Abstract: The present invention relates to a gonadotropin-releasing hormone antagonist, which has an antagonistic activity against gonadotropin-releasing hormone and can be used for the prevention or treatment of a sex hormone-dependent disease, such as benign prostatic hypertrophy, hysteromyoma, endometriosis, metrofibroma, precocious puberty, amenorrhea, premenstrual syndrome, or dysmenorrhea, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, and a pharmaceutical composition comprising the same.

Abstract: A heat treatment apparatus is provided, which includes: a first cover plate including three or more first windows; a second cover plate including two or more second windows, the second windows are transmissive to radiation with a wavelength of 2.7 ?m; a workpiece support element between the first cover plate and the second cover plate, configured to support the semiconductor workpiece; a temperature measurement component comprising an infrared emitter, at least two infrared reflection sensors that are successive and at least two infrared transmission sensors, where the three or more first windows comprise a first window at a first position, a first window at least one middle position and a first window at a final position in a horizontal direction away from the infrared emitter, and a surface facing to the second cover plate of the first window at the middle position has a reflection transmission coating layer.

Abstract: A heat treatment apparatus is provided, which includes: a reaction chamber defined by an upper cover plate, a lower cover plate and a reaction chamber body; an infrared emitter located at an end of the upper cover plate; an infrared reflection sensor located at another end of the upper cover plate, and an infrared transmission sensor located at another end of the lower cover plate. The infrared emitter and the infrared reflection sensor are located at a side of the upper cover plate facing to the reaction chamber, the infrared transmission sensor is located at a side of the lower cover plate facing to the reaction chamber, the infrared emitter is located on a sidewall of an end of the reaction chamber body, and the infrared reflection sensor and the infrared transmission sensor are located on a sidewall of another end of the reaction chamber body.

Abstract: The examples of the present disclosure provide a network management system, method, apparatus, and an electronic device. Wherein the network management system comprises a support unit, a data management unit, a business service unit and a display unit. The business service unit includes multiple groups of microservice subunits, each of the microservice subunits is used to provide a type of microservice, and the microservices provided by each group of the microservice subunits are jointly used to realize one management function. The support unit performs installation and deployment on all the microservice subunits through the same installation and deployment logic, and the support unit performs operation management on all the microservice subunits through the same operation management logic. The data management unit stores data of all the microservice subunits through the same data storage logic, and the data management unit encapsulates the access logic of each type of data into the same access logic.

Abstract: Disclosed is a high ultraviolet blocking polylactic acid composite material reinforced by POSS modified bamboo powder. The preparation method therefor includes steps of carrying out chemical grafting modification of bamboo powder with proper particle size by using POSS containing specific organic groups, and then adding the modified bamboo powder to polylactic acid for melting and co-extrusion to obtain POSS modified bamboo powder. The present disclosure makes full use of the 30% lignin in the bamboo powder, having the advantages of wide source, biological metabolizability and low price; the present disclosure does not need the traditional inorganic ultraviolet blocking agent, nor need to extract refined lignin from natural materials, but directly takes inexpensive and easy-to-obtain bamboo powder as main raw material. The composite material prepared in the present disclosure can greatly improve the UV blocking performance, mechanical properties and thermal stability of the PLA.

Abstract: Disclosed is a high ultraviolet blocking polylactic acid composite material reinforced by POSS modified bamboo powder. The preparation method therefor includes steps of carrying out chemical grafting modification of bamboo powder with proper particle size by using POSS containing specific organic groups, and then adding the modified bamboo powder to polylactic acid for melting and co-extrusion to obtain POSS modified bamboo powder. The present disclosure makes full use of the 30% lignin in the bamboo powder, having the advantages of wide source, biological metabolizability and low price; the present disclosure does not need the traditional inorganic ultraviolet blocking agent, nor need to extract refined lignin from natural materials, but directly takes inexpensive and easy-to-obtain bamboo powder as main raw material. The composite material prepared in the present disclosure can greatly improve the UV blocking performance, mechanical properties and thermal stability of the PLA.

Abstract: This application relates to preparation of organic photomultiplication photodetectors, and more particularly to an organic photomultiplication photodetector with bi-directional bias response and a method for producing the same. The photodetector includes an anode layer, an anode modification layer, an interfacial modification layer, an active layer and a cathode layer arranged in sequence. The interfacial modification layer is made of Al2O3. The anode layer is made of indium tin oxide (ITO). The anode modification layer is made of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS). The active layer is made of poly(3-hexylthiophene-2,5-diyl):[6,6]-phenyl-C70-butyric acid methyl ester (P3HT:PC70BM). The cathode layer is made of aluminum, silver or gold.

Abstract: A method and a system of generating a smooth spline surface from a quadrilateral mesh representing a physical object, is described. Edge points are added to the quadrilateral mesh to preserve a feature or a boundary. The edge points are added to an edge of the quadrilateral mesh having one or more irregular nodes representing a feature edge of the physical object and/or the edge points are added to an edge of the quadrilateral mesh extending between the feature edge and an irregular node. Knot interval vectors are extracted for each edge point and used to evaluate an irregular element having the edge points to generate the smooth spline surface. The smooth spline surface is highly continuous and can be displayed to model the physical object, modify a design of the physical object, or used directly in a simulation to evaluate the physical object. Other embodiments are also described and claimed.

Abstract: The present invention relates to a novel compound as a 5-HT2A receptor inhibitor or inverse agonist, a preparation method therefor, and a pharmaceutical composition thereof. The present invention also relates to an application of the compound or the pharmaceutical composition in the preparation of a drug for treating 5-HT2A receptor-related diseases, the diseases comprising: non-motor symptoms caused by Parkinson's disease: delusion, illusion, depression, anxiety, cognitive disorder, and sleep disorder; dementia-related mental diseases; major depressive disorder; or negative symptoms of schizophrenia, etc.

Abstract: Computer-implemented systems and methods for generating a mesh and conformally connecting the mesh to an existing mesh are provided. The existing mesh is displayed via a graphical user interface (GUI) of a computer-aided design modeling system using a processing system. A polyhedral mesh is generated in an empty space adjacent to the existing mesh using the processing system. The generating of the polyhedral mesh includes (i) defining the empty space as a first surface mesh comprising triangles, quadrilaterals, polygonals, or a mixture thereof, (ii) generating a dual of the first surface mesh to form a second surface mesh, the empty space being enclosed by the second surface mesh, and (iii) filling a gap region between the first and second surface meshes with the polyhedral mesh and conformally connecting the polyhedral mesh to the existing mesh using the processing system.

Abstract: This application relates to preparation of organic photomultiplication photodetectors, and more particularly to an organic photomultiplication photodetector with bi-directional bias response and a method for producing the same. The photodetector includes an anode layer, an anode modification layer, an interfacial modification layer, an active layer and a cathode layer arranged in sequence. The interfacial modification layer is made of Al2O3. The anode layer is made of indium tin oxide (ITO). The anode modification layer is made of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOTP SS). The active layer is made of poly(3-hexylthiophene-2,5-diyl):[6,6]-phenyl-C70-butyric acid methyl ester (P3HT:PC70BM). The cathode layer is made of aluminum, silver or gold.

Abstract: Computer-implemented systems and methods for generating a mesh and conformally connecting the mesh to an existing mesh are provided. The existing mesh is displayed via a graphical user interface (GUI) of a computer-aided design modeling system using a processing system. A polyhedral mesh is generated in an empty space adjacent to the existing mesh using the processing system. The generating of the polyhedral mesh includes (i) defining the empty space as a first surface mesh comprising triangles, quadrilaterals, polygonals, or a mixture thereof, (ii) generating a dual of the first surface mesh to form a second surface mesh, the empty space being enclosed by the second surface mesh, and (iii) filling a gap region between the first and second surface meshes with the polyhedral mesh and conformally connecting the polyhedral mesh to the existing mesh using the processing system.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Abstract: A method and apparatus for disabling an alarm in a device, and a storage medium are provided. The method includes: when a powering-off event for the device is detected, determining whether a condition for disabling a preset alarm in the device is satisfied; and when the condition for disabling the preset alarm in the device is satisfied, disabling the preset alarm in the device to prevent the preset alarm from being activated when the device is in a powered-off state.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.

Abstract: A method and apparatus for disabling an alarm in a device, and a storage medium are provided. The method includes: when a powering-off event for the device is detected, determining whether a condition for disabling a preset alarm in the device is satisfied; and when the condition for disabling the preset alarm in the device is satisfied, disabling the preset alarm in the device to prevent the preset alarm from being activated when the device is in a powered-off state.

Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.