao Liao, Martin Schwartz, Suhan Tang, David Tsai, Wenxue Wu
  • Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors
    Publication number: 20050124655
    Abstract: In one embodiment, the present application discloses a process for making the compound of the formula:
    Type: Application
    Filed: September 13, 2004
    Publication date: June 9, 2005
    Inventors: David Andrews, Suhan Tang, Wenxue Wu, Sami Kalliney, Anantha Sudhakar, Christopher Nielsen
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Patent number: 6872826
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Methods of use of thrombin receptor antagonists
    Publication number: 20040192753
    Abstract: A method of treating a therapeutic condition comprising administering to a mammal in need of such treatment an effective amount of at least one compound of the formulas: 1
    Type: Application
    Filed: November 10, 2003
    Publication date: September 30, 2004
    Inventors: Samuel Chackalamannil, Yan Xia, Enrico P. Veltri, Mariappan V. Chelliah, Wenxue Wu, Michael P. Graziano, Teddy Kosoglou, Madhu Chintala
  • Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
    Publication number: 20040176418
    Abstract: A crystalline polymorph of a bislulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1, or which exhibits a differential scanning calorimtery profile substantially the same as that shown in FIG.
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Schering Corporation
    Inventors: Tiruvettipuram K. Thiruvengadam, Wenxue Wu, Tao Wang, John S. Chiu, Susan Bogdanowich-Knipp, Anastasia Pavlovsky, William J. Greenlee, Michael P. Graziano, Teddy Kosoglou, Madhu Chintala, Samuel Chackalamannil
  • Stereoselective alkylation of chiral 2-methyl-4-protected piperazines
    Publication number: 20030208074
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: November 6, 2003
    Applicant: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
    Patent number: 6642385
    Abstract: In one embodiment, the present invention describes the synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 4, 2003
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J Tsai
  • Preparation of pharmaceutical salts
    Publication number: 20030144510
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of rotamers of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 31, 2003
    Applicant: Schering Corporation
    Inventors: Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L. Schwartz, Suhan Tang, David Js Tsai, Wenxue Wu
  • Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
    Publication number: 20030105136
    Abstract: In one embodiment, the present invention describes the synthesis of 4-(piperidyl) (2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.
    Type: Application
    Filed: October 11, 2002
    Publication date: June 5, 2003
    Applicant: SCHERING CORPORATION
    Inventors: Wenxue Wu, Hongbiao Liao, David J.S. Tsai